PMID- 29735552
OWN - NLM
STAT- MEDLINE
DCOM- 20190829
LR  - 20240416
IS  - 1538-7445 (Electronic)
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 78
IP  - 14
DP  - 2018 Jul 15
TI  - HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of 
      Non-Hodgkin Lymphoma Subtypes.
PG  - 4086-4096
LID - 10.1158/0008-5472.CAN-17-2900 [doi]
AB  - A growing number of loci within the human leukocyte antigen (HLA) region have 
      been implicated in non-Hodgkin lymphoma (NHL) etiology. Here, we test a 
      complementary hypothesis of "heterozygote advantage" regarding the role of HLA 
      and NHL, whereby HLA diversity is beneficial and homozygous HLA loci are 
      associated with increased disease risk. HLA alleles at class I and II loci were 
      imputed from genome-wide association studies (GWAS) using SNP2HLA for 3,617 
      diffuse large B-cell lymphomas (DLBCL), 2,686 follicular lymphomas (FL), 2,878 
      chronic lymphocytic leukemia/small lymphocytic lymphomas (CLL/SLL), 741 marginal 
      zone lymphomas (MZL), and 8,753 controls of European descent. Both DLBCL and MZL 
      risk were elevated with homozygosity at class I HLA-B and -C loci (OR DLBCL = 
      1.31, 95% CI = 1.06-1.60; OR MZL = 1.45, 95% CI = 1.12-1.89) and class II 
      HLA-DRB1 locus (OR DLBCL = 2.10, 95% CI = 1.24-3.55; OR MZL = 2.10, 95% CI = 
      0.99-4.45). Increased FL risk was observed with the overall increase in number of 
      homozygous HLA class II loci (P trend < 0.0001, FDR = 0.0005). These results 
      support a role for HLA zygosity in NHL etiology and suggests that distinct immune 
      pathways may underly the etiology of the different NHL subtypes.Significance: HLA 
      gene diversity reduces risk for non-Hodgkin lymphoma. Cancer Res; 78(14); 
      4086-96. (c)2018 AACR.
CI  - (c)2018 American Association for Cancer Research.
FAU - Wang, Sophia S
AU  - Wang SS
AD  - Department of Population Sciences, Beckman Research Institute and the City of 
      Hope, Duarte, California. sowang@coh.org.
FAU - Carrington, Mary
AU  - Carrington M
AD  - Cancer and Inflammation Program, Leidos Biomedical Research Inc., Frederick 
      National Laboratory for Cancer Research, Frederick, Maryland, and Ragon Institute 
      of MGH, MIT, and Harvard, Cambridge, Massachusetts.
FAU - Berndt, Sonja I
AU  - Berndt SI
AD  - Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
FAU - Slager, Susan L
AU  - Slager SL
AD  - Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
FAU - Bracci, Paige M
AU  - Bracci PM
AD  - Department of Epidemiology and Biostatistics, University of California-San 
      Francisco, San Francisco, California.
FAU - Voutsinas, Jenna
AU  - Voutsinas J
AD  - Department of Population Sciences, Beckman Research Institute and the City of 
      Hope, Duarte, California.
FAU - Cerhan, James R
AU  - Cerhan JR
AD  - Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
FAU - Smedby, Karin E
AU  - Smedby KE
AD  - Department of Medicine Solna, unit of clinical epidemiology, Karolinska 
      Institutet, Stockholm, Sweden.
AD  - Hematology Center, Karolinska University Hospital, Stockholm, Sweden.
FAU - Hjalgrim, Henrik
AU  - Hjalgrim H
AD  - Department of Epidemiology Research, Division of Health Surveillance and 
      Research, Statens Serum Institut, Copenhagen, Denmark.
AD  - Department of Hematology, Rishospitalet, Copenhagen, Denmark.
FAU - Vijai, Joseph
AU  - Vijai J
AD  - Department of Medicine, Memorial Sloan Kettering Cancer Center, New York City, 
      New York.
FAU - Morton, Lindsay M
AU  - Morton LM
AD  - Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
FAU - Vermeulen, Roel
AU  - Vermeulen R
AD  - Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the 
      Netherlands.
AD  - Julius Center for Health Sciences and Primary Care, University Medical Center 
      Utrecht, Utrecht, the Netherlands.
