PMID- 29736575
OWN - NLM
STAT- MEDLINE
DCOM- 20181106
LR  - 20181106
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1059
DP  - 2018
TI  - Nanoparticles-Based Systems for Osteochondral Tissue Engineering.
PG  - 209-217
LID - 10.1007/978-3-319-76735-2_9 [doi]
AB  - Osteochondral lesions represent one of the major causes of disabilities in the 
      world. These defects are due to degenerative or inflammatory arthritis, but both 
      affect the articular cartilage and the underlying subchondral bone. Defects from 
      trauma or degenerative pathology frequently cause severe pain, joint deformity, 
      and loss of joint motion. Osteochondral defects are a significant challenge in 
      orthopedic surgery, due to the cartilage complexity and unique structure, as well 
      as its exposure to high pressure and motion. Although there are treatments 
      routinely performed in the clinical practice, they present several limitations. 
      Tissue engineering can be a suitable alternative for osteochondral defects since 
      bone and cartilage engineering had experienced a notable advance over the years. 
      Allied with nanotechnology, osteochondral tissue engineering (OCTE) can be 
      leveled up, being possible to create advanced structures similar to the OC 
      tissue. In this chapter, the current strategies using nanoparticles-based systems 
      are overviewed. The results of the studies herein considered confirm that 
      advanced nanomaterials will undoubtedly play a crucial role in the design of 
      strategies for treatment of osteochondral defects in the near future.
FAU - Oliveira, Isabel
AU  - Oliveira I
AD  - 3B's Research Group - Biomolecules, Biodegradables and Biomimetics, University of 
      Minho, Headquarters of the European Institute of Excellence on Tissue Engineering 
      and Regenerative Medicine, Barco, Guimaraes, Portugal.
AD  - ICVS/3B's - PT Government Associate Laboratory, Braga/Guimaraes, Portugal.
FAU - Vieira, Silvia
AU  - Vieira S
AD  - 3B's Research Group - Biomolecules, Biodegradables and Biomimetics, University of 
      Minho, Headquarters of the European Institute of Excellence on Tissue Engineering 
      and Regenerative Medicine, Barco, Guimaraes, Portugal.
AD  - ICVS/3B's - PT Government Associate Laboratory, Braga/Guimaraes, Portugal.
FAU - Oliveira, J Miguel
AU  - Oliveira JM
AD  - 3B's Research Group - Biomolecules, Biodegradables and Biomimetics, University of 
      Minho, Headquarters of the European Institute of Excellence on Tissue Engineering 
      and Regenerative Medicine, Barco, Guimaraes, Portugal. 
      miguel.oliveira@dep.uminho.pt.
AD  - ICVS/3B's - PT Government Associate Laboratory, Braga/Guimaraes, Portugal. 
      miguel.oliveira@dep.uminho.pt.
AD  - The Discoveries Center for Regenerative and Precision Medicine, Headquarters at 
      University of Minho, Barco/Guimaraes, Portugal. miguel.oliveira@dep.uminho.pt.
FAU - Reis, Rui L
AU  - Reis RL
AD  - 3B's Research Group - Biomolecules, Biodegradables and Biomimetics, University of 
      Minho, Headquarters of the European Institute of Excellence on Tissue Engineering 
      and Regenerative Medicine, Barco, Guimaraes, Portugal.
AD  - ICVS/3B's - PT Government Associate Laboratory, Braga/Guimaraes, Portugal.
AD  - The Discoveries Center for Regenerative and Precision Medicine, Headquarters at 
      University of Minho, Barco/Guimaraes, Portugal.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Pharmaceutical Vehicles)
SB  - IM
MH  - Bone Diseases/*therapy
MH  - Cartilage Diseases/*therapy
MH  - Cell Tracking/methods
MH  - Drug Delivery Systems
MH  - Humans
MH  - Nanoparticles/*therapeutic use
MH  - Pharmaceutical Vehicles
MH  - Tissue Engineering/*methods
MH  - Tissue Scaffolds
OTO - NOTNLM
OT  - Articular cartilage
OT  - Nanoparticles
OT  - Osteochondral defects
OT  - Subchondral bone
EDAT- 2018/05/08 06:00
MHDA- 2018/11/07 06:00
CRDT- 2018/05/09 06:00
PHST- 2018/05/09 06:00 [entrez]
PHST- 2018/05/08 06:00 [pubmed]
PHST- 2018/11/07 06:00 [medline]
AID - 10.1007/978-3-319-76735-2_9 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2018;1059:209-217. doi: 10.1007/978-3-319-76735-2_9.