PMID- 29743648
OWN - NLM
STAT- MEDLINE
DCOM- 20191017
LR  - 20220409
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 May 9
TI  - A TPMS-based method for modeling porous scaffolds for bionic bone tissue 
      engineering.
PG  - 7395
LID - 10.1038/s41598-018-25750-9 [doi]
LID - 7395
AB  - In the field of bone defect repair, gradient porous scaffolds have received 
      increased attention because they provide a better environment for promoting 
      tissue regeneration. In this study, we propose an effective method to generate 
      bionic porous scaffolds based on the TPMS (triply periodic minimal surface) and 
      SF (sigmoid function) methods. First, cortical bone morphological features (e.g., 
      pore size and distribution) were determined for several regions of a rabbit 
      femoral bone by analyzing CT-scans. A finite element method was used to evaluate 
      the mechanical properties of the bone at these respective areas. These results 
      were used to place different TPMS substructures into one scaffold domain with 
      smooth transitions. The geometrical parameters of the scaffolds were optimized to 
      match the elastic properties of a human bone. With this proposed method, a 
      functional gradient porous scaffold could be designed and produced by an additive 
      manufacturing method.
FAU - Shi, Jianping
AU  - Shi J
AD  - School of Mechanical Engineering, Southeast University, Nanjing, 211189, China.
AD  - Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, Nanjing Normal 
      University, Nanjing, 210042, China.
FAU - Zhu, Liya
AU  - Zhu L
AD  - Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, Nanjing Normal 
      University, Nanjing, 210042, China.
FAU - Li, Lan
AU  - Li L
AD  - School of Mechanical Engineering, Southeast University, Nanjing, 211189, China.
AD  - Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower 
      Hospital affiliated to Medical School of Nanjing University, Nanjing, China.
FAU - Li, Zongan
AU  - Li Z
AD  - School of Mechanical Engineering, Southeast University, Nanjing, 211189, China.
FAU - Yang, Jiquan
AU  - Yang J
AD  - Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, Nanjing Normal 
      University, Nanjing, 210042, China. 61047@njnu.edu.cn.
FAU - Wang, Xingsong
AU  - Wang X
AD  - School of Mechanical Engineering, Southeast University, Nanjing, 211189, China. 
      xswang007@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180509
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Animals
MH  - *Bionics
MH  - Bone and Bones/*diagnostic imaging
MH  - Humans
MH  - Male
MH  - Porosity
MH  - Rabbits
MH  - Tissue Engineering/*methods
PMC - PMC5943328
COIS- The authors declare no competing interests.
EDAT- 2018/05/11 06:00
MHDA- 2019/10/18 06:00
PMCR- 2018/05/09
CRDT- 2018/05/11 06:00
PHST- 2017/11/09 00:00 [received]
PHST- 2018/04/27 00:00 [accepted]
PHST- 2018/05/11 06:00 [entrez]
PHST- 2018/05/11 06:00 [pubmed]
PHST- 2019/10/18 06:00 [medline]
PHST- 2018/05/09 00:00 [pmc-release]
AID - 10.1038/s41598-018-25750-9 [pii]
AID - 25750 [pii]
AID - 10.1038/s41598-018-25750-9 [doi]
PST - epublish
SO  - Sci Rep. 2018 May 9;8(1):7395. doi: 10.1038/s41598-018-25750-9.