PMID- 29740875
OWN - NLM
STAT- Publisher
LR  - 20240227
IS  - 1600-0560 (Electronic)
IS  - 0303-6987 (Linking)
DP  - 2018 May 8
TI  - Evaluation of epithelial dysplasia adjacent to lip squamous cell carcinoma 
      indicates that the degree of dysplasia is not associated with the occurrence of 
      invasive carcinoma in this site.
LID - 10.1111/cup.13270 [doi]
AB  - BACKGROUND: We analyzed the different grades of dysplasia in the epithelium 
      adjacent to lip squamous cell carcinoma (LSCC), as a parallel to actinic 
      cheilitis (AC) that suffered malignant transformation. METHODS: Forty samples of 
      epithelium adjacent to LSCC were histologically graded according to the World 
      Health Organization (WHO) and the binary systems. The expression of mutated p53 
      was evaluated through immunohistochemistry. RESULTS: According to WHO system, 
      37.5% of the cases were graded as mild, 45% as moderate and 17.5% as severe 
      dysplasia (P = 0.09). Considering the binary system, 90% of the cases were 
      classified as low-risk and 10% as high-risk lesions. Mutated p53 was present in 
      73.3% of mild, 88.8% of moderate and 71.4% of severe dysplasia cases. Considering 
      the binary system, 80.5% of the low-risk and 75% of high-risk lesions were 
      immunopositive; 62.5% expressed the protein in both tumor cells and adjacent 
      epithelium; 17.5% in adjacent epithelium only, and 7.5% in LSCC islands only 
      (P = 0.03). CONCLUSIONS: We observed heterogeneous grades of epithelial dysplasia 
      in the epithelium adjacent to LSCC, which indicates that the analysis of AC 
      morphological features is insufficient to predict patient's prognosis and to 
      determine a treatment decision. Positive expression of mutant p53 in mild 
      dysplasia reinforces this idea.
CI  - (c) 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Nagata, Gabriela
AU  - Nagata G
AD  - Department of Oral and Maxillofacial Pathology, School of Dentistry, University 
      of Sao Paulo - USP, Sao Paulo, Brazil.
FAU - Santana, Thalita
AU  - Santana T
AUID- ORCID: 0000-0002-2172-9031
AD  - Department of Oral and Maxillofacial Pathology, School of Dentistry, University 
      of Sao Paulo - USP, Sao Paulo, Brazil.
FAU - Queiroz, Aline
AU  - Queiroz A
AD  - Department of Oral and Maxillofacial Pathology, School of Dentistry, University 
      of Sao Paulo - USP, Sao Paulo, Brazil.
FAU - Caramez, Renata H
AU  - Caramez RH
AD  - Department of Oral and Maxillofacial Pathology, School of Dentistry, University 
      of Sao Paulo - USP, Sao Paulo, Brazil.
FAU - Trierveiler, Marilia
AU  - Trierveiler M
AUID- ORCID: 0000-0002-8517-2105
AD  - Department of Oral and Maxillofacial Pathology, School of Dentistry, University 
      of Sao Paulo - USP, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20180508
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
OTO - NOTNLM
OT  - actinic cheilitis
OT  - epithelial dysplasia
OT  - lip cancer
OT  - malignant transformation
OT  - mutant p53
EDAT- 2018/05/10 06:00
MHDA- 2018/05/10 06:00
CRDT- 2018/05/10 06:00
PHST- 2018/03/05 00:00 [received]
PHST- 2018/04/19 00:00 [revised]
PHST- 2018/05/04 00:00 [accepted]
PHST- 2018/05/10 06:00 [pubmed]
PHST- 2018/05/10 06:00 [medline]
PHST- 2018/05/10 06:00 [entrez]
AID - 10.1111/cup.13270 [doi]
PST - aheadofprint
SO  - J Cutan Pathol. 2018 May 8. doi: 10.1111/cup.13270.