FAU - Paltiel, Ora
AU  - Paltiel O
AD  - Braun School of Public Health and Community Medicine, Hadassah-Hebrew University 
      Medical Center, Jerusalem, Israel.
FAU - Vajdic, Claire M
AU  - Vajdic CM
AD  - Centre for Big Data Research in Health, The University of New South Wales, 
      Sydney, New South Wales, Australia.
FAU - Linet, Martha S
AU  - Linet MS
AD  - Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
FAU - Nieters, Alexandra
AU  - Nieters A
AD  - Centre for Chronic Immunodeficiency, University Medical Center Freiburg, 
      Freiburg, Baden-Wurttemberg, Germany.
FAU - de Sanjose, Silvia
AU  - de Sanjose S
AD  - Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Institut 
      Catala d' Oncologia, IDIBELL, 08908 L'Hospitalet de Llobregat, Barcelona, Spain.
AD  - CIBER Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain.
FAU - Cozen, Wendy
AU  - Cozen W
AD  - Norris Comprehensive Cancer Center, Keck School of Medicine of USC, Departments 
      of Preventive Medicine and Pathology, University of Southern California, Los 
      Angeles, Calfornia.
FAU - Brown, Elizabeth E
AU  - Brown EE
AD  - Department of Pathology, School of Medicine and the UAB Comprehensive Cancer 
      Center, The University of Alabama at Birmingham, Birmingham, Alabama.
FAU - Turner, Jennifer
AU  - Turner J
AUID- ORCID: 0000-0001-5550-3375
AD  - Department of Histopathology, Douglass Hanly Moir Pathology, Sydney, Australia.
AD  - Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.
FAU - Spinelli, John J
AU  - Spinelli JJ
AD  - Cancer Control Research, British Columbia Cancer Agency, Vancouver, British 
      Columbia, Canada.
AD  - School of Population and Public Health, University of British Columbia, 
      Vancouver, British Columbia, Canada.
FAU - Zheng, Tongzhang
AU  - Zheng T
AD  - Department of Epidemiology, School of Public Health, Brown University, 
      Providence, Rhode Island.
FAU - Birmann, Brenda M
AU  - Birmann BM
AD  - Channing Division of Network Medicine, Department of Medicine, Brigham and 
      Women's Hospital and Harvard Medical School, Boston, Massachusetts.
FAU - Flowers, Christopher R
AU  - Flowers CR
AD  - Department of Hematology and Medical Oncology, Emory University School of 
      Medicine, Atlanta, Georgia.
FAU - Becker, Nikolaus
AU  - Becker N
AD  - Division of Clinical Epidemiology, German Cancer Research Centre, Heidelberg, 
      Baden-Wurttemberg, Germany.
FAU - Holly, Elizabeth A
AU  - Holly EA
AD  - Department of Epidemiology and Biostatistics, University of California-San 
      Francisco, San Francisco, California.
FAU - Kane, Eleanor
AU  - Kane E
AD  - Department of Health Sciences, University of York, York, United Kingdom.
FAU - Weisenburger, Dennis
AU  - Weisenburger D
AD  - Department of Pathology, City of Hope, Duarte, California.
FAU - Maynadie, Marc
AU  - Maynadie M
AD  - Registry of Hematological Malignancies of Cote d'Or, INSERM UMR1231, University 
      of Burgundy and Dijon University Hospital, Dijon, France.
FAU - Cocco, Pierluigi
AU  - Cocco P
AD  - Department of Public Health, Clinical and Molecular Medicine, University of 
      Cagliari, Cagliari, Italy.
FAU - Albanes, Demetrius
AU  - Albanes D
AD  - Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
FAU - Weinstein, Stephanie J
AU  - Weinstein SJ
AUID- ORCID: 0000-0002-3834-1535
AD  - Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
FAU - Teras, Lauren R
AU  - Teras LR
AD  - Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.
FAU - Diver, W Ryan
AU  - Diver WR
AD  - Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.
FAU - Lax, Stephanie J
AU  - Lax SJ
AD  - Department of Health Sciences, University of York, York, United Kingdom.
FAU - Travis, Ruth C
AU  - Travis RC
AD  - Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.
FAU - Kaaks, Rudolph
AU  - Kaaks R
AD  - Division of Clinical Epidemiology, German Cancer Research Centre, Heidelberg, 
      Baden-Wurttemberg, Germany.
