PMID- 29736153
OWN - NLM
STAT- MEDLINE
DCOM- 20180924
LR  - 20201209
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2018
DP  - 2018
TI  - Tabetri (Tabebuia avellanedae Ethanol Extract) Ameliorates Atopic Dermatitis 
      Symptoms in Mice.
PG  - 9079527
LID - 10.1155/2018/9079527 [doi]
LID - 9079527
AB  - Tabebuia avellanedae has been traditionally used as an herbal remedy to alleviate 
      various diseases. However, the plant's pharmacological activity in allergic and 
      inflammatory diseases and its underlying mechanism are not fully understood. 
      Therefore, we investigated the pharmacological activity of Tabetri (T. 
      avellanedae ethanol extract (Ta-EE)) in the pathogenesis of AD. Its underlying 
      mechanism was explored using an AD mouse model and splenocytes isolated from this 
      model. Ta-EE ameliorated the AD symptoms without any toxicity and protected the 
      skin of 2,4-dinitrochlorobenzene- (DNCB-) induced AD mice from damage and 
      epidermal thickness. Ta-EE reduced the secreted levels of allergic and 
      proinflammatory cytokines, including histamine, immunoglobulin E (IgE), 
      interleukin- (IL-) 4, and interferon-gamma (IFN-gamma) in the DNCB-induced AD mice. 
      Ta-EE suppressed the mRNA expression of T helper 2-specific cytokines, IL-4 and 
      IL-5, and the proinflammatory cytokine IFN-gamma in the atopic dermatitis skin 
      lesions of AD mice. Moreover, Ta-EE suppressed the mRNA expression of IL-4, IL-5, 
      IFN-gamma, and another proinflammatory cytokine, IL-12, in the Con A-stimulated 
      splenocytes. It also suppressed IL-12 and IFN-gamma in the LPS-stimulated 
      splenocytes. Taken together, these results suggest that Ta-EE protects against 
      the development of AD through the inhibition of mRNA expression of T helper 
      2-specific cytokines and other proinflammatory cytokines.
FAU - Park, Jae Gwang
AU  - Park JG
AD  - Department of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic 
      of Korea.
FAU - Yi, Young-Su
AU  - Yi YS
AUID- ORCID: 0000-0002-7166-3659
AD  - Department of Pharmaceutical Engineering, Cheongju University, Cheongju 28503, 
      Republic of Korea.
FAU - Han, Sang Yun
AU  - Han SY
AD  - Department of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic 
      of Korea.
FAU - Hong, Yo Han
AU  - Hong YH
AD  - Department of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic 
      of Korea.
FAU - Yoo, Sulgi
AU  - Yoo S
AD  - Department of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic 
      of Korea.
FAU - Kim, Eunji
AU  - Kim E
AUID- ORCID: 0000-0002-1908-5310
AD  - Department of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic 
      of Korea.
FAU - Jeong, Seong-Gu
AU  - Jeong SG
AD  - Department of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic 
      of Korea.
FAU - Aravinthan, Adithan
AU  - Aravinthan A
AD  - College of Veterinary Medicine, Chonbuk National University, Iksan 54596, 
      Republic of Korea.
FAU - Baik, Kwang Soo
AU  - Baik KS
AD  - R&I Planning Department, Nutribiotech Co. Ltd., Seoul 06132, Republic of Korea.
FAU - Choi, Su Young
AU  - Choi SY
AD  - R&I Planning Department, Nutribiotech Co. Ltd., Seoul 06132, Republic of Korea.
FAU - Kim, Jung-Il
AU  - Kim JI
AD  - Department of Information Statistics, Kangwon National University, Chuncheon 
      24341, Republic of Korea.
FAU - Son, Young-Jin
AU  - Son YJ
AUID- ORCID: 0000-0002-6873-9181
AD  - Department of Pharmacy, Sunchon National University, Suncheon 57922, Republic of 
      Korea.
FAU - Kim, Jong-Hoon
AU  - Kim JH
AUID- ORCID: 0000-0002-4409-0592
AD  - College of Veterinary Medicine, Chonbuk National University, Iksan 54596, 
      Republic of Korea.
FAU - Cho, Jae Youl
AU  - Cho JY
AUID- ORCID: 0000-0001-8141-9927
AD  - Department of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic 
      of Korea.
LA  - eng
PT  - Journal Article
DEP - 20180315
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Dinitrochlorobenzene)
RN  - 0 (Interleukin-5)
RN  - 0 (Plant Extracts)
RN  - 207137-56-2 (Interleukin-4)
RN  - 3K9958V90M (Ethanol)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Dermatitis, Atopic/chemically induced/*drug therapy
MH  - Dinitrochlorobenzene/toxicity
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Ethanol/chemistry
MH  - Interferon-gamma/metabolism
MH  - Interleukin-4/metabolism
MH  - Interleukin-5/metabolism
MH  - Male
MH  - Mice
MH  - Plant Extracts/chemistry/*therapeutic use
MH  - Real-Time Polymerase Chain Reaction
MH  - Tabebuia/*chemistry
PMC - PMC5874978
EDAT- 2018/05/08 06:00
MHDA- 2018/09/25 06:00
PMCR- 2018/03/15
CRDT- 2018/05/09 06:00
PHST- 2017/10/01 00:00 [received]
PHST- 2018/01/03 00:00 [accepted]
PHST- 2018/05/09 06:00 [entrez]
PHST- 2018/05/08 06:00 [pubmed]
PHST- 2018/09/25 06:00 [medline]
PHST- 2018/03/15 00:00 [pmc-release]
AID - 10.1155/2018/9079527 [doi]
PST - epublish
SO  - Mediators Inflamm. 2018 Mar 15;2018:9079527. doi: 10.1155/2018/9079527. 
      eCollection 2018.