PMID- 29746789
OWN - NLM
STAT- MEDLINE
DCOM- 20190318
LR  - 20190610
IS  - 1715-5320 (Electronic)
IS  - 1715-5312 (Linking)
VI  - 43
IP  - 12
DP  - 2018 Dec
TI  - Effect of carbohydrate restriction-induced weight loss on aortic pulse wave 
      velocity in overweight men and women.
PG  - 1247-1256
LID - 10.1139/apnm-2018-0113 [doi]
AB  - Increased aortic stiffness, measured by carotid-to-femoral pulse wave velocity 
      (PWV), is an independent predictor of cardiovascular disease, and past data have 
      shown that low-fat and low-energy diets, fed for 8-24 weeks, lower PWV. The 
      purpose of this study was to determine whether a reduction in PWV would be 
      achieved by dietary carbohydrate (CHO) restriction, shown to bring about weight 
      loss over a shorter timeframe. Men (n = 10, age: 41.8 +/- 10.2 years, BMI: 34.2 +/- 
      3.0 kg/m(2) (mean +/- SD)) and women (n = 10, age: 38.6 +/- 6.1 years, BMI: 33.5 +/- 
      3.8 kg/m(2)) with characteristics of insulin resistance and the metabolic 
      syndrome consumed a structured, CHO-restricted diet for 4 weeks (energy deficit, 
      645 kcal/day). For the whole group, subjects lost 5.4% +/- 0.5% (P < 0.001) of body 
      weight and experienced significant reductions in blood pressure (6%-8%), plasma 
      insulin (34%), and triglycerides (34%). PWV was reduced by 6% +/- 2% (7.1 +/- 0.2 m/s 
      to 6.7 +/- 0.2 m/s, P = 0.008) and surprisingly, in women, it fell significantly 
      (from 7.2 +/- 0.3 m/s to 6.3 +/- 0.3 m/s, P = 0.028), while no changes were observed 
      in men (7.2 +/- 0.3 vs. 7.0 +/- 0.3 m/s, P = 0.144). This is the first study to 
      demonstrate that weight loss can improve PWV in as little as 4 weeks and that 
      dietary CHO restriction may be an effective treatment for reducing aortic 
      stiffness in women. Future studies are needed to establish the mechanisms by 
      which dietary CHO restriction may confer more cardiovascular benefits to women 
      than to men.
FAU - Syed-Abdul, Majid M
AU  - Syed-Abdul MM
AD  - a Department of Nutrition and Exercise Physiology, University of Missouri, 
      Columbia, MO 65211, USA.
FAU - Hu, Qiong
AU  - Hu Q
AD  - a Department of Nutrition and Exercise Physiology, University of Missouri, 
      Columbia, MO 65211, USA.
FAU - Jacome-Sosa, Miriam
AU  - Jacome-Sosa M
AD  - a Department of Nutrition and Exercise Physiology, University of Missouri, 
      Columbia, MO 65211, USA.
FAU - Padilla, Jaume
AU  - Padilla J
AD  - a Department of Nutrition and Exercise Physiology, University of Missouri, 
      Columbia, MO 65211, USA.
AD  - b Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 
      65211, USA.
AD  - c Department of Child Health, School of Medicine, University of Missouri, 
      Columbia, MO 65212, USA.
FAU - Manrique-Acevedo, Camila
AU  - Manrique-Acevedo C
AD  - d Division of Endocrinology, School of Medicine, University of Missouri, 
      Columbia, MO 65212, USA.
FAU - Heimowitz, Colette
AU  - Heimowitz C
AD  - e Atkins Nutritionals, Inc., Denver, CO 80202, USA.
FAU - Parks, Elizabeth J
AU  - Parks EJ
AD  - a Department of Nutrition and Exercise Physiology, University of Missouri, 
      Columbia, MO 65211, USA.
AD  - c Department of Child Health, School of Medicine, University of Missouri, 
      Columbia, MO 65212, USA.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20180510
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
RN  - 0 (Dietary Carbohydrates)
SB  - IM
MH  - Adult
MH  - Aorta/*physiology
MH  - *Diet, Carbohydrate-Restricted
MH  - Dietary Carbohydrates
MH  - Eating
MH  - Female
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - Male
MH  - Middle Aged
MH  - *Overweight/diet therapy/epidemiology/physiopathology
MH  - *Pulse Wave Analysis
MH  - Weight Loss/*physiology
OTO - NOTNLM
OT  - carbohydrate metabolism
OT  - insulin resistance
OT  - insulinoresistance
OT  - metabolism
OT  - metabolisme
OT  - metabolisme des sucres
OT  - perte de poids
OT  - pulse wave velocity
OT  - vitesse de l'onde de pouls
OT  - weight loss
EDAT- 2018/05/11 06:00
MHDA- 2019/03/19 06:00
CRDT- 2018/05/11 06:00
PHST- 2018/05/11 06:00 [pubmed]
PHST- 2019/03/19 06:00 [medline]
PHST- 2018/05/11 06:00 [entrez]
AID - 10.1139/apnm-2018-0113 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2018 Dec;43(12):1247-1256. doi: 10.1139/apnm-2018-0113. 
      Epub 2018 May 10.