FAU - Riboli, Elio
AU  - Riboli E
AD  - School of Public Health, Imperial College London, London, United Kingdom.
FAU - Benavente, Yolanda
AU  - Benavente Y
AD  - Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Institut 
      Catala d' Oncologia, IDIBELL, 08908 L'Hospitalet de Llobregat, Barcelona, Spain.
AD  - CIBER Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain.
FAU - Brennan, Paul
AU  - Brennan P
AD  - International Agency for Research on Cancer, Lyon, France.
FAU - McKay, James
AU  - McKay J
AD  - Department of Immunology, CHU Henri Mondor, Creteil, France.
FAU - Delfau-Larue, Marie-Helene
AU  - Delfau-Larue MH
AD  - Department of Immunology, CHU Henri Mondor, Creteil, France.
AD  - INSERM U 955, CHU Henri Mondor, Creteil, France.
FAU - Link, Brian K
AU  - Link BK
AD  - Department of Internal Medicine, Carver College of Medicine, The University of 
      Iowa, Iowa City, Iowa.
FAU - Magnani, Corrado
AU  - Magnani C
AD  - Center of Oncological Prevention (CPO) Piemonte and Unit of Medical Statistics 
      and Epidemiology, Department Translational Medicine, University of Piemonte 
      Orientale, Novara, Italy.
FAU - Ennas, Maria Grazia
AU  - Ennas MG
AD  - Department of Biomedical Science, University of Cagliari, Monserrato, Cagliari, 
      Italy.
FAU - Latte, Giancarlo
AU  - Latte G
AD  - Division of Hematology, S. Francesco Hospital, Nuoro, Italy.
FAU - Feldman, Andrew L
AU  - Feldman AL
AD  - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, 
      Minnesota.
FAU - Doo, Nicole Wong
AU  - Doo NW
AD  - Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, 
      Australia.
FAU - Giles, Graham G
AU  - Giles GG
AD  - Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, 
      Australia.
AD  - Centre for Epidemiology and Biostatistics, Melbourne School of Population and 
      Global Health, University of Melbourne, Melbourne, Victoria, Australia.
FAU - Southey, Melissa C
AU  - Southey MC
AD  - Genetic Epidemiology Laboratory, Department of Pathology, University of 
      Melbourne, Melbourne, Victoria, Australia.
FAU - Milne, Roger L
AU  - Milne RL
AD  - Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, 
      Australia.
AD  - Centre for Epidemiology and Biostatistics, Melbourne School of Population and 
      Global Health, University of Melbourne, Melbourne, Victoria, Australia.
FAU - Offit, Kenneth
AU  - Offit K
AD  - Department of Hematology, Rishospitalet, Copenhagen, Denmark.
FAU - Musinsky, Jacob
AU  - Musinsky J
AD  - Department of Hematology, Rishospitalet, Copenhagen, Denmark.
FAU - Arslan, Alan A
AU  - Arslan AA
AD  - Department of Obstetrics and Gynecology, New York University School of Medicine, 
      New York City, New York.
AD  - Department of Environmental Medicine, New York University School of Medicine, New 
      York City, New York.
AD  - Perlmutter Cancer Center, NYU Langone Medical Center, New York City, New York.
FAU - Purdue, Mark P
AU  - Purdue MP
AD  - Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
FAU - Adami, Hans-Olov
AU  - Adami HO
AD  - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 
      Stockholm, Sweden.
FAU - Melbye, Mads
AU  - Melbye M
AD  - Department of Epidemiology Research, Division of Health Surveillance and 
      Research, Statens Serum Institut, Copenhagen, Denmark.
AD  - Department of Medicine, Stanford University School of Medicine, Stanford, 
      Calfornia.
FAU - Glimelius, Bengt
AU  - Glimelius B
AD  - Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, 
      Sweden.
FAU - Conde, Lucia
AU  - Conde L
AD  - Bill Lyons Informatics Centre, UCL Cancer Institute, University College London, 
      London, United Kingdom.
FAU - Camp, Nicola J
AU  - Camp NJ
AD  - Department of Internal Medicine, Huntsman Cancer Institute, University of Utah 
      School of Medicine, Salt Lake City, Utah.
