PMID- 29750676
OWN - NLM
STAT- MEDLINE
DCOM- 20190520
LR  - 20190520
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 23
IP  - 4
DP  - 2018 Aug
TI  - Human leukocyte antigen matching in organ transplantation: what we know and how 
      can we make it better (Revisiting the past, improving the future).
PG  - 470-476
LID - 10.1097/MOT.0000000000000538 [doi]
AB  - PURPOSE OF REVIEW: A renaissance for human leukocyte antigen (HLA) testing 
      emerged with the understanding that donor-specific HLA antibodies play a 
      significant role in long-term allograft survival. This renewed focus on 
      donor/recipient histocompatibility led to a recent quest to decipher antibody 
      responses or, as introduced into the transplantation lexicon, 'HLA-epitope 
      matching'. RECENT FINDINGS: Whether matching is at the antigen or the epitope 
      level, in-depth understanding of how histo-incompatibility leads to activation of 
      an immune response is required. HLA-DQ donor-specific antibody (DSA) has the 
      highest association with poor graft survival. However, HLA-DQ antigens and 
      antibodies are understudied and significant gaps still exist in understanding the 
      function of HLA-DQ in immune activation. Much of our knowledge about HLA class-II 
      molecules is derived from studies performed on HLA-DR, whether it is 
      crystallography, antigen processing and presentation analysis, or activation of 
      T-cell signal-transduction pathways. Indeed, HLA-DQ molecules are less amenable 
      for laboratory testing, but the limited studies that were performed indicate that 
      HLA-DQ might have, at least to some extent, a different role compared with 
      HLA-DR. SUMMARY: This review highlights qualities of HLA-DQ that may be 
      associated with different pathways of activating an immune response. 
      Understanding the consequences of such differences may lead to better 
      appreciation and significance of HLA-DQ for matching purposes.
FAU - Tambur, Anat R
AU  - Tambur AR
AD  - Transplant Immunology Laboratory, Comprehensive Transplant Center, Feinberg 
      School of Medicine, Northwestern University, Chicago, Illinois, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Graft Rejection/immunology
MH  - Graft Survival/immunology
MH  - HLA-DQ Antigens/analysis/*immunology
MH  - HLA-DR Antigens
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Isoantibodies/immunology
MH  - Organ Transplantation/*methods
MH  - Tissue Donors
MH  - Transplantation Immunology
MH  - Transplantation, Homologous
EDAT- 2018/05/12 06:00
MHDA- 2019/05/21 06:00
CRDT- 2018/05/12 06:00
PHST- 2018/05/12 06:00 [pubmed]
PHST- 2019/05/21 06:00 [medline]
PHST- 2018/05/12 06:00 [entrez]
AID - 10.1097/MOT.0000000000000538 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2018 Aug;23(4):470-476. doi: 
      10.1097/MOT.0000000000000538.