PMID- 29738768
OWN - NLM
STAT- MEDLINE
DCOM- 20181009
LR  - 20181009
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 501
IP  - 1
DP  - 2018 Jun 18
TI  - Differential effects of voluntary wheel running and toy rotation on the mRNA 
      expression of neurotrophic factors and FKBP5 in a post-traumatic stress disorder 
      rat model with the shuttle-box task.
PG  - 307-312
LID - S0006-291X(18)31072-6 [pii]
LID - 10.1016/j.bbrc.2018.05.023 [doi]
AB  - Life-threatening experiences can result in the development of post-traumatic 
      stress disorder. We have developed an animal model for post-traumatic stress 
      disorder (PTSD) using a shuttle box in rats. In this paradigm, the rats were 
      exposed to inescapable foot-shock stress (IS) in a shuttle box, and then an 
      avoidance/escape task was performed in the same box 2 weeks after IS. A previous 
      study using this paradigm revealed that environmental enrichment (EE) ameliorated 
      avoidance/numbing-like behaviors, but not hyperarousal-like behaviors, and EE 
      also elevated hippocampal brain-derived neurotrophic factor (BDNF) expression. 
      However, the differential effects of EE components, i.e., running wheel (RW) or 
      toy rotation, on PTSD-like behaviors has remained unclear. In this experiment, we 
      demonstrated that RW, toy rotation, and EE (containing RW and toy rotation) 
      ameliorated avoidance/numbing-like behaviors, induced learning of avoidance 
      responses, and improved depressive-like behaviors in traumatized rats. The RW 
      increased the hippocampal mRNA expression of neurotrophic factors, especially 
      BDNF and glial-cell derived neurotrophic factor. Toy rotation influenced FK506 
      binding protein 5 mRNA expression, which is believed to be a regulator of the 
      hypothalamic-pituitary-adrenal (HPA)-axis system, in the hippocampus and 
      amygdala. This is the first report to elucidate the differential mechanistic 
      effects of RW and toy rotation. The former appears to exert its effects via 
      neurotrophic factors, while the latter exerts its effects via the HPA axis. 
      Further studies will lead to a better understanding of the influence of 
      environmental factors on PTSD.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Tanichi, Masaaki
AU  - Tanichi M
AD  - Department of Psychiatry, National Defense Medical College, Saitama, 359-8513, 
      Japan.
FAU - Toda, Hiroyuki
AU  - Toda H
AD  - Department of Psychiatry, National Defense Medical College, Saitama, 359-8513, 
      Japan. Electronic address: toda1973@ndmc.ac.jp.
FAU - Shimizu, Kunio
AU  - Shimizu K
AD  - Division of Behavioral Science, National Defense Medical College Research 
      Institute, Saitama, 359-8513, Japan.
FAU - Koga, Minori
AU  - Koga M
AD  - Department of Psychiatry, National Defense Medical College, Saitama, 359-8513, 
      Japan.
FAU - Saito, Taku
AU  - Saito T
AD  - Department of Psychiatry, National Defense Medical College, Saitama, 359-8513, 
      Japan.
FAU - Enomoto, Shingo
AU  - Enomoto S
AD  - Department of Psychiatry, National Defense Medical College, Saitama, 359-8513, 
      Japan.
FAU - Boku, Shuken
AU  - Boku S
AD  - Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, 
      650-0017, Japan.
FAU - Asai, Fumiho
AU  - Asai F
AD  - Department of Psychiatry, National Defense Medical College, Saitama, 359-8513, 
      Japan.
FAU - Mitsui, Yumi
AU  - Mitsui Y
AD  - Division of Behavioral Science, National Defense Medical College Research 
      Institute, Saitama, 359-8513, Japan.
FAU - Nagamine, Masanori
AU  - Nagamine M
AD  - Division of Behavioral Science, National Defense Medical College Research 
      Institute, Saitama, 359-8513, Japan.
FAU - Fujita, Masanori
AU  - Fujita M
AD  - Division of Environmental Medicine, National Defense Medical College Research 
      Institute, Saitama, 359-8513, Japan.
FAU - Yoshino, Aihide
AU  - Yoshino A
AD  - Department of Psychiatry, National Defense Medical College, Saitama, 359-8513, 
      Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180508
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Gdnf protein, rat)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (RNA, Messenger)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - EC 5.2.1.- (Tacrolimus Binding Proteins)
RN  - EC 5.2.1.8 (tacrolimus binding protein 5)
SB  - IM
MH  - Amygdala/metabolism
MH  - Animals
MH  - Avoidance Learning
MH  - Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Disease Models, Animal
MH  - Escape Reaction
MH  - Glial Cell Line-Derived Neurotrophic Factor/genetics
MH  - Hippocampus/metabolism
MH  - Hypothalamo-Hypophyseal System/metabolism
MH  - Male
MH  - Motor Activity
MH  - Nerve Growth Factor/genetics
MH  - Nerve Growth Factors/*genetics
MH  - Pituitary-Adrenal System/metabolism
MH  - Prefrontal Cortex/metabolism
MH  - RNA, Messenger/*genetics/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Stress Disorders, Post-Traumatic/*genetics/*metabolism/psychology
MH  - Tacrolimus Binding Proteins/*genetics
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Enriched environment
OT  - FK506 binding protein 5
OT  - Glial-cell derived neurotrophic factor
OT  - Hypothalamic-pituitary-adrenal axis
OT  - Post-traumatic stress disorder
EDAT- 2018/05/09 06:00
MHDA- 2018/10/10 06:00
CRDT- 2018/05/09 06:00
PHST- 2018/04/24 00:00 [received]
PHST- 2018/05/04 00:00 [accepted]
PHST- 2018/05/09 06:00 [pubmed]
PHST- 2018/10/10 06:00 [medline]
PHST- 2018/05/09 06:00 [entrez]
AID - S0006-291X(18)31072-6 [pii]
AID - 10.1016/j.bbrc.2018.05.023 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2018 Jun 18;501(1):307-312. doi: 
      10.1016/j.bbrc.2018.05.023. Epub 2018 May 8.