FAU - Glenn, Martha
AU  - Glenn M
AD  - Department of Internal Medicine, Huntsman Cancer Institute, University of Utah 
      School of Medicine, Salt Lake City, Utah.
FAU - Curtin, Karen
AU  - Curtin K
AD  - Department of Internal Medicine, Huntsman Cancer Institute, University of Utah 
      School of Medicine, Salt Lake City, Utah.
FAU - Clavel, Jacqueline
AU  - Clavel J
AD  - Epidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of 
      Research in Epidemiology and Statistics Sorbonne Paris Cite (CRESS), Paris, 
      France.
AD  - Universite Paris Descartes, Paris, France.
FAU - Monnereau, Alain
AU  - Monnereau A
AD  - Universite Paris Descartes, Paris, France.
AD  - Universite Paris Descartes, Paris, France.
AD  - Registre des hemopathies malignes de la Gironde, Institut Bergonie, University of 
      Bordeaux, Inserm, Team EPICENE, UMR 1219, France.
FAU - Cox, David G
AU  - Cox DG
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Imperial 
      College London, London, United Kingdom; Cancer Research Center of Lyon, INSERM 
      UMR1052, Center Leon Berard, Lyon, France.
FAU - Ghesquieres, Herve
AU  - Ghesquieres H
AD  - Universite Paris Descartes, Paris, France.
AD  - Laboratoire de Biologie Moleculaire de la Cellule UMR 5239, Centre National de la 
      Recherche Scientifique, Pierre benite Cedex, France.
FAU - Salles, Gilles
AU  - Salles G
AD  - Laboratoire de Biologie Moleculaire de la Cellule UMR 5239, Centre National de la 
      Recherche Scientifique, Pierre benite Cedex, France.
AD  - Department of Hematology, Hospices Civils De Lyon, Centre Hospitalier Lyon-Sud 
      and Universite Claude Bernard, Lyon, France.
FAU - Bofetta, Paulo
AU  - Bofetta P
AD  - The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York 
      City, New York.
FAU - Foretova, Lenka
AU  - Foretova L
AD  - Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer 
      Institute, MF MU, Brno, Czech Republic.
FAU - Staines, Anthony
AU  - Staines A
AD  - School of Nursing and Human Sciences, Dublin City University, Dublin, Ireland.
FAU - Davis, Scott
AU  - Davis S
AD  - Fred Hutchinson Cancer Research Center and School of Public Health and Community 
      Medicine, University of Washington, Seattle, Washington.
FAU - Severson, Richard K
AU  - Severson RK
AD  - Department of Family Medicine and Public Health Sciences, Wayne State University, 
      Detroit, Michigan.
FAU - Lan, Qing
AU  - Lan Q
AD  - Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
FAU - Brooks-Wilson, Angela
AU  - Brooks-Wilson A
AD  - Department of Biomedical Physiology and Kinesiology, Simon Fraser University, 
      Burnaby, British Columbia, Canada.
AD  - Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.
FAU - Smith, Martyn T
AU  - Smith MT
AD  - Division of Environmental Health Sciences, School of Public Health, University of 
      California, Berkeley, Berkeley, California.
FAU - Roman, Eve
AU  - Roman E
AD  - Department of Health Sciences, University of York, York, United Kingdom.
FAU - Kricker, Anne
AU  - Kricker A
AD  - Sydney School of Public Health, The University of Sydney, Sydney, Australia.
FAU - Zhang, Yawei
AU  - Zhang Y
AD  - Department of Surgery, Yale School of Medicine, New Haven, Connecticut.
AD  - Department of Environmental Health Sciences, Yale School of Public Health, New 
      Haven.
FAU - Kraft, Peter
AU  - Kraft P
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 
      Massachusetts.
AD  - Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, 
      Massachusetts.
FAU - Chanock, Stephen J
AU  - Chanock SJ
AD  - Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
FAU - Rothman, Nathaniel
AU  - Rothman N
AD  - Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
FAU - Hartge, Patricia
AU  - Hartge P
AD  - Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
FAU - Skibola, Christine F
AU  - Skibola CF
AD  - Department of Hematology and Medical Oncology, Emory University School of 
      Medicine, Atlanta, Georgia.
