PMID- 29738391
OWN - NLM
STAT- MEDLINE
DCOM- 20191009
LR  - 20191010
IS  - 1537-4505 (Electronic)
IS  - 1531-7129 (Linking)
VI  - 39
IP  - 5
DP  - 2018 Jun
TI  - Comparison of Clinical Characteristics and Surgical Outcomes of Cystic and Solid 
      Vestibular Schwannomas.
PG  - e381-e386
LID - 10.1097/MAO.0000000000001813 [doi]
AB  - OBJECTIVE: The aim of this study was to compare the clinical characteristics of 
      cystic vestibular schwannomas (CVSs) and solid vestibular schwannomas (SVSs). 
      STUDY DESIGN: Retrospective review. SETTING: Tertiary care center. PATIENTS: A 
      total of 220 patients who underwent microsurgery for vestibular schwannomas 
      between 2007 and 2016. INTERVENTION: CVSs were defined as cystic components >/=1/3 
      of total tumor volume based on automated volume measurement. Tumors larger than 
      5 cm were defined as large tumors. MAIN OUTCOME MEASURES: Clinical 
      characteristics and surgical outcomes, including preoperative symptoms, hearing 
      threshold, vestibular function, tumor volume, extent of resection, facial nerve 
      outcomes, and nonfacial complications were evaluated. RESULTS: Tumor volume was 
      significantly larger in CVSs (20.44 +/- 13.85 cm in CVSs; 4.75 +/- 6.48 cm in SVSs, 
      p < 0.001) and the proportion of larger tumors was also greater in CVSs (66.0% in 
      CVSs; 11.4% in SVSs, p < 0.001). Preoperative dizziness was highly prevalent in 
      CVSs (32.1% in CVSs; 18.6% in SVSs, p = 0.038) and postoperative facial nerve 
      outcomes were significantly worse in CVSs (67.9% favorable rate in CVSs; 87.4% 
      favorable rate in SVSs, p = 0.001). When the comparison was limited to large 
      tumors, no clinical characteristics or surgical outcomes were significantly 
      different. Tumor volume had a greater effect than tumor type on the surgical 
      outcomes. The odds ratios for subtotal resection and unfavorable facial nerve 
      function with a large tumor were 5.77 (confidence interval [CI]: 1.52-21.95, 
      p = 0.010) and 5.34 (CI: 1.41-20.22, p = 0.014), respectively. CONCLUSION: CVSs 
      tend to be larger than SVSs. Tumor volume, not cystic component, is thought to be 
      a major determinant of surgical outcomes.
FAU - Han, Ji Hyuk
AU  - Han JH
AD  - Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul.
FAU - Baek, Kwang Ha
AU  - Baek KH
AD  - Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul.
FAU - Lee, Young Woo
AU  - Lee YW
AD  - Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul.
FAU - Hur, Young Kyun
AU  - Hur YK
AD  - Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul.
FAU - Kim, Hyun Ji
AU  - Kim HJ
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Inha University College 
      of Medicine, Incheon, Korea.
FAU - Moon, In Seok
AU  - Moon IS
AD  - Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Otol Neurotol
JT  - Otology & neurotology : official publication of the American Otological Society, 
      American Neurotology Society [and] European Academy of Otology and Neurotology
JID - 100961504
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuroma, Acoustic/*pathology/*surgery
MH  - Neurosurgical Procedures/*adverse effects
MH  - Postoperative Complications/epidemiology/*etiology
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2018/05/09 06:00
MHDA- 2019/10/11 06:00
CRDT- 2018/05/09 06:00
PHST- 2018/05/09 06:00 [entrez]
PHST- 2018/05/09 06:00 [pubmed]
PHST- 2019/10/11 06:00 [medline]
AID - 00129492-201806000-00032 [pii]
AID - 10.1097/MAO.0000000000001813 [doi]
PST - ppublish
SO  - Otol Neurotol. 2018 Jun;39(5):e381-e386. doi: 10.1097/MAO.0000000000001813.