PMID- 29750873
OWN - NLM
STAT- MEDLINE
DCOM- 20190121
LR  - 20190712
IS  - 1802-9973 (Electronic)
IS  - 0862-8408 (Linking)
VI  - 67
IP  - 4
DP  - 2018 Aug 16
TI  - The effect of superoxide dismutase enzyme inhibition on renal microcirculation of 
      spontaneously hypertensive-stroke prone and Wistar rats.
PG  - 535-541
AB  - A significant factor in the development of hypertension may be excessive 
      vasoconstriction within the renal medulla. This study therefore investigated the 
      role of superoxide dismutase (SOD) in the regulation of renal medullary and 
      cortical blood perfusion (MBP and CBP, respectively) in both stroke-prone 
      spontaneously hypertensive rats (SHRSP) and normotensive Wistar rats. CBP and MBP 
      were measured before and after intra-renal infusion of the SOD inhibitor, 
      diethyldithio-carbamic acid (DETC). Under basal conditions, mean arterial 
      pressure was significantly greater in SHRSP than Wistar rats, but both MBP and 
      heart rate (HR) were significantly lower in SHRSP relative to Wistar rats 
      (P<0.05, n=7 in both groups). Infusion of DETC (2 mg/kg/min) into the 
      cortico-medullary border area of the kidney significantly decreased MBP in the 
      SHRSPs (by 28+/-3 %, n=7, P<0.05), indicating a greater vasoconstriction within 
      this vascular bed. However, DETC also significantly decreased MBP in Wistar rats 
      to a similar extent (24+/-4 %, n=7, P<0.05). These results suggest that 
      superoxide anions play a significant role in reducing renal vascular compliance 
      within the renal medulla in both normotensive and hypertensive animals, although 
      the responses are not greater in the hypertensive relative to the control 
      animals.
FAU - Ahmeda, A F
AU  - Ahmeda AF
AD  - Department of Physiology, College of Medicine, King Saud University, Riyadh, 
      Kingdom of Saudi Arabia. aahmeda@ksu.edu.sa.
FAU - Rae, M G
AU  - Rae MG
FAU - Anweigi, L M
AU  - Anweigi LM
FAU - Al Otaibi, M F
AU  - Al Otaibi MF
FAU - Al-Masri, A A
AU  - Al-Masri AA
FAU - Johns, E J
AU  - Johns EJ
LA  - eng
PT  - Journal Article
DEP - 20180510
PL  - Czech Republic
TA  - Physiol Res
JT  - Physiological research
JID - 9112413
RN  - 0 (Enzyme Inhibitors)
RN  - 99Z2744345 (Ditiocarb)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - Ditiocarb/pharmacology
MH  - Enzyme Inhibitors/pharmacology
MH  - Hypertension/*enzymology/physiopathology
MH  - Kidney/blood supply/drug effects/*metabolism
MH  - Male
MH  - Microcirculation/drug effects/*physiology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Wistar
MH  - Superoxide Dismutase/*antagonists & inhibitors/*metabolism
EDAT- 2018/05/12 06:00
MHDA- 2019/01/22 06:00
CRDT- 2018/05/12 06:00
PHST- 2018/05/12 06:00 [pubmed]
PHST- 2019/01/22 06:00 [medline]
PHST- 2018/05/12 06:00 [entrez]
AID - 933655 [pii]
AID - 10.33549/physiolres.933655 [doi]
PST - ppublish
SO  - Physiol Res. 2018 Aug 16;67(4):535-541. doi: 10.33549/physiolres.933655. Epub 
      2018 May 10.