PMID- 29735362 OWN - NLM STAT- MEDLINE DCOM- 20191023 LR - 20240330 IS - 1879-1484 (Electronic) IS - 0021-9150 (Print) IS - 0021-9150 (Linking) VI - 275 DP - 2018 Aug TI - MRI with gadofosveset: A potential marker for permeability in myocardial infarction. PG - 400-408 LID - S0021-9150(18)30209-0 [pii] LID - 10.1016/j.atherosclerosis.2018.04.024 [doi] AB - BACKGROUND AND AIMS: Acute ischemia is associated with myocardial endothelial damage and microvessel formation, resulting in leakage of plasma albumin into the myocardial extravascular space. In this study, we tested whether an albumin-binding intravascular contrast agent (gadofosveset) allows for improved quantification of myocardial permeability compared to the conventional extracellular contrast agent Gd-DTPA using late gadolinium enhancement (LGE) and T1 mapping in vivo. METHODS: MI was induced in C57BL/6 mice (n = 6) and cardiac magnetic resonance imaging (CMR) was performed at 3, 10 and 21 days post-MI using Gd-DTPA and 24 h later using gadofosveset. Functional, LGE and T1 mapping protocols were performed 45 min post-injection of the contrast agent. RESULTS: LGE images showed that both contrast agents provided similar measurements of infarct area at all time points following MI. Importantly, the myocardial R(1) measurements after administration of gadofosveset were higher in the acute phase-day 3 (R1 [s(-1)] = 6.29 +/- 0.29) compared to the maturation phase-days 10 and 21 (R1 [s(-1)] = 4.76 +/- 0.30 and 4.48 +/- 0.14), suggesting that the uptake of this agent could be used to stage myocardial remodeling. No differences in myocardial R1 were observed after administration of Gd-DTPA at different time points post-MI (R1 [s(-1)] = 3d: 3.77 +/- 0.37; 10d: 2.74 +/- 0.06; 21d: 3.35 +/- 0.26). The MRI results were validated by ex vivo histology that showed albumin leakage in the myocardium in the acute phase and microvessel formation at later stages. CONCLUSIONS: We demonstrate the merits of an albumin-binding contrast agent for monitoring changes in myocardial permeability between acute ischemia and chronic post-MI myocardial remodeling. CI - Copyright (c) 2018 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Lavin, Begona AU - Lavin B AD - School of Biomedical Engineering Imaging Sciences, King's College London, London, UK; The British Heart Foundation Centre of Excellence, Cardiovascular Division, King's College London, London, United Kingdom. Electronic address: begona.lavin_plaza@kcl.ac.uk. FAU - Protti, Andrea AU - Protti A AD - School of Biomedical Engineering Imaging Sciences, King's College London, London, UK; The British Heart Foundation Centre of Excellence, Cardiovascular Division, King's College London, London, United Kingdom; Cardiovascular Division, James Black Centre, King's College Hospital Denmark Hill London, London, SE5 9NU, United Kingdom. FAU - Lorrio, Silvia AU - Lorrio S AD - School of Biomedical Engineering Imaging Sciences, King's College London, London, UK; The British Heart Foundation Centre of Excellence, Cardiovascular Division, King's College London, London, United Kingdom. FAU - Dong, Xuebin AU - Dong X AD - Cardiovascular Division, James Black Centre, King's College Hospital Denmark Hill London, London, SE5 9NU, United Kingdom. FAU - Phinikaridou, Alkystis AU - Phinikaridou A AD - School of Biomedical Engineering Imaging Sciences, King's College London, London, UK; The British Heart Foundation Centre of Excellence, Cardiovascular Division, King's College London, London, United Kingdom. FAU - Botnar, Rene M AU - Botnar RM AD - School of Biomedical Engineering Imaging Sciences, King's College London, London, UK; The British Heart Foundation Centre of Excellence, Cardiovascular Division, King's College London, London, United Kingdom; Pontificia Universidad Catolica de Chile, Escuela de Ingenieria, Santiago, Chile. FAU - Shah, Ajay AU - Shah A AD - The British Heart Foundation Centre of Excellence, Cardiovascular Division, King's College London, London, United Kingdom; Cardiovascular Division, James Black Centre, King's College Hospital Denmark Hill London, London, SE5 9NU, United Kingdom. LA - eng GR - RG/12/1/29262/BHF_/British Heart Foundation/United Kingdom GR - RG/13/11/30384/BHF_/British Heart Foundation/United Kingdom GR - 203148/Z/16/Z/Wellcome Trust/United Kingdom GR - Department of Health/United Kingdom PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180425 PL - Ireland TA - Atherosclerosis JT - Atherosclerosis JID - 0242543 RN - 0 (Contrast Media) RN - 0 (Organometallic Compounds) RN - AU0V1LM3JT (Gadolinium) RN - K2I13DR72L (Gadolinium DTPA) RN - XM33Q67UVH (gadofosveset trisodium) SB - IM MH - Animals MH - *Capillary Permeability MH - Contrast Media/*administration & dosage/pharmacokinetics MH - Coronary Vessels/*metabolism/physiopathology MH - Disease Models, Animal MH - Female MH - Gadolinium/*administration & dosage/pharmacokinetics MH - Gadolinium DTPA/*administration & dosage/pharmacokinetics MH - Magnetic Resonance Imaging, Cine/*methods MH - Mice, Inbred C57BL MH - Myocardial Infarction/*diagnostic imaging/metabolism/pathology/physiopathology MH - Myocardium/pathology MH - Organometallic Compounds/*administration & dosage/pharmacokinetics MH - Predictive Value of Tests MH - Time Factors MH - Ventricular Function, Left MH - Ventricular Remodeling PMC - PMC6100880 OTO - NOTNLM OT - Albumin OT - Magnetic resonance imaging OT - Myocardial infarction OT - Permeability OT - Remodeling EDAT- 2018/05/08 06:00 MHDA- 2019/10/24 06:00 PMCR- 2018/08/01 CRDT- 2018/05/09 06:00 PHST- 2017/12/23 00:00 [received] PHST- 2018/03/27 00:00 [revised] PHST- 2018/04/18 00:00 [accepted] PHST- 2018/05/08 06:00 [pubmed] PHST- 2019/10/24 06:00 [medline] PHST- 2018/05/09 06:00 [entrez] PHST- 2018/08/01 00:00 [pmc-release] AID - S0021-9150(18)30209-0 [pii] AID - 10.1016/j.atherosclerosis.2018.04.024 [doi] PST - ppublish SO - Atherosclerosis. 2018 Aug;275:400-408. doi: 10.1016/j.atherosclerosis.2018.04.024. Epub 2018 Apr 25.