PMID- 29749710
OWN - NLM
STAT- MEDLINE
DCOM- 20190719
LR  - 20240519
IS  - 1751-7893 (Electronic)
IS  - 1751-7885 (Print)
IS  - 1751-7885 (Linking)
VI  - 13
IP  - 1
DP  - 2019 Feb
TI  - Attenuated psychotic symptom interventions in youth at risk of psychosis: A 
      systematic review and meta-analysis.
PG  - 3-17
LID - 10.1111/eip.12677 [doi]
AB  - AIM: Attenuated psychotic symptoms (APSs) have been the primary emphasis in youth 
      at clinical high risk (CHR) for psychosis for assessing symptomology and 
      determining subsequent transition to a psychotic disorder. Previous reviews 
      primarily focused on the efficacy of cognitive behavioural therapy (CBT) on APS; 
      however, a comprehensive assessment of other interventions to date is lacking. 
      Therefore, we conducted a systematic review and meta-analysis of all intervention 
      studies examining APS in CHR youth. METHOD: The authors searched Embase, CINAHL, 
      PsycINFO, Medline and EBM from inception to May 2017. Studies were selected if 
      they included any intervention that reported follow-up APS in youth at CHR. 
      Interventions were evaluated and stratified by time using both pairwise and 
      network meta-analyses (NMAs). Due to the differences in APS scales, effect sizes 
      were calculated as Hedges g and reported as the standardized mean difference 
      (SMD). RESULTS: Forty-one studies met our inclusion criteria. In pairwise 
      meta-analyses, CBT was associated with a trend towards reduction in APS compared 
      to controls at 12-months. In the NMA, integrated psychological therapy, CBT, 
      supportive therapy, family therapy, needs-based interventions, omega-3, 
      risperidone plus CBT and olanzapine were not significantly more effective at 
      reducing APS at 6 and 12 months relative to any other intervention. CONCLUSIONS: 
      CBT demonstrated a slight trend at reducing APS at long-term follow-up compared 
      to controls. No interventions were significantly more effective at reducing APS 
      compared to all other interventions in the NMA. [Correction added on 4 June 2018, 
      after first online publication: Some parts of the Abstract section particularly 
      'Results' and 'Conclusions' have been corrected.].
CI  - (c) 2018 John Wiley & Sons Australia, Ltd.
FAU - Devoe, Daniel J
AU  - Devoe DJ
AD  - Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, 
      Alberta, Canada.
FAU - Farris, Megan S
AU  - Farris MS
AD  - Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, 
      Alberta, Canada.
FAU - Townes, Parker
AU  - Townes P
AD  - Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, 
      Alberta, Canada.
FAU - Addington, Jean
AU  - Addington J
AUID- ORCID: 0000-0002-8298-0756
AD  - Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, 
      Alberta, Canada.
LA  - eng
GR  - R01 MH105178/MH/NIMH NIH HHS/United States
GR  - RO1MH105178/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20180511
PL  - Australia
TA  - Early Interv Psychiatry
JT  - Early intervention in psychiatry
JID - 101320027
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Fatty Acids, Omega-3)
SB  - IM
MH  - Antipsychotic Agents/*therapeutic use
MH  - Fatty Acids, Omega-3/*therapeutic use
MH  - Humans
MH  - *Psychotherapy
MH  - Psychotic Disorders/diet therapy/drug therapy/*therapy
PMC - PMC6230498
MID - NIHMS962862
OTO - NOTNLM
OT  - clinical high risk
OT  - meta-analysis
OT  - schizophrenia
OT  - systematic review
EDAT- 2018/05/12 06:00
MHDA- 2019/07/20 06:00
PMCR- 2020/02/01
CRDT- 2018/05/12 06:00
PHST- 2017/12/04 00:00 [received]
PHST- 2018/02/20 00:00 [revised]
PHST- 2018/03/13 00:00 [accepted]
PHST- 2018/05/12 06:00 [pubmed]
PHST- 2019/07/20 06:00 [medline]
PHST- 2018/05/12 06:00 [entrez]
PHST- 2020/02/01 00:00 [pmc-release]
AID - 10.1111/eip.12677 [doi]
PST - ppublish
SO  - Early Interv Psychiatry. 2019 Feb;13(1):3-17. doi: 10.1111/eip.12677. Epub 2018 
      May 11.