PMID- 29744249
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220317
IS  - 2667-677X (Print)
IS  - 2149-276X (Electronic)
IS  - 2149-276X (Linking)
VI  - 46
IP  - 2
DP  - 2018 Apr
TI  - The Effect of Anaesthetic Techniques on Maternal and Cord Blood Brain-Derived 
      Neurotrophic Factor Levels.
PG  - 139-146
LID - 10.5152/TJAR.2018.90187 [doi]
AB  - OBJECTIVE: Brain-derived neurotrophic factor (BDNF), a member of neurotrophins, 
      plays a critical role in neuronal tissue. In this study, the effects of spinal or 
      general anaesthesia on cord and maternal peripheral blood BDNF and 
      malondialdehyde (MDA) levels were investigated in patients undergoing elective 
      caesarean section. METHODS: Eighty patients with term pregnancy were included. 
      General anaesthesia was induced with intravenous (IV) propofol 2 mg kg(-1) in the 
      general anaesthesia group (n=36). In the spinal anaesthesia group (n=35), 
      hyperbaric bupivacaine 0.5%, 9 mg (1.8 mL) was injected intrathecally. Maternal 
      blood samples were taken immediately after positioning the patient on the 
      operating table (T1), before clamping the umbilical cord (T2) and 24 hours after 
      the first sample was obtained (T3). Cord blood samples were drawn from the 
      umbilical artery (T4). RESULTS: Maternal BDNF levels (pg mL(-1)) measured at T2 
      time point were higher in the general anaesthesia group compared to the spinal 
      anaesthesia group (p<0.001). Cord blood BDNF levels were higher in the general 
      anaesthesia group compared to the spinal anaesthesia group (p<0.001). In both 
      groups, cord blood BDNF levels were significantly lower compared to the maternal 
      blood samples collected at any time point (p<0.001, for all). There was a 
      negative association between both maternal and cord blood BDNF levels with 
      maternal MDA and cord blood MDA levels, respectively (r=-0.379, p<0.001; 
      r=-0.375, p=0.001, respectively). CONCLUSION: The anaesthetic technique may have 
      an influence on maternal peripheral and cord blood BDNF levels.
FAU - Aksoy, Mehmet
AU  - Aksoy M
AUID- ORCID: 0000-0003-0867-8660
AD  - Department of Anesthesiology and Reanimation, Ataturk University School of 
      Medicine, Erzurum, Turkey.
FAU - Aksoy, Ayse Nur
AU  - Aksoy AN
AUID- ORCID: 0000-0002-3793-9797
AD  - Clinic of Obstetrics and Gynecology, Nenehatun Hospital, Erzurum, Turkey.
FAU - Ahiskalioglu, Ali
AU  - Ahiskalioglu A
AUID- ORCID: 0000-0002-8467-8171
AD  - Department of Anesthesiology and Reanimation, Ataturk University School of 
      Medicine, Erzurum, Turkey.
FAU - Ince, Ilker
AU  - Ince I
AUID- ORCID: 0000-0003-1791-9884
AD  - Department of Anesthesiology and Reanimation, Ataturk University School of 
      Medicine, Erzurum, Turkey.
FAU - Laloglu, Esra
AU  - Laloglu E
AUID- ORCID: 0000-0001-5189-3564
AD  - Department of Biochemistry, Ataturk University School of Medicine, Erzurum, 
      Turkey.
FAU - Dostbil, Aysenur
AU  - Dostbil A
AUID- ORCID: 0000-0002-7167-901X
AD  - Department of Anesthesiology and Reanimation, Ataturk University School of 
      Medicine, Erzurum, Turkey.
FAU - Celik, Mine Gursac
AU  - Celik MG
AUID- ORCID: 0000-0002-4718-0921
AD  - Department of Anesthesiology and Reanimation, Ataturk University School of 
      Medicine, Erzurum, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20180301
PL  - Turkey
TA  - Turk J Anaesthesiol Reanim
JT  - Turkish journal of anaesthesiology and reanimation
JID - 101680817
PMC - PMC5937460
OTO - NOTNLM
OT  - Anaesthetic technique
OT  - brain-derived neurotrophic factor
OT  - cord blood
OT  - maternal peripheral blood
COIS- Conflict of Interest: No conflict of interest was declared by the authors.
EDAT- 2018/05/11 06:00
MHDA- 2018/05/11 06:01
PMCR- 2018/04/01
CRDT- 2018/05/11 06:00
PHST- 2016/04/10 00:00 [received]
PHST- 2017/11/22 00:00 [accepted]
PHST- 2018/05/11 06:00 [entrez]
PHST- 2018/05/11 06:00 [pubmed]
PHST- 2018/05/11 06:01 [medline]
PHST- 2018/04/01 00:00 [pmc-release]
AID - tard-46-1-139 [pii]
AID - 10.5152/TJAR.2018.90187 [doi]
PST - ppublish
SO  - Turk J Anaesthesiol Reanim. 2018 Apr;46(2):139-146. doi: 10.5152/TJAR.2018.90187. 
      Epub 2018 Mar 1.