PMID- 29749265
OWN - NLM
STAT- MEDLINE
DCOM- 20190618
LR  - 20190618
IS  - 2169-141X (Electronic)
IS  - 2169-1401 (Linking)
VI  - 46
IP  - sup2
DP  - 2018
TI  - Injectable visible light-cured glycol chitosan hydrogels with controlled release 
      of anticancer drugs for local cancer therapy in vivo: a feasible study.
PG  - 874-882
LID - 10.1080/21691401.2018.1470529 [doi]
AB  - Currently available chemotherapy is associated with serious side effects, and 
      therefore novel drug delivery systems (DDSs) are required to specifically deliver 
      anticancer drugs to targeted sites. In this study, we evaluated the feasibility 
      of visible light-cured glycol chitosan (GC) hydrogels with controlled release of 
      doxorubicin⋅hydrochloride (DOX⋅HCl) as local DDSs for effective cancer therapy in 
      vivo. The storage modulus of the hydrogel precursor solutions was increased as a 
      function of visible light irradiation time. In addition, the swelling ratio of 
      the hydrogel irradiated for 10 s (GC(10)/DOX) was greater than in 60 s 
      (GC(60)/DOX). In vitro release test showed that DOX was rapidly released in 
      GC(10)/DOX compared with GC(60)/DOX due to the density of cross-linking. In vitro 
      and in vivo tests including cell viability and measurement of tumor volume showed 
      that the local treatment of GC(10)/DOX yielded substantially greater antitumor 
      effect compared with that of GC(60)/DOX. Therefore, the visible light-cured GC 
      hydrogel system may exhibit clinical potential as a local DDS of anticancer drugs 
      with controlled release, by modulating cross-linking density.
FAU - Hyun, Hoon
AU  - Hyun H
AD  - a Department of Biomedical Sciences , Chonnam National University Medical School 
      , Gwangju , Republic of Korea.
FAU - Park, Min Ho
AU  - Park MH
AD  - b Department of Surgery , Chonnam National University Medical School , Gwangju , 
      Republic of Korea.
FAU - Lim, Wonbong
AU  - Lim W
AD  - c Department of Premedical Program, School of Medicine , Chosun University , 
      Gwangju , Republic of Korea.
FAU - Kim, So Yeon
AU  - Kim SY
AD  - d Department of Dental Hygiene, College of Health Sciences , Cheongju University 
      , Cheongju , Republic of Korea.
FAU - Jo, Danbi
AU  - Jo D
AD  - a Department of Biomedical Sciences , Chonnam National University Medical School 
      , Gwangju , Republic of Korea.
FAU - Jung, Jin Seok
AU  - Jung JS
AD  - a Department of Biomedical Sciences , Chonnam National University Medical School 
      , Gwangju , Republic of Korea.
FAU - Jo, Gayoung
AU  - Jo G
AD  - a Department of Biomedical Sciences , Chonnam National University Medical School 
      , Gwangju , Republic of Korea.
FAU - Um, Sewook
AU  - Um S
AD  - e Department of Veterinary Surgery, College of Veterinary Medicine , Seoul 
      National University , Seoul , Republic of Korea.
FAU - Lee, Deok-Won
AU  - Lee DW
AD  - f Department of Oral and Maxillofacial Surgery , Kyung Hee University Dental 
      Hospital at Gangdong, Kyung Hee University , Seoul , Republic of Korea.
FAU - Yang, Dae Hyeok
AU  - Yang DH
AD  - g Institute of Cell and Tissue Engineering, College of Medicine , The Catholic 
      University of Korea , Seoul , Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20180511
PL  - England
TA  - Artif Cells Nanomed Biotechnol
JT  - Artificial cells, nanomedicine, and biotechnology
JID - 101594777
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Hydrogels)
RN  - 0 (glycol-chitosan)
RN  - 80168379AG (Doxorubicin)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*chemistry/*pharmacology
MH  - Cell Survival/drug effects
MH  - Chitosan/*chemistry
MH  - Delayed-Action Preparations
MH  - Doxorubicin/*chemistry/*pharmacology
MH  - Feasibility Studies
MH  - Humans
MH  - Hydrogels/*chemistry
MH  - Injections
MH  - *Light
MH  - MCF-7 Cells
MH  - Mice
MH  - Xenograft Model Antitumor Assays
OTO - NOTNLM
OT  - Glycol chitosan
OT  - cross-linking density
OT  - doxorubicin⋅hydrochloride
OT  - local drug delivery system
OT  - visible light irradiation
EDAT- 2018/05/12 06:00
MHDA- 2019/06/19 06:00
CRDT- 2018/05/12 06:00
PHST- 2018/05/12 06:00 [pubmed]
PHST- 2019/06/19 06:00 [medline]
PHST- 2018/05/12 06:00 [entrez]
AID - 10.1080/21691401.2018.1470529 [doi]
PST - ppublish
SO  - Artif Cells Nanomed Biotechnol. 2018;46(sup2):874-882. doi: 
      10.1080/21691401.2018.1470529. Epub 2018 May 11.