PMID- 29742713
OWN - NLM
STAT- MEDLINE
DCOM- 20180516
LR  - 20210109
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 19
DP  - 2018 May
TI  - Flavonoids intake and risk of type 2 diabetes mellitus: A meta-analysis of 
      prospective cohort studies.
PG  - e0686
LID - 10.1097/MD.0000000000010686 [doi]
LID - e0686
AB  - Epidemiological studies exploring the role of flavonoids intake in preventing 
      type 2 diabetes mellitus (T2DM) showed inconsistent results. Therefore, we 
      performed a meta-analysis of relevant studies to examine the relationship between 
      flavonoids intake and risk of T2DM. We hypothesized that flavonoids intake may 
      decrease the risk of developing T2DM.A systematical search in PubMed and Embase 
      until September 2017 was performed to identify eligible prospective cohort 
      studies. The summary relative risks (RRs) and 95% confidence intervals (CIs) were 
      calculated using random-effect models. Dose-response pattern between total 
      flavonoids intake and T2DM risk was also estimated.Eight prospective studies were 
      included with 312,015 participants, of whom 19,953 developed T2DM during the 
      follow-up periods of 4 to 28 years. Compared with lower consumption, high intake 
      of total flavonoids was associated with a decreased risk of T2DM (RR: 0.89, 95% 
      CI: 0.82-0.96). Among flavonoid subclasses, inverse correlations with T2DM were 
      achieved for intakes of anthocyanidins, flavan-3-ols, flavonols, and isoflavones. 
      Dose-response meta-analysis indicated a curvilinear relationship between total 
      flavonoids intake and incident T2DM (P for nonlinearity = .042), with a 
      significant risk reduction at an intake of >/=550 mg/day. When assuming a linear 
      pattern, the risk of T2DM was decreased by 5% for each 300-mg/day increment in 
      total flavonoids intake (RR: 0.95, 95% CI: 0.93-0.97).Our study suggests that 
      higher intakes of total flavonoids and subclasses (anthocyanidins, flavan-3-ols, 
      flavonols, and isoflavones) are associated with lower risk of T2DM.
FAU - Xu, Hui
AU  - Xu H
AD  - Department of Endocrinology The Second Department of Oncology, The Central 
      Hospital of Enshi Autonomous Prefecture, Enshi, China.
FAU - Luo, Jia
AU  - Luo J
FAU - Huang, Jia
AU  - Huang J
FAU - Wen, Qian
AU  - Wen Q
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Flavonoids)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*prevention & control
MH  - *Diet
MH  - Dose-Response Relationship, Drug
MH  - Flavonoids/*administration & dosage
MH  - Humans
MH  - Middle Aged
MH  - Risk Factors
PMC - PMC5959406
COIS- The authors report no conflicts of interest.
EDAT- 2018/05/10 06:00
MHDA- 2018/05/17 06:00
PMCR- 2018/05/11
CRDT- 2018/05/10 06:00
PHST- 2018/05/10 06:00 [entrez]
PHST- 2018/05/10 06:00 [pubmed]
PHST- 2018/05/17 06:00 [medline]
PHST- 2018/05/11 00:00 [pmc-release]
AID - 00005792-201805110-00032 [pii]
AID - MD-D-17-07498 [pii]
AID - 10.1097/MD.0000000000010686 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2018 May;97(19):e0686. doi: 10.1097/MD.0000000000010686.