PMID- 29736405
OWN - NLM
STAT- MEDLINE
DCOM- 20180910
LR  - 20220317
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2018
DP  - 2018
TI  - Renal Evaluation in Common Variable Immunodeficiency.
PG  - 5841031
LID - 10.1155/2018/5841031 [doi]
LID - 5841031
AB  - INTRODUCTION: Common variable immunodeficiency (CVID) comprises a heterogeneous 
      group of disorders characterized by impaired antibody production. Kidney 
      involvement in CVID is described in isolated and sporadic case reports. The 
      objective of this study was to study the renal function pattern in CVID patients 
      through glomerular and tubular function tests. METHODS: Study of 12 patients with 
      CVID diagnosis and 12 healthy control individuals. Glomerular filtration rate 
      (GFR), fractional excretion of sodium (FE(Na(+)) ) and potassium (FE(K(+)) ), 
      urinary concentration, and acidification capacity were measured. In addition, 
      microalbuminuria and urinary monocyte chemoattractant protein-1 (MCP-1) were 
      evaluated as markers of selectivity of the glomerular barrier and inflammation, 
      respectively. RESULTS: In relation to glomerular markers, all CVID patients had 
      normal GFR (>90 mL/min/1.73 m(2)), and microalbuminuria and urinary MCP-1 levels 
      were also similar to those of controls. Interestingly, CVID patients had reduced 
      urinary concentration capacity, as demonstrated by lower U/P(Osm) ratio, when 
      compared to controls. Also, while all control subjects achieved a urinary pH less 
      than 5.3, no CVID patients showed a decrease in urinary pH to such levels in 
      response to acid loading with CaCl(2), characterizing impaired urinary 
      acidification capacity. CONCLUSION: Patients showed a trend towards an elevated 
      prevalence of tubular dysfunction, mainly related to urinary acidification and 
      concentration capacities.
FAU - Capistrano, Giovany Gomes
AU  - Capistrano GG
AD  - Medical Sciences Postgraduate Program, Department of Clinical Medicine, Federal 
      University of Ceara, Fortaleza, CE, Brazil.
FAU - Meneses, Gdayllon Cavalcante
AU  - Meneses GC
AD  - Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal 
      University of Ceara, Fortaleza, CE, Brazil.
FAU - de Oliveira Neves, Fernanda Macedo
AU  - de Oliveira Neves FM
AD  - Medical Sciences Postgraduate Program, Department of Clinical Medicine, Federal 
      University of Ceara, Fortaleza, CE, Brazil.
FAU - de Almeida Leitao, Renata
AU  - de Almeida Leitao R
AD  - Medical Course, Universidade de Fortaleza (UNIFOR), Fortaleza, CE, Brazil.
FAU - Martins, Alice Maria Costa
AU  - Martins AMC
AUID- ORCID: 0000-0001-8160-2027
AD  - Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal 
      University of Ceara, Fortaleza, CE, Brazil.
FAU - Liborio, Alexandre Braga
AU  - Liborio AB
AUID- ORCID: 0000-0002-0409-6113
AD  - Medical Sciences Postgraduate Program, Department of Clinical Medicine, Federal 
      University of Ceara, Fortaleza, CE, Brazil.
AD  - Medical Course, Universidade de Fortaleza (UNIFOR), Fortaleza, CE, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20180315
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, CCR2)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Chemokine CCL2
MH  - Common Variable Immunodeficiency/diagnosis/*metabolism/pathology
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Kidney/*pathology
MH  - Kidney Diseases/diagnosis/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Receptors, CCR2/metabolism
MH  - Respiratory Function Tests
MH  - Young Adult
PMC - PMC5874972
EDAT- 2018/05/08 06:00
MHDA- 2018/09/11 06:00
PMCR- 2018/03/15
CRDT- 2018/05/09 06:00
PHST- 2017/06/19 00:00 [received]
PHST- 2017/12/21 00:00 [revised]
PHST- 2018/01/08 00:00 [accepted]
PHST- 2018/05/09 06:00 [entrez]
PHST- 2018/05/08 06:00 [pubmed]
PHST- 2018/09/11 06:00 [medline]
PHST- 2018/03/15 00:00 [pmc-release]
AID - 10.1155/2018/5841031 [doi]
PST - epublish
SO  - J Immunol Res. 2018 Mar 15;2018:5841031. doi: 10.1155/2018/5841031. eCollection 
      2018.