LA  - eng
GR  - 15037/LLR_/Blood Cancer UK/United Kingdom
GR  - N01 PC067009/CN/NCI NIH HHS/United States
GR  - P01 CA087969/CA/NCI NIH HHS/United States
GR  - R21 CA165923/CA/NCI NIH HHS/United States
GR  - P30 ES000260/ES/NIEHS NIH HHS/United States
GR  - P30 CA008748/CA/NCI NIH HHS/United States
GR  - U58 DP000807/DP/NCCDPHP CDC HHS/United States
GR  - UM1 CA167552/CA/NCI NIH HHS/United States
GR  - HHSN261201500005C/CA/NCI NIH HHS/United States
GR  - HHSN261201000026C/CA/NCI NIH HHS/United States
GR  - P30 CA016087/CA/NCI NIH HHS/United States
GR  - HHSN261201000140C/CA/NCI NIH HHS/United States
GR  - N01 PC067010/PC/NCI NIH HHS/United States
GR  - R01 CA098122/CA/NCI NIH HHS/United States
GR  - U01 HG007033/HG/NHGRI NIH HHS/United States
GR  - P30 CA086862/CA/NCI NIH HHS/United States
GR  - U01 CA167552/CA/NCI NIH HHS/United States
GR  - N01 PC067008/PC/NCI NIH HHS/United States
GR  - R01 CA148690/CA/NCI NIH HHS/United States
GR  - R01 CA154643/CA/NCI NIH HHS/United States
GR  - R01 CA062006/CA/NCI NIH HHS/United States
GR  - N01 PC065064/PC/NCI NIH HHS/United States
GR  - K08 CA134919/CA/NCI NIH HHS/United States
GR  - UL1 TR000135/TR/NCATS NIH HHS/United States
GR  - R01 CA098661/CA/NCI NIH HHS/United States
GR  - UM1 CA186107/CA/NCI NIH HHS/United States
GR  - P30 CA015083/CA/NCI NIH HHS/United States
GR  - R01 CA092153/CA/NCI NIH HHS/United States
GR  - HHSN261201000035I/CA/NCI NIH HHS/United States
GR  - HHSN261201000035C/PC/NCI NIH HHS/United States
GR  - HHSN261201000034C/CA/NCI NIH HHS/United States
GR  - P30 CA033572/CA/NCI NIH HHS/United States
GR  - P50 CA097274/CA/NCI NIH HHS/United States
GR  - R01 CA049449/CA/NCI NIH HHS/United States
GR  - R01 CA200703/CA/NCI NIH HHS/United States
GR  - N01CO12400/CA/NCI NIH HHS/United States
GR  - HHSN261200800001C/RC/CCR NIH HHS/United States
GR  - U01 CA049449/CA/NCI NIH HHS/United States
GR  - R03 CA179558/CA/NCI NIH HHS/United States
GR  - R01 CA149445/CA/NCI NIH HHS/United States
GR  - 001/WHO_/World Health Organization/International
GR  - R01 CA134674/CA/NCI NIH HHS/United States
GR  - CRUK_/Cancer Research UK/United Kingdom
GR  - U01 CA118444/CA/NCI NIH HHS/United States
GR  - HHSN261200800001E/CA/NCI NIH HHS/United States
GR  - P30 CA042014/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20180507
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Heterogeneity
MH  - Genome-Wide Association Study/methods
MH  - Heterozygote
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Lymphoma, Non-Hodgkin/*genetics
MH  - Male
MH  - Prospective Studies
PMC - PMC6065509
MID - NIHMS964604
EDAT- 2018/05/08 06:00
MHDA- 2019/08/30 06:00
PMCR- 2019/07/15
CRDT- 2018/05/09 06:00
PHST- 2017/10/12 00:00 [received]
PHST- 2018/02/07 00:00 [revised]
PHST- 2018/04/24 00:00 [accepted]
PHST- 2018/05/08 06:00 [pubmed]
PHST- 2019/08/30 06:00 [medline]
PHST- 2018/05/09 06:00 [entrez]
PHST- 2019/07/15 00:00 [pmc-release]
AID - 0008-5472.CAN-17-2900 [pii]
AID - 10.1158/0008-5472.CAN-17-2900 [doi]
PST - ppublish
SO  - Cancer Res. 2018 Jul 15;78(14):4086-4096. doi: 10.1158/0008-5472.CAN-17-2900. 
      Epub 2018 May 7.