PMID- 29749437
OWN - NLM
STAT- MEDLINE
DCOM- 20181002
LR  - 20190221
IS  - 1791-2423 (Electronic)
IS  - 1019-6439 (Linking)
VI  - 53
IP  - 1
DP  - 2018 Jul
TI  - Oncogenic IL7R is downregulated by histone deacetylase inhibitor in esophageal 
      squamous cell carcinoma via modulation of acetylated FOXO1.
PG  - 395-403
LID - 10.3892/ijo.2018.4392 [doi]
AB  - The interleukin-7 receptor (IL7R) is generally expressed in immune cells and is 
      critical in survival, development and homeostasis in the immune system. Advanced 
      genome-wide cancer studies have reported that IL7R is genetically amplified in 
      human esophageal squamous cell carcinoma (ESCC), however, the exact role of IL7R 
      in ESCC has not been investigated. In the present study, it was found that IL7R 
      was overexpressed in ESCC cohorts and the loss of IL7R induced anti-oncogenic 
      effects in ESCC cell lines. A small panel of epigenetic drugs were screened for 
      their ability to downregulate the expression of IL7R. Unexpectedly, apicidin, a 
      histone deacetylase (HDAC) inhibitor, effectively downregulated the expression of 
      IL7R in a dose-dependent manner at an early time-point, as determined by 
      quantitative polymerase chain reaction and IL7R immunostaining, and did not 
      require de novo protein synthesis. Of note, apicidin induced the acetylation of 
      Forkhead box-containing protein, O subfamily 1, which acts as a repressor at the 
      IL7R promoter, accompanied with depleted active histone modifications based on 
      chromatin immunoprecipitation assay. Taken together, these results demonstrated 
      that targeting oncogenic IL7R in ESCC by HDAC inhibitors may be a valuable 
      therapeutic approach.
FAU - Kim, Myoung Jun
AU  - Kim MJ
AD  - Department of Biochemistry, Research Institute of Medical Science, School of 
      Medicine, Konkuk University, Seoul 05029, Republic of Korea.
FAU - Choi, Sung Kyung
AU  - Choi SK
AD  - Department of Biochemistry, Research Institute of Medical Science, School of 
      Medicine, Konkuk University, Seoul 05029, Republic of Korea.
FAU - Hong, Seong Hwi
AU  - Hong SH
AD  - Department of Biochemistry, Research Institute of Medical Science, School of 
      Medicine, Konkuk University, Seoul 05029, Republic of Korea.
FAU - Eun, Jung Woo
AU  - Eun JW
AD  - Functional RNomics Research Center, College of Medicine, The Catholic University, 
      Seoul 06591, Republic of Korea.
FAU - Nam, Suk Woo
AU  - Nam SW
AD  - Functional RNomics Research Center, College of Medicine, The Catholic University, 
      Seoul 06591, Republic of Korea.
FAU - Han, Jeung-Whan
AU  - Han JW
AD  - Research Center for Epigenome Regulation, School of Pharmacy, Sungkyunkwan 
      University, Suwon 16419, Republic of Korea.
FAU - You, Jueng Soo
AU  - You JS
AD  - Department of Biochemistry, Research Institute of Medical Science, School of 
      Medicine, Konkuk University, Seoul 05029, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20180502
PL  - Greece
TA  - Int J Oncol
JT  - International journal of oncology
JID - 9306042
RN  - 0 (FOXO1 protein, human)
RN  - 0 (Forkhead Box Protein O1)
RN  - 0 (Histone Deacetylase Inhibitors)
RN  - 0 (IL7R protein, human)
RN  - 0 (Interleukin-7 Receptor alpha Subunit)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (apicidin)
SB  - IM
MH  - Acetylation/drug effects
MH  - Apoptosis/drug effects
MH  - Carcinoma, Squamous Cell/*drug therapy/genetics/pathology
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Esophageal Neoplasms/*drug therapy/genetics/pathology
MH  - Esophageal Squamous Cell Carcinoma
MH  - Forkhead Box Protein O1/*genetics
MH  - Gene Expression Regulation, Neoplastic/drug effects
MH  - Histone Deacetylase Inhibitors/*pharmacology
MH  - Humans
MH  - Interleukin-7 Receptor alpha Subunit/*genetics
MH  - Peptides, Cyclic/pharmacology
EDAT- 2018/05/12 06:00
MHDA- 2018/10/03 06:00
CRDT- 2018/05/12 06:00
PHST- 2018/01/01 00:00 [received]
PHST- 2018/04/18 00:00 [accepted]
PHST- 2018/05/12 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2018/05/12 06:00 [entrez]
AID - 10.3892/ijo.2018.4392 [doi]
PST - ppublish
SO  - Int J Oncol. 2018 Jul;53(1):395-403. doi: 10.3892/ijo.2018.4392. Epub 2018 May 2.