PMID- 29744362
OWN - NLM
STAT- MEDLINE
DCOM- 20180921
LR  - 20181114
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2018
DP  - 2018
TI  - Antioxidant, Hepatoprotective, and Antidepression Effects of Rumex tingitanus 
      Extracts and Identification of a Novel Bioactive Compound.
PG  - 7295848
LID - 10.1155/2018/7295848 [doi]
LID - 7295848
AB  - Over the last few decades, Rumex species have been recognized as a promising 
      source of new compounds with numerous pharmacological activities. Therefore, the 
      antioxidant activity of Rumex tingitanus (R. tingitanus) leaves extracts was 
      evaluated in vitro and then confirmed in vivo as well as the antidepressant-like 
      and toxicological effects of the extracts. The ethyl acetate fraction (Rt EtOAcF) 
      followed by hydroalcoholic extract (Rt EtOH-H(2)O) showed a remarkable in vitro 
      antioxidant activity. The hydroalcoholic extract (Rt EtOH-H(2)O) showed 
      significant hepatoprotective activity against carbon tetrachloride- (CCl(4)-) 
      induced liver toxicity which is seen from inhibition of the malondialdehyde (MDA) 
      accumulation and enhancement of the liver antioxidant enzymes activities. The Rt 
      EtOH-H(2)O and Rt EtOAcF extracts were able to reduce the immobility time in mice 
      and then elicited a significant antidepressant-like effect. The ethyl acetate 
      fraction (Rt EtOAcF) was purified and resulted in the identification of a new 
      antioxidant component called 4'-p-acetylcoumaroyl luteolin. The Rt EtOAcF and the 
      4'-p-acetylcoumaroyl luteolin revealed a strong antioxidant activity using DPPH 
      test with IC(50) of 11.7 +/- 0.2 and 20.74 +/- 0.6 mug/ml, respectively, and AAI of 
      3.39 and 1.92 better than that of BHT, used as control.
FAU - Mhalla, Dhekra
AU  - Mhalla D
AD  - Biopesticides Laboratory, Center of Biotechnology of Sfax, University of Sfax, 
      P.O. Box 1177, 3018 Sfax, Tunisia.
FAU - Zouari Bouassida, Karama
AU  - Zouari Bouassida K
AUID- ORCID: 0000-0002-3036-6877
AD  - Biopesticides Laboratory, Center of Biotechnology of Sfax, University of Sfax, 
      P.O. Box 1177, 3018 Sfax, Tunisia.
FAU - Chawech, Rachid
AU  - Chawech R
AD  - Laboratory of Chemistry of Natural Products, Faculty of Sciences of Sfax, P.O. 
      Box 1171, 3000 Sfax, Tunisia.
FAU - Bouaziz, Amira
AU  - Bouaziz A
AD  - Laboratory of Chemistry of Natural Products, Faculty of Sciences of Sfax, P.O. 
      Box 1171, 3000 Sfax, Tunisia.
FAU - Makni, Samar
AU  - Makni S
AD  - Biopesticides Laboratory, Center of Biotechnology of Sfax, University of Sfax, 
      P.O. Box 1177, 3018 Sfax, Tunisia.
FAU - Jlaiel, Lobna
AU  - Jlaiel L
AD  - Analysis Service of the Center of Biotechnology of Sfax, University of Sfax, P.O. 
      Box 1177, 3018 Sfax, Tunisia.
FAU - Tounsi, Slim
AU  - Tounsi S
AUID- ORCID: 0000-0002-1545-0122
AD  - Biopesticides Laboratory, Center of Biotechnology of Sfax, University of Sfax, 
      P.O. Box 1177, 3018 Sfax, Tunisia.
FAU - Mezghani Jarraya, Raoudha
AU  - Mezghani Jarraya R
AD  - Laboratory of Chemistry of Natural Products, Faculty of Sciences of Sfax, P.O. 
      Box 1171, 3000 Sfax, Tunisia.
FAU - Trigui, Mohamed
AU  - Trigui M
AUID- ORCID: 0000-0002-3297-0293
AD  - Biopesticides Laboratory, Center of Biotechnology of Sfax, University of Sfax, 
      P.O. Box 1177, 3018 Sfax, Tunisia.
AD  - Research Unit "Coastal and Urban Environments", Sfax Preparatory Engineering 
      Institute, University of Sfax, BP 1172, 3018 Sfax, Tunisia.
LA  - eng
PT  - Journal Article
DEP - 20180318
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Antidepressive Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Plant Extracts)
RN  - CL2T97X0V0 (Carbon Tetrachloride)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/administration & dosage/chemistry
MH  - Antioxidants/*administration & dosage/chemistry
MH  - Carbon Tetrachloride/toxicity
MH  - Chemical and Drug Induced Liver Injury/*drug therapy/pathology
MH  - Humans
MH  - Mice
MH  - Phytotherapy
MH  - Plant Extracts/*administration & dosage/chemistry
MH  - Plant Leaves/chemistry
MH  - Rumex/*chemistry
PMC - PMC5878904
EDAT- 2018/05/11 06:00
MHDA- 2018/09/22 06:00
PMCR- 2018/03/18
CRDT- 2018/05/11 06:00
PHST- 2017/11/01 00:00 [received]
PHST- 2018/01/18 00:00 [revised]
PHST- 2018/02/14 00:00 [accepted]
PHST- 2018/05/11 06:00 [entrez]
PHST- 2018/05/11 06:00 [pubmed]
PHST- 2018/09/22 06:00 [medline]
PHST- 2018/03/18 00:00 [pmc-release]
AID - 10.1155/2018/7295848 [doi]
PST - epublish
SO  - Biomed Res Int. 2018 Mar 18;2018:7295848. doi: 10.1155/2018/7295848. eCollection 
      2018.