PMID- 29741444
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200309
IS  - 1933-6926 (Electronic)
IS  - 1933-6918 (Print)
IS  - 1933-6918 (Linking)
VI  - 12
IP  - 5
DP  - 2018
TI  - Isoquercitrin, ingredients in Tetrastigma hemsleyanum Diels et Gilg, inhibits 
      hepatocyte growth factor/scatter factor-induced tumor cell migration and 
      invasion.
PG  - 464-471
LID - 10.1080/19336918.2018.1473664 [doi]
AB  - Aberrant activation of hepatocyte growth factor/scatter factor (HGF/SF) and its 
      receptor, Met, is involved in the development and progression of many human 
      cancers. In the screening assay of extracts from the root tuber of Tetrastigma 
      hemsleyanum Diels et Gilg, isoquercitrin inhibited HGF/SF-Met signaling as 
      indicated by its inhibitory activity on HGF/SF-induced cell scattering. Further 
      analysis revealed that isoquercitrin specifically inhibited HGF/SF-induced 
      tyrosine phosphorylation of Met. We also found that isoquercitrin decreased 
      HGF-induced migration and invasion by parental or HGF/SF-transfected bladder 
      carcinoma cell line NBT-II cells. Furthermore, isoquercitrin inhibited 
      HGF/SF-induced epithelial mesenchymal transition in vitro and the 
      invasion/metastasis of HGF/SF-transfected NBT-II cells in vivo. Our data suggest 
      the possible use of isoquercitrin in human cancers associated with dysregulated 
      HGF/SF-Met signaling.
FAU - Xia, Geng-Shou
AU  - Xia GS
AD  - a Department of Ecology , Lishui University , Lishui , Zhejiang , China.
FAU - Li, Shu-Hong
AU  - Li SH
AD  - b Department of Medicine and Health , Lishui University , Lishui , Zhejiang , 
      China.
FAU - Zhou, Wu
AU  - Zhou W
AUID- ORCID: 0000-0003-3105-8064
AUID- ORCID: 0000-0003-3105-8064
AD  - b Department of Medicine and Health , Lishui University , Lishui , Zhejiang , 
      China.
LA  - eng
PT  - Journal Article
DEP - 20180528
PL  - United States
TA  - Cell Adh Migr
JT  - Cell adhesion & migration
JID - 101469464
PMC - PMC6363047
OTO - NOTNLM
OT  - Diels et Gilg
OT  - Epithelial mesenchymal transition
OT  - Hepatocyte growth factor
OT  - Isoquercitrin
EDAT- 2018/05/10 06:00
MHDA- 2018/05/10 06:01
PMCR- 2019/05/28
CRDT- 2018/05/10 06:00
PHST- 2018/05/10 06:00 [pubmed]
PHST- 2018/05/10 06:01 [medline]
PHST- 2018/05/10 06:00 [entrez]
PHST- 2019/05/28 00:00 [pmc-release]
AID - 1473664 [pii]
AID - 10.1080/19336918.2018.1473664 [doi]
PST - ppublish
SO  - Cell Adh Migr. 2018;12(5):464-471. doi: 10.1080/19336918.2018.1473664. Epub 2018 
      May 28.