PMID- 29737093
OWN - NLM
STAT- MEDLINE
DCOM- 20190108
LR  - 20190108
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 49
IP  - 1
DP  - 2018 Jan
TI  - [Serum Uric Acid and Islet beta-cell Function in Patients with Pre-diabetes and Type 
      2 Diabetes Mellitus].
PG  - 69-73
AB  - OBJECTIVE: To determine the correlation between serum uric acid (SUA) and insulin 
      secretion function in patients with pre-diabetes and type-2 diabetes mellitus 
      (T2DM). METHODS: A total of 4 112 adult people participated in this study. They 
      were divided into three groups according to the results of oral glucose tolerance 
      test (OGTT): 493 with normal glucose regulation (NGR),1 251 with impaired glucose 
      regulation (IGR),and 2 368 with T2DM. Their levels of SUA,fasting insulin 
      (FIns),2 h post-meal insulin (2 h-Ins),and insulin resistance index (HOMA-IR) 
      were determined. Correlations between SUA and insulin secretion and HOMA-IR were 
      estimated. RESULTS: IGR patients had higher levels of SUA and 2 h-Ins compared 
      with those with NGR and T2DM ( P<0.000 1). T2DM patients had higher levels of 
      FIns,glucosylated hemoglobin (HbA1c) and HOMA-IR compared with those with NGR and 
      IGR ( P<0.000 1). In both male and female participants,the highest level of 2 
      h-Ins appeared in those with IGR,while T2DM had the highest level of HOMA-IA and 
      HbA1c. FIns,2 h-Ins and HOMA-IR increased with SUA in both patients with IGR and 
      T2DM. HbA1c decreased with SUA in T2DM patients. CONCLUSION: High serum SUA is 
      correlated with islet beta-cell dysfunction. It may become an indicator of 
      progression from pre-diabetes to T2DM.
CI  - CopyrightCopyright(c) by Editorial Board of Journal of Sichuan University (Medical 
      Science Edition).
FAU - Wu, Yi-Tian
AU  - Wu YT
AD  - Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu 
      610041,China.
FAU - He, He
AU  - He H
AD  - Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu 
      610041,China.
FAU - Wang, Xia
AU  - Wang X
AD  - Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu 
      610041,China.
FAU - Zhang, Mei
AU  - Zhang M
AD  - Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu 
      610041,China.
FAU - An, Zhen-Mei
AU  - An ZM
AD  - Department of Endocrinology and Metabolism,West China Hospital,Sichuan 
      University,Chengdu 610041,China.
FAU - Huang, Heng-Jian
AU  - Huang HJ
AD  - Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu 
      610041,China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Blood Glucose
MH  - Diabetes Mellitus, Type 2/*blood/physiopathology
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Islets of Langerhans/cytology/*pathology
MH  - Male
MH  - Prediabetic State/*blood/physiopathology
MH  - Uric Acid/*blood
OTO - NOTNLM
OT  - HOMA-IR
OT  - IGR
OT  - Insulin
OT  - SUA
OT  - T2DM
EDAT- 2018/05/08 06:00
MHDA- 2019/01/09 06:00
CRDT- 2018/05/09 06:00
PHST- 2018/05/09 06:00 [entrez]
PHST- 2018/05/08 06:00 [pubmed]
PHST- 2019/01/09 06:00 [medline]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 Jan;49(1):69-73.