PMID- 29734675
OWN - NLM
STAT- MEDLINE
DCOM- 20181115
LR  - 20240318
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 10
IP  - 5
DP  - 2018 May 4
TI  - Selected Physiological Effects of a Garcinia Gummi-Gutta Extract in Rats Fed with 
      Different Hypercaloric Diets.
LID - 10.3390/nu10050565 [doi]
LID - 565
AB  - Garcinia gummi-gutta (GGG) rind extract is effective for reducing appetite, body 
      weight and adiposity of obese rodents fed high-fat (HF), high-sugar (HS) or high 
      fat/sugar (HFS)-based diets, but these effects have not been simultaneously 
      evaluated. Thirty obese (~425 g) male Wistar rats were fed for eleven weeks with 
      six hypercaloric diets (4.1 kcal/g; five rats/diet) non-supplemented (HF, HS, 
      HFS), or supplemented (HF+, HS+, HFS+) with GGG extract (5.9%), while rats from 
      the control group (375 g) were fed a normocaloric diet (3.5 kcal/g). Body weight, 
      dietary intake, body fat distribution, and histological and biochemical 
      parameters were recorded. Compared to control rats, non-supplemented and 
      supplemented groups consumed significantly less food (14.3% and 24.6% (−4.3 
      g/day), respectively) (p < 0.05). Weight loss was greater in the HF+ group (35(-)52 
      g), which consumed 1.9 times less food than the HS+ or HFS+ fed groups. The HF 
      and HFS groups showed 40% less plasma triacylglycerides and lower glucose levels 
      compared to the HF+. GGG-supplemented diets were associated with lower ketonuria. 
      The HF+ diet was associated with the best anti-adiposity effect (as measured with 
      the dual X-ray absorptiometry (DXA) and Soxhlet methods). The severity of 
      hepatocyte lipidosis was HF > control > HF+, and no signs of toxicity in the 
      testes were observed. The results indicate that GGG is more effective when 
      co-administered with HF diets in obese rats.
FAU - Guillen-Enriquez, Carolina
AU  - Guillen-Enriquez C
AD  - Instituto de Ciencias Biomedicas, Universidad Autonoma de Ciudad Juarez, Anillo 
      Envolvente del PRONAF y Estocolmo s/n, Ciudad Juarez 32310, Chihuahua, Mexico. 
      carolina.guillen@uacj.mx.
FAU - Lopez-Teros, Veronica
AU  - Lopez-Teros V
AUID- ORCID: 0000-0003-1429-4911
AD  - Division de Ciencias Biologicas y de la Salud, Universidad de Sonora, Hermosillo 
      83000, Sonora, Mexico. veronica.lopez@unison.mx.
FAU - Martin-Orozco, Ubicelio
AU  - Martin-Orozco U
AD  - Instituto de Ciencias Biomedicas, Universidad Autonoma de Ciudad Juarez, Anillo 
      Envolvente del PRONAF y Estocolmo s/n, Ciudad Juarez 32310, Chihuahua, Mexico. 
      umartin@uacj.mx.
FAU - Lopez-Diaz, Jose A
AU  - Lopez-Diaz JA
AUID- ORCID: 0000-0002-4059-665X
AD  - Instituto de Ciencias Biomedicas, Universidad Autonoma de Ciudad Juarez, Anillo 
      Envolvente del PRONAF y Estocolmo s/n, Ciudad Juarez 32310, Chihuahua, Mexico. 
      joslopez@uacj.mx.
FAU - Del Hierro-Ochoa, Julio
AU  - Del Hierro-Ochoa J
AD  - Instituto de Ciencias Biomedicas, Universidad Autonoma de Ciudad Juarez, Anillo 
      Envolvente del PRONAF y Estocolmo s/n, Ciudad Juarez 32310, Chihuahua, Mexico. 
      jdelhier@uacj.mx.
FAU - Ramos-Jimenez, Arnulfo
AU  - Ramos-Jimenez A
AUID- ORCID: 0000-0002-4347-6725
AD  - Instituto de Ciencias Biomedicas, Universidad Autonoma de Ciudad Juarez, Anillo 
      Envolvente del PRONAF y Estocolmo s/n, Ciudad Juarez 32310, Chihuahua, Mexico. 
      aramos@uacj.mx.
FAU - Astiazaran-Garcia, Humberto
AU  - Astiazaran-Garcia H
AUID- ORCID: 0000-0002-2452-0057
AD  - Centro de Investigacion en Alimentacion y Desarrollo, AC (Unidad Hermosillo), 
      Coordinacion de Nutricion, Carretera a la Victoria km. 0.6, AP 1735, Hermosillo 
      83000, Sonora, Mexico. hastiazaran@ciad.mx.
FAU - Martinez-Ruiz, Nina Del Rocio
AU  - Martinez-Ruiz NDR
AUID- ORCID: 0000-0002-6447-9861
AD  - Instituto de Ciencias Biomedicas, Universidad Autonoma de Ciudad Juarez, Anillo 
      Envolvente del PRONAF y Estocolmo s/n, Ciudad Juarez 32310, Chihuahua, Mexico. 
      nmartine@uacj.mx.
FAU - Wall-Medrano, Abraham
AU  - Wall-Medrano A
AUID- ORCID: 0000-0002-6196-3607
AD  - Instituto de Ciencias Biomedicas, Universidad Autonoma de Ciudad Juarez, Anillo 
      Envolvente del PRONAF y Estocolmo s/n, Ciudad Juarez 32310, Chihuahua, Mexico. 
      awall@uacj.mx.
LA  - eng
PT  - Journal Article
DEP - 20180504
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Sugars)
RN  - 0 (Ketones)
RN  - 0 (Plant Extracts)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Absorptiometry, Photon
MH  - Adiposity/drug effects
MH  - Animals
MH  - Biological Assay
MH  - Blood Glucose/metabolism
MH  - Body Fat Distribution
MH  - Body Weight
MH  - Cholesterol/blood
MH  - *Diet, High-Fat
MH  - Dietary Sugars/*administration & dosage
MH  - Dietary Supplements
MH  - Garcinia/*chemistry
MH  - Ketones/blood
MH  - Ketosis/blood/drug therapy
MH  - Male
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Triglycerides/blood
PMC - PMC5986445
OTO - NOTNLM
OT  - DXA
OT  - Garcinia cambogia
OT  - Western diet
OT  - high-fat diets
OT  - hydroxicitric acid
OT  - obesity
COIS- The authors declare no conflict of interest.
EDAT- 2018/05/08 06:00
MHDA- 2018/11/16 06:00
PMCR- 2018/05/01
CRDT- 2018/05/09 06:00
PHST- 2018/03/01 00:00 [received]
PHST- 2018/04/18 00:00 [revised]
PHST- 2018/05/02 00:00 [accepted]
PHST- 2018/05/09 06:00 [entrez]
PHST- 2018/05/08 06:00 [pubmed]
PHST- 2018/11/16 06:00 [medline]
PHST- 2018/05/01 00:00 [pmc-release]
AID - nu10050565 [pii]
AID - nutrients-10-00565 [pii]
AID - 10.3390/nu10050565 [doi]
PST - epublish
SO  - Nutrients. 2018 May 4;10(5):565. doi: 10.3390/nu10050565.