PMID- 29739038
OWN - NLM
STAT- MEDLINE
DCOM- 20190916
LR  - 20221207
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 64
IP  - 5
DP  - 2018 May 1
TI  - Effects of Analyzer Detection Method, Ethnicity, and Reference Individuals on 
      Reference Interval of Immature Platelet Fraction.
PG  - 699-708
LID - 10.7754/Clin.Lab.2018.171025 [doi]
AB  - BACKGROUND: Immature platelet fraction (IPF) is a new biomarker for 
      thrombopoiesis and inflammation. However, the reference interval (RI) is wildly 
      discrepant among published reports. This study aimed to establish the RI of IPF 
      for a population in Taiwan and evaluate the effects the detection method of the 
      analyzer, ethnicity, and reference individuals have on the RI of IPF. METHODS: 
      The RI of absolute IPF (A-IPF) and IPF% were established with healthy subjects 
      from the outpatient services of the Health Management Department of Taichung 
      Veterans General Hospital between January 1, 2015 and March 1, 2016. These values 
      were used along with published reports for meta-analysis. RESULTS: A-IPF (109/L) 
      and IPF% of Taiwanese were 6.9 - 7.6 and 3.1 - 3.4, respectively. Significant 
      differences were found when performing paired comparisons of the RI of A-IPF and 
      IPF% published in reports. For A-IPF, there was only one paired comparison with a 
      significant difference (Z > 1.96) across 6 reports. Thus, the contribution of the 
      factors examined on the RI of IPF cannot be determined. For IPF%, there were 8 
      paired comparisons with significant differences across 10 reports. The 
      discrepancy rates of RI for IPF% were 41.2%, 50.0%, and 25.0% with the difference 
      of reference individuals, the analyzer method, and ethnicity, respectively. 
      CONCLUSIONS: The RIs of Taiwanese for A-IPF and IPF% were established. 
      Furthermore, the analyzer detection method and the reference individuals 
      contribute to the discrepancy of the RI for IPF% and should be considered 
      cautiously when the value of IPF is interpreted.
FAU - Wu, Ming-Feng
AU  - Wu MF
FAU - Hsieh, Hsien-Hsu
AU  - Hsieh HH
FAU - Huang, Wei-Chang
AU  - Huang WC
FAU - Lu, Kun-Mu
AU  - Lu KM
FAU - Lin, Jun-Hong
AU  - Lin JH
FAU - Lin, Yi-Ching
AU  - Lin YC
FAU - Wang, Jiunn-Min
AU  - Wang JM
FAU - Lin, Tseng-Hsi
AU  - Lin TH
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Asian People
MH  - Biomarkers/*blood
MH  - Blood Platelets/*metabolism
MH  - Clinical Laboratory Techniques/instrumentation/methods
MH  - Female
MH  - Humans
MH  - Inflammation/*blood/ethnology
MH  - Male
MH  - Middle Aged
MH  - Platelet Count/*instrumentation/methods
MH  - Reference Values
MH  - Taiwan
MH  - *Thrombopoiesis
EDAT- 2018/05/09 06:00
MHDA- 2019/09/17 06:00
CRDT- 2018/05/09 06:00
PHST- 2018/05/09 06:00 [entrez]
PHST- 2018/05/09 06:00 [pubmed]
PHST- 2019/09/17 06:00 [medline]
AID - 10.7754/Clin.Lab.2018.171025 [doi]
PST - ppublish
SO  - Clin Lab. 2018 May 1;64(5):699-708. doi: 10.7754/Clin.Lab.2018.171025.