PMID- 29735975
OWN - NLM
STAT- MEDLINE
DCOM- 20180928
LR  - 20181114
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 24
DP  - 2018 May 8
TI  - Efficacy of Acupuncture Therapy for Chemotherapy-Related Cognitive Impairment in 
      Breast Cancer Patients.
PG  - 2919-2927
LID - 10.12659/MSM.909712 [doi]
AB  - BACKGROUND Chemotherapy can cause adverse effects such as chemotherapy-related 
      cognitive impairment (CRCI). In this prospective study, the efficacy of 
      traditional Chinese medicine acupuncture therapy in relieving CRCI and its impact 
      on serum brain-derived neurotrophic factor (BDNF) are evaluated. MATERIAL AND 
      METHODS Eighty patients were randomly divided into a treatment group and a 
      control group with 40 patients in each group. The treatment group was treated at 
      the following acupuncture points: Baihui (DU20), Sishencong (EX-HN1), Shenting 
      (DU24), Zusanli (ST36), Taixi (K13), Dazhong (K14), and Juegu (GB39). Cognitive 
      function was assessed using the functional assessment of cancer treatment 
      cognition test (FACT-COG, version 3), the auditory-verbal learning test (AVLT), 
      the verbal fluency test (VFT), the symbol digit modality test (SDMT), the 
      clock-drawing test (CDT), and the trail-making test part B (TMT-B). In addition, 
      blood serum levels of BDNF were measured before and after treatment. Correlations 
      between change in BDNF levels and cognitive function were also analyzed. RESULTS 
      CRCI was ameliorated in the acupuncture treatment group, with scores on FACT-COG, 
      AVLT-recognition and CDT assessments all significantly increased (P<0.05 in all 
      cases). In addition, serum BDNF levels after acupuncture treatment were 
      significantly higher than before treatment ([i]t[/i]=3.242, [i]P[/i]<0.01). 
      Moreover, the level of BDNF was positively correlated with the total score of 
      FACT-COG, AVLT-recognition, and CDT ([i]r[/i]=0.694, 0.628, and 0.532, 
      respectively; all P<0.05). The control group showed no statistically significant 
      difference in any measures over the same period. CONCLUSIONS Acupuncture therapy 
      is effective in the treatment of CRCI in breast cancer patients through a 
      mechanism that may be related to an increase of BDNF.
FAU - Tong, Taishan
AU  - Tong T
AD  - Department of Psychology and Psychiatry, The Affiliated Wuxi Mental Health Center 
      of Nanjing Medical University, Wuxi, Jiangsu, China (mainland).
FAU - Pei, Chunqin
AU  - Pei C
AD  - Department of Acupuncture and Moxibustion, The Affiliated Hospital of Jiangnan 
      University, Wuxi, Jiangsu, China (mainland).
FAU - Chen, Jun
AU  - Chen J
AD  - Department of Acupuncture and Moxibustion, The Affiliated Hospital of Jiangnan 
      University, Wuxi, Jiangsu, China (mainland).
FAU - Lv, Qing
AU  - Lv Q
AD  - Department of Breast Surgery, The Affiliated Hospital of Jiangnan University, 
      Wuxi, Jiangsu, China (mainland).
FAU - Zhang, Fuquan
AU  - Zhang F
AD  - Department of Psychology and Psychiatry, The Affiliated Wuxi Mental Health Center 
      of Nanjing Medical University, Wuxi, Jiangsu, China (mainland).
FAU - Cheng, Zaohuo
AU  - Cheng Z
AD  - Department of Psychology and Psychiatry, The Affiliated Wuxi Mental Health Center 
      of Nanjing Medical University, Wuxi, Jiangsu, China (mainland).
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20180508
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - *Acupuncture Therapy
MH  - Antineoplastic Agents/pharmacology/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Breast Neoplasms/blood/*complications/*drug therapy/psychology
MH  - Cognitive Dysfunction/blood/*etiology/psychology/*therapy
MH  - Demography
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Treatment Outcome
PMC - PMC5963738
OTO - NOTNLM
OT  - Acupuncture - methods
OT  - Brain-Derived Neurotrophic Factor - chemical synthesis
OT  - Breast
OT  - mild cognitive impairment
EDAT- 2018/05/08 06:00
MHDA- 2018/10/03 06:00
PMCR- 2018/05/08
CRDT- 2018/05/09 06:00
PHST- 2018/05/09 06:00 [entrez]
PHST- 2018/05/08 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2018/05/08 00:00 [pmc-release]
AID - 909712 [pii]
AID - 10.12659/MSM.909712 [doi]
PST - epublish
SO  - Med Sci Monit. 2018 May 8;24:2919-2927. doi: 10.12659/MSM.909712.