PMID- 29735355
OWN - NLM
STAT- MEDLINE
DCOM- 20190808
LR  - 20220409
IS  - 1878-4046 (Electronic)
IS  - 1076-6332 (Linking)
VI  - 25
IP  - 9
DP  - 2018 Sep
TI  - Association of Focal Radiation Dose Adjusted on Cross Sections with Subsolid 
      Nodule Visibility and Quantification on Computed Tomography Images Using AIDR 3D: 
      Comparison Among Scanning at 84, 42, and 7 mAs.
PG  - 1156-1166
LID - S1076-6332(18)30053-9 [pii]
LID - 10.1016/j.acra.2018.01.024 [doi]
AB  - RATIONALE AND OBJECTIVES: The objectives of this study were to compare the 
      visibility and quantification of subsolid nodules (SSNs) on computed tomography 
      (CT) using adaptive iterative dose reduction using three-dimensional processing 
      between 7 and 42 mAs and to assess the association of size-specific dose estimate 
      (SSDE) with relative measured value change between 7 and 84 mAs (RMVC(7-84)) and 
      relative measured value change between 42 and 84 mAs (RMVC(42-84)). MATERIALS AND 
      METHODS: As a Japanese multicenter research project (Area-detector Computed 
      Tomography for the Investigation of Thoracic Diseases [ACTIve] study), 50 
      subjects underwent chest CT with 120 kV, 0.35 second per location and three tube 
      currents: 240 mA (84 mAs), 120 mA (42 mAs), and 20 mA (7 mAs). Axial CT images 
      were reconstructed using adaptive iterative dose reduction using 
      three-dimensional processing. SSN visibility was assessed with three grades (1, 
      obscure, to 3, definitely visible) using CT at 84 mAs as reference standard and 
      compared between 7 and 42 mAs using t test. Dimension, mean CT density, and 
      particular SSDE to the nodular center of 71 SSNs and volume of 58 SSNs (diameter 
      >5 mm) were measured. Measured values (MVs) were compared using Wilcoxon 
      signed-rank tests among CTs at three doses. Pearson correlation analyses were 
      performed to assess the association of SSDE with RMVC(7-84): 100 x (MV at 
      7 mAs - MV at 84 mAs)/MV at 84 mAs and RMVC(42-84). RESULTS: SSN visibilities 
      were similar between 7 and 42 mAs (2.76 +/- 0.45 vs 2.78 +/- 0.40) (P = .67). For 
      larger SSNs (>8 mm), MVs were similar among CTs at three doses (P > .05). For 
      smaller SSNs (<8 mm), dimensions and volumes on CT at 7 mAs were larger and the 
      mean CT density was smaller than 42 and 84 mAs, and SSDE had mild negative 
      correlations with RMVC(7-84) (P < .05). CONCLUSIONS: Comparable quantification 
      was demonstrated irrespective of doses for larger SSNs. For smaller SSNs, nodular 
      exaggerating effect associated with decreased SSDE on CT at 7 mAs compared to 
      84 mAs could result in comparable visibilities to CT at 42 mAs.
CI  - Copyright (c) 2018 The Association of University Radiologists. Published by 
      Elsevier Inc. All rights reserved.
FAU - Nagatani, Yukihiro
AU  - Nagatani Y
AD  - Department of Radiology, Shiga University of Medical Science, Seta-tsukinowa-cho, 
      Otsu, Shiga, 520-2192, Japan. Electronic address: yatsushi@belle.shiga-med.ac.jp.
FAU - Moriya, Hiroshi
AU  - Moriya H
AD  - Department of Radiology, Ohara General Hospital, Fukushima, Fukushima, Japan.
FAU - Noma, Satoshi
AU  - Noma S
AD  - Department of Radiology, Tenri Hospital, Tenri, Nara, Japan.
FAU - Sato, Shigetaka
AU  - Sato S
AD  - Department of Radiology, Shiga University of Medical Science, Seta-tsukinowa-cho, 
      Otsu, Shiga, 520-2192, Japan.
FAU - Tsukagoshi, Shinsuke
AU  - Tsukagoshi S
AD  - CT System Division, Toshiba Medical Systems, Otawara, Tochigi, Japan.
FAU - Yamashiro, Tsuneo
AU  - Yamashiro T
AD  - Department of Radiology, Graduate School of Medical Science, University of the 
      Ryukyus, Nishihara, Okinawa, Japan.
FAU - Koyama, Mitsuhiro
AU  - Koyama M
AD  - Department of Radiology, Osaka Medical College, Takatsuki, Osaka, Japan.
FAU - Tomiyama, Noriyuki
AU  - Tomiyama N
AD  - Department of Radiology, Osaka University Graduate School of Medicine, Suita, 
      Osaka, Japan.
FAU - Ono, Yoshiharu
AU  - Ono Y
AD  - Department of Radiology, Kobe University Graduate School of Medicine, Kobe, 
      Hyogo, Japan.
