PMID- 29750194
OWN - NLM
STAT- MEDLINE
DCOM- 20190912
LR  - 20190912
IS  - 2375-2548 (Electronic)
IS  - 2375-2548 (Linking)
VI  - 4
IP  - 5
DP  - 2018 May
TI  - Thirdhand smoke uptake to aerosol particles in the indoor environment.
PG  - eaap8368
LID - 10.1126/sciadv.aap8368 [doi]
LID - eaap8368
AB  - Aerosol composition measurements made in an indoor classroom indicate the uptake 
      of thirdhand smoke (THS) species to indoor particles, a novel exposure route for 
      THS to humans indoors. Chemical speciation of the organic aerosol fraction using 
      mass spectrometric data and factor analysis identified a reduced nitrogen 
      component, predominantly found in the indoor environment, contributing 29% of the 
      indoor submicron aerosol mass. We identify this factor as THS compounds 
      partitioning from interior surfaces to gas phase and then aerosol phase. 
      Partitioning of THS vapors to aerosols requires an aqueous phase for reactive 
      uptake of the reduced nitrogen species (RdNS), leading to seasonal differences in 
      THS concentration indoors. RdNS protonate under the acidic conditions expected 
      for indoor aerosols of outdoor origin. Controlled laboratory measurements 
      performed using cigarette smoke deposited into a Pyrex vessel showed a similar 
      partitioning behavior to aerosol of outdoor origin and mass spectral features 
      comparable to the measured indoor THS factor after 1 week of residence time in 
      the closed vessel. This study reports a new, potentially large THS exposure route 
      from partitioning of surface volatile organic compounds into the aerosol phase 
      and subsequent dispersion in a mechanically ventilated building.
FAU - DeCarlo, Peter F
AU  - DeCarlo PF
AUID- ORCID: 0000-0001-6385-7149
AD  - Department of Civil, Architectural, and Environmental Engineering, Drexel 
      University, Philadelphia, PA 19104, USA.
AD  - Department of Chemistry, Drexel University, Philadelphia, PA 19104, USA.
FAU - Avery, Anita M
AU  - Avery AM
AD  - Department of Civil, Architectural, and Environmental Engineering, Drexel 
      University, Philadelphia, PA 19104, USA.
FAU - Waring, Michael S
AU  - Waring MS
AD  - Department of Civil, Architectural, and Environmental Engineering, Drexel 
      University, Philadelphia, PA 19104, USA.
LA  - eng
SI  - Dryad/10.5061/dryad.f25c87j
GR  - P30 ES013508/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20180509
PL  - United States
TA  - Sci Adv
JT  - Science advances
JID - 101653440
RN  - 0 (Aerosols)
RN  - 0 (Tobacco Smoke Pollution)
RN  - N762921K75 (Nitrogen)
SB  - IM
MH  - *Aerosols/analysis/chemistry
MH  - *Air Pollution, Indoor/analysis
MH  - Humans
MH  - Nitrogen
MH  - Particle Size
MH  - Smoking
MH  - Tobacco Smoke Pollution/*adverse effects
PMC - PMC5942907
EDAT- 2018/05/12 06:00
MHDA- 2019/09/13 06:00
PMCR- 2018/05/09
CRDT- 2018/05/12 06:00
PHST- 2017/08/31 00:00 [received]
PHST- 2018/04/10 00:00 [accepted]
PHST- 2018/05/12 06:00 [entrez]
PHST- 2018/05/12 06:00 [pubmed]
PHST- 2019/09/13 06:00 [medline]
PHST- 2018/05/09 00:00 [pmc-release]
AID - aap8368 [pii]
AID - 10.1126/sciadv.aap8368 [doi]
PST - epublish
SO  - Sci Adv. 2018 May 9;4(5):eaap8368. doi: 10.1126/sciadv.aap8368. eCollection 2018 
      May.