PMID- 29737438
OWN - NLM
STAT- MEDLINE
DCOM- 20190213
LR  - 20190215
IS  - 1573-6792 (Electronic)
IS  - 0896-0267 (Print)
IS  - 0896-0267 (Linking)
VI  - 31
IP  - 5
DP  - 2018 Sep
TI  - Variability and Reliability of Paired-Pulse Depression and Cortical Oscillation 
      Induced by Median Nerve Stimulation.
PG  - 780-794
LID - 10.1007/s10548-018-0648-5 [doi]
AB  - Paired-pulse depression (PPD) has been widely used to investigate the functional 
      profiles of somatosensory cortical inhibition. However, PPD induced by 
      somatosensory stimulation is variable, and the reasons for between- and 
      within-subject PPD variability remains unclear. Therefore, the purpose of this 
      study was to clarify the factors influencing PPD variability induced by 
      somatosensory stimulation. The study participants were 19 healthy volunteers. 
      First, we investigated the relationship between the PPD ratio of each component 
      (N20m, P35m, and P60m) of the somatosensory magnetic field, and the alpha, beta, 
      and gamma band changes in power [event-related desynchronization (ERD) and 
      event-related synchronization (ERS)] induced by median nerve stimulation. Second, 
      because brain-derived neurotrophic factor (BDNF) gene polymorphisms reportedly 
      influence the PPD ratio, we assessed whether BDNF genotype influences PPD ratio 
      variability. Finally, we evaluated the test-retest reliability of PPD and the 
      alpha, beta, and gamma ERD/ERS induced by somatosensory stimulation. Significant 
      positive correlations were observed between the P60m_PPD ratio and beta power 
      change, and the P60m_PPD ratio was significantly smaller for the beta ERD group 
      than for the beta ERS group. P35m_PPD was found to be robust and highly 
      reproducible; however, P60m_PPD reproducibility was poor. In addition, the ICC 
      values for alpha, beta, and gamma ERD/ERS were 0.680, 0.760, and 0.552 
      respectively. These results suggest that the variability of PPD for the P60m 
      deflection may be influenced by the ERD/ERS magnitude, which is induced by median 
      nerve stimulation.
FAU - Onishi, Hideaki
AU  - Onishi H
AD  - Institute for Human Movement and Medical Sciences, Niigata University of Health 
      and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 950-3198, Japan. 
      onishi@nuhw.ac.jp.
FAU - Otsuru, Naofumi
AU  - Otsuru N
AD  - Institute for Human Movement and Medical Sciences, Niigata University of Health 
      and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 950-3198, Japan.
FAU - Kojima, Sho
AU  - Kojima S
AD  - Institute for Human Movement and Medical Sciences, Niigata University of Health 
      and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 950-3198, Japan.
FAU - Miyaguchi, Shota
AU  - Miyaguchi S
AD  - Institute for Human Movement and Medical Sciences, Niigata University of Health 
      and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 950-3198, Japan.
FAU - Saito, Kei
AU  - Saito K
AD  - Institute for Human Movement and Medical Sciences, Niigata University of Health 
      and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 950-3198, Japan.
FAU - Inukai, Yasuto
AU  - Inukai Y
AD  - Institute for Human Movement and Medical Sciences, Niigata University of Health 
      and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 950-3198, Japan.
FAU - Yamashiro, Koya
AU  - Yamashiro K
AD  - Institute for Human Movement and Medical Sciences, Niigata University of Health 
      and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 950-3198, Japan.
FAU - Sato, Daisuke
AU  - Sato D
AD  - Institute for Human Movement and Medical Sciences, Niigata University of Health 
      and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 950-3198, Japan.
FAU - Tamaki, Hiroyuki
AU  - Tamaki H
AD  - Institute for Human Movement and Medical Sciences, Niigata University of Health 
      and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 950-3198, Japan.
FAU - Shirozu, Hiroshi
AU  - Shirozu H
AD  - Department of Functional Neurosurgery, Nishi-Niigata Chuo National Hospital, 
      1-14-1 Masago, Nishi-ku, Niigata, 950-2085, Japan.
FAU - Kameyama, Shigeki
AU  - Kameyama S
AD  - Department of Functional Neurosurgery, Nishi-Niigata Chuo National Hospital, 
      1-14-1 Masago, Nishi-ku, Niigata, 950-2085, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180508
PL  - United States
TA  - Brain Topogr
JT  - Brain topography
JID - 8903034
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Cortical Synchronization
MH  - Electric Stimulation
MH  - Electrophysiological Phenomena/*genetics/*physiology
MH  - Evoked Potentials, Somatosensory/physiology
MH  - Female
MH  - Genotype
MH  - Healthy Volunteers
MH  - Humans
MH  - Magnetoencephalography/*methods
MH  - Male
MH  - Median Nerve/*physiology
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic/genetics
MH  - Reproducibility of Results
MH  - Somatosensory Cortex/*physiology
MH  - Young Adult
PMC - PMC6097743
OTO - NOTNLM
OT  - Event-related desynchronization
OT  - Event-related synchronization
OT  - Magnetoencephalography
OT  - SEF
OT  - Sensory gating
COIS- The authors declare no competing financial interests.
EDAT- 2018/05/09 06:00
MHDA- 2019/02/14 06:00
PMCR- 2018/05/08
CRDT- 2018/05/09 06:00
PHST- 2017/12/25 00:00 [received]
PHST- 2018/05/02 00:00 [accepted]
PHST- 2018/05/09 06:00 [pubmed]
PHST- 2019/02/14 06:00 [medline]
PHST- 2018/05/09 06:00 [entrez]
PHST- 2018/05/08 00:00 [pmc-release]
AID - 10.1007/s10548-018-0648-5 [pii]
AID - 648 [pii]
AID - 10.1007/s10548-018-0648-5 [doi]
PST - ppublish
SO  - Brain Topogr. 2018 Sep;31(5):780-794. doi: 10.1007/s10548-018-0648-5. Epub 2018 
      May 8.