FAU - Murayama, Sadayuki
AU  - Murayama S
AD  - Department of Radiology, Graduate School of Medical Science, University of the 
      Ryukyus, Nishihara, Okinawa, Japan.
FAU - Murata, Kiyoshi
AU  - Murata K
AD  - Department of Radiology, Shiga University of Medical Science, Seta-tsukinowa-cho, 
      Otsu, Shiga, 520-2192, Japan.
CN  - Investigators of ACTIve Study Group
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20180504
PL  - United States
TA  - Acad Radiol
JT  - Academic radiology
JID - 9440159
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - *Imaging, Three-Dimensional
MH  - Male
MH  - Middle Aged
MH  - *Radiation Dosage
MH  - Radiographic Image Interpretation, Computer-Assisted/methods
MH  - Solitary Pulmonary Nodule/*diagnostic imaging
MH  - Tomography, X-Ray Computed/*methods
OTO - NOTNLM
OT  - Computed tomography
OT  - iterative reconstruction
OT  - reduced radiation dose
OT  - size-specific dose estimate
OT  - subsolid nodule quantification
FIR - Koyama, Mitsuhiro
IR  - Koyama M
IRAD- Osaka Medical College, Takatsuki, Osaka, Japan.
FIR - Narumi, Yoshifumi
IR  - Narumi Y
IRAD- Osaka Medical College, Takatsuki, Osaka, Japan.
FIR - Yanagawa, Masahiro
IR  - Yanagawa M
IRAD- Osaka University, Suita, Osaka, Japan.
FIR - Honda, Osamu
IR  - Honda O
IRAD- Osaka University, Suita, Osaka, Japan.
FIR - Tomiyama, Noriyuki
IR  - Tomiyama N
IRAD- Osaka University, Suita, Osaka, Japan.
FIR - Ohno, Yoshiharu
IR  - Ohno Y
IRAD- Kobe University, Kobe, Hyogo, Japan.
FIR - Sugimura, Kazuro
IR  - Sugimura K
IRAD- Kobe University, Kobe, Hyogo, Japan.
FIR - Sakuma, Kotaro
IR  - Sakuma K
IRAD- Ohara General Hospital, Fukushima, Fukushima, Japan.
FIR - Moriya, Hiroshi
IR  - Moriya H
IRAD- Ohara General Hospital, Fukushima, Fukushima, Japan.
FIR - Tada, Akihiro
IR  - Tada A
IRAD- Okayama University, Okayama, Okayama, Japan.
FIR - Kanazawa, Susumu
IR  - Kanazawa S
IRAD- Okayama University, Okayama, Okayama, Japan.
FIR - Sakai, Fumikazu
IR  - Sakai F
IRAD- Saitama Medical University International Medical Center, Hidaka, Saitama, Japan.
FIR - Nishimoto, Yuko
IR  - Nishimoto Y
IRAD- Tenri Hospital, Tenri, Nara, Japan.
FIR - Noma, Satoshi
IR  - Noma S
IRAD- Tenri Hospital, Tenri, Nara, Japan.
FIR - Tsuchiya, Nanae
IR  - Tsuchiya N
IRAD- University of the Ryukyus, Nishihara, Okinawa, Japan.
FIR - Tsubakimoto, Maho
IR  - Tsubakimoto M
IRAD- University of the Ryukyus, Nishihara, Okinawa, Japan.
FIR - Yamashiro, Tsuneo
IR  - Yamashiro T
IRAD- University of the Ryukyus, Nishihara, Okinawa, Japan.
FIR - Murayama, Sadayuki
IR  - Murayama S
IRAD- University of the Ryukyus, Nishihara, Okinawa, Japan.
FIR - Sato, Shigetaka
IR  - Sato S
IRAD- Shiga University of Medical Science, Otsu, Shiga, Japan.
FIR - Nagatani, Yukihiro
IR  - Nagatani Y
IRAD- Shiga University of Medical Science, Otsu, Shiga, Japan.
FIR - Nitta, Norihisa
IR  - Nitta N
IRAD- Shiga University of Medical Science, Otsu, Shiga, Japan.
FIR - Murata, Kiyoshi
IR  - Murata K
IRAD- Shiga University of Medical Science, Otsu, Shiga, Japan.
EDAT- 2018/05/08 06:00
MHDA- 2019/08/09 06:00
CRDT- 2018/05/09 06:00
PHST- 2017/12/28 00:00 [received]
PHST- 2018/01/17 00:00 [revised]
PHST- 2018/01/18 00:00 [accepted]
PHST- 2018/05/08 06:00 [pubmed]
PHST- 2019/08/09 06:00 [medline]
PHST- 2018/05/09 06:00 [entrez]
AID - S1076-6332(18)30053-9 [pii]
AID - 10.1016/j.acra.2018.01.024 [doi]
PST - ppublish
SO  - Acad Radiol. 2018 Sep;25(9):1156-1166. doi: 10.1016/j.acra.2018.01.024. Epub 2018 
      May 4.