PMID- 29746771 OWN - NLM STAT- MEDLINE DCOM- 20180611 LR - 20180611 IS - 1520-5118 (Electronic) IS - 0021-8561 (Linking) VI - 66 IP - 21 DP - 2018 May 30 TI - New Antimicrobial Cyclopentenones from Nigrospora sphaerica ZMT05, a Fungus Derived from Oxya chinensis Thunber. PG - 5368-5372 LID - 10.1021/acs.jafc.8b01376 [doi] AB - Six new cyclopentenone derivatives (+)-nigrosporione A (+)-1, (-)-nigrosporione A (-)-1, nigrosporione B (2), nigrosporione C (3), (+)-nigrosporione D (+)-4, and (-)-nigrosporione D (-)-4 were isolated from an endophytic fungus Nigrospora sphaerica ZMT05, collected from the rice grasshopper ( Oxya chinensis Thunberg), which is an insect pest in rice and which is also used as a food for people in some countries. Their planar and spatial structures were determined by spectroscopic analyses and eletronic circular dichroism (ECD) calculations. Compounds (+)-1, (-)-1, and 2 inhibited the plant pathogens Fusarium oxysporum, Colletotrichum musae, Penicillium italicum, and Fusarium graminearum, compounds 3 and (-)-4 inhibited F. oxysporum, C. musae, and P. italicum, and compound (+)-4 inhibited F. oxysporum, C. musae, and F. graminearum, showing antifungal activities stronger than triadimefon. Additionally, compounds (+)-1, (-)-1, 2, and 3 displayed moderate antibacterial activities against Staphyloccocus aureus and Escherichia coli. FAU - Wu, Zhihui AU - Wu Z AD - College of Materials and Energy , South China Agricultural University , Guangzhou 510642 , China. FAU - Xie, Zihui AU - Xie Z AD - College of Materials and Energy , South China Agricultural University , Guangzhou 510642 , China. FAU - Wu, Manlin AU - Wu M AD - College of Materials and Energy , South China Agricultural University , Guangzhou 510642 , China. FAU - Li, Xiaoqi AU - Li X AD - College of Materials and Energy , South China Agricultural University , Guangzhou 510642 , China. FAU - Li, Weilin AU - Li W AD - College of Materials and Energy , South China Agricultural University , Guangzhou 510642 , China. FAU - Ding, Weijia AU - Ding W AD - College of Materials and Energy , South China Agricultural University , Guangzhou 510642 , China. FAU - She, Zhigang AU - She Z AD - School of Chemistry and Chemical Engineering , Sun Yat-sen University , Guangzhou 510275 , China. FAU - Li, Chunyuan AU - Li C AUID- ORCID: 0000-0001-8817-8994 AD - College of Materials and Energy , South China Agricultural University , Guangzhou 510642 , China. LA - eng PT - Journal Article DEP - 20180518 PL - United States TA - J Agric Food Chem JT - Journal of agricultural and food chemistry JID - 0374755 RN - 0 (Anti-Infective Agents) RN - 0 (Antifungal Agents) RN - 0 (Cyclopentanes) RN - Q0U2IGF9CK (cyclopentenone) SB - IM MH - Animals MH - Anti-Infective Agents/*chemistry/isolation & purification/pharmacology MH - Antifungal Agents/chemistry/isolation & purification/pharmacology MH - Ascomycota/*chemistry MH - Cyclopentanes/*chemistry MH - Escherichia coli/drug effects MH - Grasshoppers/*microbiology MH - Staphylococcus aureus/drug effects OTO - NOTNLM OT - Nigrospora sphaerica OT - Oxya chinensis Thunberg OT - antifungal activity OT - cyclopentenone OT - insect-derived fungi EDAT- 2018/05/11 06:00 MHDA- 2018/06/12 06:00 CRDT- 2018/05/11 06:00 PHST- 2018/05/11 06:00 [pubmed] PHST- 2018/06/12 06:00 [medline] PHST- 2018/05/11 06:00 [entrez] AID - 10.1021/acs.jafc.8b01376 [doi] PST - ppublish SO - J Agric Food Chem. 2018 May 30;66(21):5368-5372. doi: 10.1021/acs.jafc.8b01376. Epub 2018 May 18.