PMID- 29739040
OWN - NLM
STAT- MEDLINE
DCOM- 20190916
LR  - 20190916
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 64
IP  - 5
DP  - 2018 May 1
TI  - Serum Monocyte Chemoattractant Protein-1 Predicts Liver Inflammation of Patients 
      with Chronic Hepatitis B.
PG  - 841-846
LID - 10.7754/Clin.Lab.2017.171218 [doi]
AB  - BACKGROUND: The usefulness of serum markers for predicting liver 
      necroinflammation is limited in chronic hepatitis B (CHB) patients with normal or 
      slightly elevated alanine aminotransferase (ALT). Monocyte chemoattractant 
      protein-1 (MCP-1) is an important inflammatory mediator in liver disease. Our 
      study was to investigate the expression of MCP-1 and its diagnostic value in 
      patients with HBV-related liver necroinflammation. METHODS: One hundred and six 
      patients with hepatitis B virus (HBV) infection were recruited. All were positive 
      for hepatitis B e antigen (HBeAg) and underwent liver biopsy. Significant 
      inflammation was defined as inflammatory grade >/= 2 according to Scheuer's 
      classification scoring system. Enzyme-linked immunosorbent assay (ELISA) was used 
      to detect expression of MCP-1 in the peripheral blood of all patients, and 
      receiver operating characteristics (ROC) analysis was used to evaluate diagnostic 
      accuracy of MCP-1 and liver inflammation. RESULTS: MCP-1 level in patients with 
      HBV infection was higher than in healthy controls (p < 0.05). Moreover, MCP-1 
      level in the ALT >/= two times of upper limits of normal (2 ULN) group was higher 
      than that of the ALT < 2 ULN group (p < 0.05). In the ALT < 2 ULN group, the 
      MCP-1 level in patients whose inflammatory activity was grade >/= 2 was higher than 
      in patients with grade < 2 (p < 0.05). ROC curve analysis showed that the area 
      under the curve of MCP-1 in diagnosis of liver inflammation was 0.842. 
      CONCLUSIONS: MCP-1 could be used as a serological marker for non-invasive 
      evaluation of liver inflammation in CHB patients with normal or slightly elevated 
      ALT.
FAU - Fan, Yaoxin
AU  - Fan Y
FAU - Wang, Lin
AU  - Wang L
FAU - Dou, Xiaoguang
AU  - Dou X
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/*blood
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Hepatitis/*blood/complications/diagnosis
MH  - Hepatitis B virus/physiology
MH  - Hepatitis B, Chronic/*blood/complications/virology
MH  - Humans
MH  - Male
MH  - Prognosis
MH  - ROC Curve
MH  - Young Adult
EDAT- 2018/05/09 06:00
MHDA- 2019/09/17 06:00
CRDT- 2018/05/09 06:00
PHST- 2018/05/09 06:00 [entrez]
PHST- 2018/05/09 06:00 [pubmed]
PHST- 2019/09/17 06:00 [medline]
AID - 10.7754/Clin.Lab.2017.171218 [doi]
PST - ppublish
SO  - Clin Lab. 2018 May 1;64(5):841-846. doi: 10.7754/Clin.Lab.2017.171218.