PMID- 29743840
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220317
IS  - 1598-9100 (Print)
IS  - 2288-1956 (Electronic)
IS  - 1598-9100 (Linking)
VI  - 16
IP  - 2
DP  - 2018 Apr
TI  - Evaluation of the drug-induced lymphocyte stimulation test for diagnosing 
      mesalazine allergy.
PG  - 273-281
LID - 10.5217/ir.2018.16.2.273 [doi]
AB  - BACKGROUND/AIMS: Mesalazine is an effective drug for treating ulcerative colitis 
      (UC), but causes allergic symptoms in a few cases. Therefore, the objective of 
      this study was to evaluate the usefulness of the drug-induced lymphocyte 
      stimulation test (DLST) for the diagnosis of mesalazine allergy. METHODS: 
      Patients with UC treated with mesalazine with or without a history of associated 
      adverse events (AEs) were enrolled at Kyorin University Hospital from July 2016 
      to April 2017. RESULTS: The DLST was performed in 104 patients with UC, of which 
      24 had a history of AEs due to mesalazine treatment. The control value of DLST 
      was 337.4+/-296.3 counts per minute (cpm) in the AE(+) group and 408.0+/-371.9 cpm in 
      the AE(-) group. The measured value of DLST was 578.8+/-424.7 cpm in the AE(+) 
      group and 476.5+/-471.8 cpm in the AE(-) group. The stimulation index (SI) was 
      243.9%+/-291.1% in the AE(+) group and 119.8%+/-53.0% in the AE(-) group. The SI 
      value and DLST positivity were significantly higher in the AE(+) group than in 
      the AE(-) group (P=0.030 and P=0.029, respectively). The test sensitivity and 
      specificity were 0.240 and 0.805, respectively, and the false-positive and 
      false-negative rate was 0.195 and 0.760, respectively. CONCLUSIONS: The DLST for 
      mesalazine showed low sensitivity and high specificity, suggesting that it may be 
      useful for the definitive diagnosis of allergy to mesalazine.
FAU - Saito, Daisuke
AU  - Saito D
AD  - The Third Department of Internal Medicine, Kyorin University School of Medicine, 
      Mitaka, Japan.
FAU - Hayashida, Mari
AU  - Hayashida M
AD  - The Third Department of Internal Medicine, Kyorin University School of Medicine, 
      Mitaka, Japan.
FAU - Sato, Taro
AU  - Sato T
AD  - The Third Department of Internal Medicine, Kyorin University School of Medicine, 
      Mitaka, Japan.
FAU - Minowa, Shintaro
AU  - Minowa S
AD  - The Third Department of Internal Medicine, Kyorin University School of Medicine, 
      Mitaka, Japan.
FAU - Ikezaki, Osamu
AU  - Ikezaki O
AD  - The Third Department of Internal Medicine, Kyorin University School of Medicine, 
      Mitaka, Japan.
FAU - Mitsui, Tatsuya
AU  - Mitsui T
AD  - The Third Department of Internal Medicine, Kyorin University School of Medicine, 
      Mitaka, Japan.
FAU - Miura, Miki
AU  - Miura M
AD  - The Third Department of Internal Medicine, Kyorin University School of Medicine, 
      Mitaka, Japan.
FAU - Sakuraba, Akihito
AU  - Sakuraba A
AD  - The Third Department of Internal Medicine, Kyorin University School of Medicine, 
      Mitaka, Japan.
FAU - Hisamatsu, Tadakazu
AU  - Hisamatsu T
AD  - The Third Department of Internal Medicine, Kyorin University School of Medicine, 
      Mitaka, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180430
PL  - Korea (South)
TA  - Intest Res
JT  - Intestinal research
JID - 101572802
PMC - PMC5934600
OTO - NOTNLM
OT  - Colitis, ulcerative
OT  - Drug-induced lymphocyte stimulation test
OT  - Mesalamine
COIS- CONFLICT OF INTEREST: No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2018/05/11 06:00
MHDA- 2018/05/11 06:01
PMCR- 2018/04/01
CRDT- 2018/05/11 06:00
PHST- 2017/08/11 00:00 [received]
PHST- 2017/10/07 00:00 [revised]
PHST- 2017/10/08 00:00 [accepted]
PHST- 2018/05/11 06:00 [entrez]
PHST- 2018/05/11 06:00 [pubmed]
PHST- 2018/05/11 06:01 [medline]
PHST- 2018/04/01 00:00 [pmc-release]
AID - 10.5217/ir.2018.16.2.273 [doi]
PST - ppublish
SO  - Intest Res. 2018 Apr;16(2):273-281. doi: 10.5217/ir.2018.16.2.273. Epub 2018 Apr 
      30.