PMID- 29748879
OWN - NLM
STAT- MEDLINE
DCOM- 20181010
LR  - 20240109
IS  - 1573-4838 (Electronic)
IS  - 0957-4530 (Linking)
VI  - 29
IP  - 5
DP  - 2018 May 10
TI  - Poly-L-ornithine/fucoidan-coated calcium carbonate microparticles by 
      layer-by-layer self-assembly technique for cancer theranostics.
PG  - 68
LID - 10.1007/s10856-018-6075-z [doi]
AB  - Recently, the layer-by-layer (LbL) self-assembly technology has attracted the 
      enormous interest of researchers in synthesizing various pharmaceutical dosage 
      forms. Herewith, we designed a biocompatible drug delivery system containing the 
      calcium carbonate microparticles (CaCO(3) MPs) that coated with the alternatively 
      charged polyelectrolytes, i.e., poly-L-ornithine (PLO)/fucoidan by LbL 
      self-assembly process (LbL MPs). Upon coating with the polyelectrolytes, the mean 
      particle size of MPs obtained from SEM observations increased from 1.91 to 
      2.03 mum, and the surface of LbL MPs was smoothened compared to naked CaCO(3) MPs. 
      In addition, the reversible zeta potential changes have confirmed the 
      accomplishment of layer upon a layer assembly. To evaluate the efficiency of 
      cancer therapeutics, we loaded doxorubicin (Dox) in the LbL MPs, which resulted 
      in high (69.7%) drug encapsulation efficiency. The controlled release of Dox 
      resulted in the significant antiproliferative efficiency in breast cancer cell 
      line (MCF-7 cells), demonstrating the potential of applying this innovative drug 
      delivery system in the biomedical field.
FAU - Wang, Pei
AU  - Wang P
AD  - College of Chemical Engineering, Huaqiao University, Xiamen, 361021, China.
AD  - College of Materials Science and Engineering, Huaqiao University, Xiamen, 361021, 
      China.
FAU - Kankala, Ranjith Kumar
AU  - Kankala RK
AD  - College of Chemical Engineering, Huaqiao University, Xiamen, 361021, China.
AD  - Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen, 361021, 
      China.
AD  - Fujian Provincial Key Laboratory of Biochemical Technology, Xiamen, 361021, 
      China.
FAU - Fan, Jingqian
AU  - Fan J
AD  - College of Chemical Engineering, Huaqiao University, Xiamen, 361021, China.
FAU - Long, Ruimin
AU  - Long R
AD  - College of Chemical Engineering, Huaqiao University, Xiamen, 361021, China.
AD  - Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen, 361021, 
      China.
AD  - Fujian Provincial Key Laboratory of Biochemical Technology, Xiamen, 361021, 
      China.
FAU - Liu, Yuangang
AU  - Liu Y
AD  - College of Chemical Engineering, Huaqiao University, Xiamen, 361021, China. 
      ygliu@hqu.edu.cn.
AD  - Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen, 361021, 
      China. ygliu@hqu.edu.cn.
AD  - Fujian Provincial Key Laboratory of Biochemical Technology, Xiamen, 361021, 
      China. ygliu@hqu.edu.cn.
FAU - Wang, Shibin
AU  - Wang S
AD  - College of Chemical Engineering, Huaqiao University, Xiamen, 361021, China. 
      sbwang@hqu.edu.cn.
AD  - College of Materials Science and Engineering, Huaqiao University, Xiamen, 361021, 
      China. sbwang@hqu.edu.cn.
AD  - Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen, 361021, 
      China. sbwang@hqu.edu.cn.
AD  - Fujian Provincial Key Laboratory of Biochemical Technology, Xiamen, 361021, 
      China. sbwang@hqu.edu.cn.
LA  - eng
GR  - 16PYY007SF17/Financial support from National marine economic innovation and 
      development project/
GR  - WKJ2016-2-22/the Science Research Foundation of National Health and Family 
      Planning Commission of PRC & United Fujian Provincial Health and Education 
      Project for Tacking the Key Research/
GR  - 2014FJ-NCET-ZR01/the Program for New Century Excellent Talents in Fujian Province 
      University/
GR  - ZQN-PY108/the Promotion Program for Young and Middle-aged Teachers in Science and 
      Technology Research of Huaqiao University/
GR  - 17011081003/Subsidized Project for Postgraduates' Innovative Fund in Scientific 
      Research of Huaqiao University/
PT  - Journal Article
DEP - 20180510
PL  - United States
TA  - J Mater Sci Mater Med
JT  - Journal of materials science. Materials in medicine
JID - 9013087
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Drug Carriers)
RN  - 0 (Peptides)
RN  - 0 (Polymers)
RN  - 0 (Polysaccharides)
RN  - 25104-12-5 (polyornithine)
RN  - 80168379AG (Doxorubicin)
RN  - 9072-19-9 (fucoidan)
RN  - E524N2IXA3 (Ornithine)
RN  - H0G9379FGK (Calcium Carbonate)
SB  - IM
MH  - Animals
MH  - Calcium Carbonate/chemical synthesis/*chemistry
MH  - Cells, Cultured
MH  - Coated Materials, Biocompatible/*chemical synthesis/chemistry/pharmacokinetics
MH  - Doxorubicin/administration & dosage/pharmacokinetics
MH  - *Drug Carriers/chemical synthesis/chemistry/pharmacokinetics
MH  - Drug Delivery Systems
MH  - Drug Liberation
MH  - Humans
MH  - MCF-7 Cells
MH  - Materials Testing
MH  - Mice
MH  - *Neoplasms/diagnosis/therapy
MH  - Ornithine/chemistry
MH  - Peptides/*chemistry
MH  - Polymerization
MH  - Polymers/chemical synthesis/chemistry
MH  - Polysaccharides/*chemistry
MH  - Theranostic Nanomedicine/*methods
EDAT- 2018/05/12 06:00
MHDA- 2018/10/12 06:00
CRDT- 2018/05/12 06:00
PHST- 2017/09/07 00:00 [received]
PHST- 2018/04/21 00:00 [accepted]
PHST- 2018/05/12 06:00 [entrez]
PHST- 2018/05/12 06:00 [pubmed]
PHST- 2018/10/12 06:00 [medline]
AID - 10.1007/s10856-018-6075-z [pii]
AID - 10.1007/s10856-018-6075-z [doi]
PST - epublish
SO  - J Mater Sci Mater Med. 2018 May 10;29(5):68. doi: 10.1007/s10856-018-6075-z.