PMID- 29737871
OWN - NLM
STAT- MEDLINE
DCOM- 20190306
LR  - 20190306
IS  - 1366-5804 (Electronic)
IS  - 1354-750X (Linking)
VI  - 23
IP  - 7
DP  - 2018 Nov
TI  - Circulating biomarkers of hypertrophy and fibrosis in patients with hypertrophic 
      cardiomyopathy assessed by cardiac magnetic resonance.
PG  - 676-682
LID - 10.1080/1354750X.2018.1474261 [doi]
AB  - BACKGROUND: Myocardial fibrosis in hypertrophic cardiomyopathy (HCM) is 
      associated with worse clinical outcomes. The availability of circulating 
      biomarkers of myocardial fibrosis and hypertrophy would be helpful in clinical 
      practice. OBJECTIVE: The aim of this study was to evaluate usefulness of various 
      biomarkers of myocardial fibrosis and hypertrophy in HCM. METHODS: Levels of 
      biomarkers: soluble ST2 (sST2), galectin-3 (Gal-3), growth differentiation 
      factor-15 (GDF-15), NT-proBNP and high-sensitivity cardiac troponin T (hs-cTnT) 
      were measured in 60 patients with HCM. All patients underwent cardiac magnetic 
      resonance imaging to calculate parameters of hypertrophy and fibrosis. RESULTS: 
      We observed positive correlations among sST2 levels and left ventricular mass 
      (LVM) (r = 0.32, p = 0.012), LV mass indexed for the body surface area (LVMI) 
      (r = 0.27, p = 0.036) and maximal wall thickness (MWT) (r = 0.31, p = 0.015). No 
      correlation was found between Gal-3 and GDF-15 levels and hypertrophy and 
      fibrosis parameters. We observed positive correlations among hs-cTnT levels and 
      LVM (r = 0.58, p < 0.0001), LVMI (r = 0.48, p = 0.0001), MWT (r = 0.31, 
      p = 0.015) and late gadolinium enhancement (LGE) mass (r = 0.37, p = 0.003). 
      There were positive correlations between NT-proBNP levels and LVM (r = 0.33, 
      p = 0.01), LVMI (r = 0.41, p = 0.001), MWT (r = 0.42, p < 0.001) and LGE mass 
      (r = 0.44, p < 0.001). CONCLUSIONS: Although no correlation between sST2 levels 
      and myocardial fibrosis was found, sST2 may provide some additional information 
      about hypertrophy extension. NT-proBNP and hs-cTnT are useful biomarkers in 
      assessment of hypertrophy and fibrosis in HCM.
FAU - Gawor, Monika
AU  - Gawor M
AD  - a Department of Cardiomyopathy , Institute of Cardiology , Warsaw , Poland.
FAU - Spiewak, Mateusz
AU  - Spiewak M
AD  - b Cardiac Magnetic Resonance Unit, Institute of Cardiology , Warsaw , Poland.
FAU - Kubik, Agata
AU  - Kubik A
AD  - b Cardiac Magnetic Resonance Unit, Institute of Cardiology , Warsaw , Poland.
FAU - Wrobel, Aleksandra
AU  - Wrobel A
AD  - c Department of Medical Biology , Institute of Cardiology , Warsaw , Poland.
FAU - Lutynska, Anna
AU  - Lutynska A
AD  - c Department of Medical Biology , Institute of Cardiology , Warsaw , Poland.
FAU - Marczak, Magdalena
AU  - Marczak M
AD  - b Cardiac Magnetic Resonance Unit, Institute of Cardiology , Warsaw , Poland.
FAU - Grzybowski, Jacek
AU  - Grzybowski J
AD  - a Department of Cardiomyopathy , Institute of Cardiology , Warsaw , Poland.
LA  - eng
PT  - Journal Article
DEP - 20180523
PL  - England
TA  - Biomarkers
JT  - Biomarkers : biochemical indicators of exposure, response, and susceptibility to 
      chemicals
JID - 9606000
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (Troponin T)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/*blood
MH  - Cardiomyopathy, Hypertrophic/blood/*diagnostic imaging/pathology
MH  - Fibrosis/blood/diagnosis
MH  - Humans
MH  - Hypertrophy/blood/diagnosis
MH  - Magnetic Resonance Imaging
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Troponin T/*blood
OTO - NOTNLM
OT  - GDF-15
OT  - Hypertrophic cardiomyopathy
OT  - galectin-3
OT  - myocardial fibrosis
OT  - sST2
EDAT- 2018/05/09 06:00
MHDA- 2019/03/07 06:00
CRDT- 2018/05/09 06:00
PHST- 2018/05/09 06:00 [pubmed]
PHST- 2019/03/07 06:00 [medline]
PHST- 2018/05/09 06:00 [entrez]
AID - 10.1080/1354750X.2018.1474261 [doi]
PST - ppublish
SO  - Biomarkers. 2018 Nov;23(7):676-682. doi: 10.1080/1354750X.2018.1474261. Epub 2018 
      May 23.