PMID- 29742620
OWN - NLM
STAT- MEDLINE
DCOM- 20190227
LR  - 20220410
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 29
IP  - 10
DP  - 2018 Jul 4
TI  - Ketamine differentially restores diverse alterations of neuroligins in brain 
      regions in a rat model of neuropathic pain-induced depression.
PG  - 863-869
LID - 10.1097/WNR.0000000000001045 [doi]
AB  - Depression is present in a large proportion of patients suffering from chronic 
      pain, and yet the underlying mechanisms remain to be elucidated. Neuroligins 
      (NLs), as a family of cell-adhesion proteins, are involved in synaptic formation 
      and have been linked to various neuropsychiatric disorders. Here, we studied the 
      alterations in NL1 and NL2 in the medial prefrontal cortex (mPFC), the anterior 
      cingulate cortex (ACC), and the hippocampus in a rat model of neuropathic 
      pain-induced depression, and whether ketamine, a rapid and robust antidepressant, 
      could restore these abnormalities. In the present study, we found that spared 
      nerve injury induced significant mechanical allodynia and subsequent 
      depressive-like symptoms, along with decreased NL1 and increased NL2 in the mPFC, 
      decreased NL1 in the ACC, and decreased NL2 in the hippocampus. In addition, 
      brain-derived neurotrophic factor (BDNF) was reduced in these brain regions. It 
      is noteworthy that ketamine (10 mg/kg) relieved neuropathic pain-induced 
      depressive behaviors and restored alterations of BDNF and NLs in the mPFC and the 
      hippocampus at 24 h and 72 h after the administration of ketamine, but only 
      restored BDNF in the ACC. In conclusion, NLs showed diverse changes in different 
      brain regions in the rat model of neuropathic pain-induced depression, which 
      could be reversed differentially by the administration of ketamine.
FAU - Pan, Wei
AU  - Pan W
AD  - Department of Anesthesiology, Jinling Hospital, Medical School of Nanjing 
      University.
FAU - Zhang, Guang-Fen
AU  - Zhang GF
AD  - Department of Anesthesiology, Zhongda Hospital, Medical School of Southeast 
      University, Nanjing, China.
FAU - Li, Hui-Hui
AU  - Li HH
AD  - Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing 
      University.
FAU - Ji, Mu-Huo
AU  - Ji MH
AD  - Department of Anesthesiology, Zhongda Hospital, Medical School of Southeast 
      University, Nanjing, China.
FAU - Zhou, Zhi-Qiang
AU  - Zhou ZQ
AD  - Department of Anesthesiology, Jinling Hospital, Medical School of Nanjing 
      University.
FAU - Li, Kuan-Yu
AU  - Li KY
AD  - Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing 
      University.
FAU - Yang, Jian-Jun
AU  - Yang JJ
AD  - Department of Anesthesiology, Jinling Hospital, Medical School of Nanjing 
      University.
AD  - Department of Anesthesiology, Zhongda Hospital, Medical School of Southeast 
      University, Nanjing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 690G0D6V8H (Ketamine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Behavior, Animal/*drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Depression/*drug therapy/metabolism
MH  - Disease Models, Animal
MH  - Gyrus Cinguli/drug effects/metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - Hyperalgesia/drug therapy/metabolism
MH  - Ketamine/*pharmacology
MH  - Male
MH  - Neuralgia/*drug therapy/metabolism
MH  - Prefrontal Cortex/drug effects/metabolism
MH  - Rats, Sprague-Dawley
PMC - PMC5999384
EDAT- 2018/05/10 06:00
MHDA- 2019/02/28 06:00
PMCR- 2018/06/13
CRDT- 2018/05/10 06:00
PHST- 2018/05/10 06:00 [pubmed]
PHST- 2019/02/28 06:00 [medline]
PHST- 2018/05/10 06:00 [entrez]
PHST- 2018/06/13 00:00 [pmc-release]
AID - 10.1097/WNR.0000000000001045 [doi]
PST - ppublish
SO  - Neuroreport. 2018 Jul 4;29(10):863-869. doi: 10.1097/WNR.0000000000001045.