PMID- 29743139
OWN - NLM
STAT- MEDLINE
DCOM- 20190520
LR  - 20190520
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 201
DP  - 2018 Nov
TI  - The relationship between the level of exposure to stress factors and cannabis in 
      recent onset psychosis.
PG  - 352-359
LID - S0920-9964(18)30255-X [pii]
LID - 10.1016/j.schres.2018.04.040 [doi]
AB  - BACKGROUND: There is a lack of studies investigating the dose-response effect of 
      childhood trauma, recent events and cannabis use on recent psychosis. This study 
      aims to determine the relationship between the level of exposure to stress 
      factors and cannabis use with psychosis and to determine the combination effect 
      among these factors in predicting a psychotic disorder. METHODS: 146 recent onset 
      psychotic (ROP) patients and 61 healthy controls were included. Childhood trauma 
      was evaluated using the childhood trauma questionnaire (CTQ) and recent events 
      using the Holmes-Rahe social readjustment scale. The pattern of cannabis use was 
      assessed by a detailed interview. A hierarchical multiple regression was run in 
      order to determine both the cumulative and independent contribution of each 
      factor in predicting a psychotic disorder. RESULTS: The highest levels of 
      exposure to childhood trauma and cannabis were associated with psychosis while 
      neither low nor high recent event exposure was associated. The combined effect of 
      risk factors yielded a significant association with psychosis (x(2) = 86.76, 
      p < .001) explaining the 49% of its variation. ROP were more likely to be exposed 
      to one, two or three environmental factors than HC. Exposed to two or all factors 
      were 7.5-fold and 26.7-fold more likely to have a diagnosis of psychosis, 
      respectively. CONCLUSIONS: Our study provides evidence for a cumulative and a 
      dose-response effect of environmental factors on recent psychosis. Considering 
      that cannabis use and stress are highly prevalent in the population with 
      psychosis, investigations of their relationships are needed to implement targeted 
      prevention and treatment strategies.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Arranz, Sara
AU  - Arranz S
AD  - Hospital Universitari Institut Pere Mata of Reus, IISPV, Universitat Rovira 
      Virgili and CIBERSAM, Spain. Electronic address: arranzs@peremata.com.
FAU - Monferrer, Nuria
AU  - Monferrer N
AD  - Hospital Universitari Institut Pere Mata of Reus, IISPV, Universitat Rovira 
      Virgili and CIBERSAM, Spain. Electronic address: monferrern@peremata.com.
FAU - Jose Algora, M
AU  - Jose Algora M
AD  - Hospital Universitari Institut Pere Mata of Reus, IISPV, Universitat Rovira 
      Virgili and CIBERSAM, Spain. Electronic address: algoram@peremata.com.
FAU - Cabezas, Angel
AU  - Cabezas A
AD  - Hospital Universitari Institut Pere Mata of Reus, IISPV, Universitat Rovira 
      Virgili and CIBERSAM, Spain. Electronic address: cabezas@peremata.com.
FAU - Sole, Montse
AU  - Sole M
AD  - Hospital Universitari Institut Pere Mata of Reus, IISPV, Universitat Rovira 
      Virgili and CIBERSAM, Spain. Electronic address: solem@peremata.com.
FAU - Vilella, E
AU  - Vilella E
AD  - Hospital Universitari Institut Pere Mata of Reus, IISPV, Universitat Rovira 
      Virgili and CIBERSAM, Spain.
FAU - Labad, J
AU  - Labad J
AD  - Department of Mental Health, Parc Tauli Hospital Universitari, Institut 
      d'Investigacio Sanitaria Parc Tauli (I3PT), Universitat Autonoma de Barcelona, 
      CIBERSAM, Sabadell, Spain.
FAU - Sanchez-Gistau, Vanessa
AU  - Sanchez-Gistau V
AD  - Hospital Universitari Institut Pere Mata of Reus, IISPV, Universitat Rovira 
      Virgili and CIBERSAM, Spain. Electronic address: sanchezv@peremata.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180506
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Adult Survivors of Child Abuse
MH  - Cannabis
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Marijuana Abuse/epidemiology
MH  - Marijuana Use/*epidemiology
MH  - Psychotic Disorders/*epidemiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Stress, Psychological/*epidemiology
MH  - Young Adult
OTO - NOTNLM
OT  - Cannabis
OT  - Psychosis
OT  - Stress
EDAT- 2018/05/11 06:00
MHDA- 2019/05/21 06:00
CRDT- 2018/05/11 06:00
PHST- 2018/01/12 00:00 [received]
PHST- 2018/04/27 00:00 [revised]
PHST- 2018/04/29 00:00 [accepted]
PHST- 2018/05/11 06:00 [pubmed]
PHST- 2019/05/21 06:00 [medline]
PHST- 2018/05/11 06:00 [entrez]
AID - S0920-9964(18)30255-X [pii]
AID - 10.1016/j.schres.2018.04.040 [doi]
PST - ppublish
SO  - Schizophr Res. 2018 Nov;201:352-359. doi: 10.1016/j.schres.2018.04.040. Epub 2018 
      May 6.