PMID- 29750944
OWN - NLM
STAT- MEDLINE
DCOM- 20190809
LR  - 20190809
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 192
DP  - 2018 Aug
TI  - Ellipsoid Zone Change According to Glaucoma Stage Advancement.
PG  - 1-9
LID - S0002-9394(18)30206-X [pii]
LID - 10.1016/j.ajo.2018.04.025 [doi]
AB  - PURPOSE: To compare retinal photoreceptor ellipsoid zone (EZ) intensity between 
      normal eyes and those with different stages of glaucoma. DESIGN: Retrospective 
      cross-sectional study. METHODS: The study included 37 normal, 38 preperimetric 
      glaucoma, 39 mild-to-moderate glaucoma (visual field [VF] mean deviation 
      [MD]: -7.7 +/- 2.0 dB), and 36 severe glaucoma eyes (VF MD: -17.8 +/- 3.2 dB). The 
      subjects underwent high-resolution horizontal and vertical line scans through the 
      fovea by spectral-domain optical coherence tomography (SD-OCT). Image processing 
      software was employed to quantify the intensity of the first and second 
      hyperreflective bands corresponding with the external limiting membrane (ELM) and 
      EZ. In order to account for the brightness variation among scans, the relative EZ 
      intensity as the ratio of the second to first reflective band (EZ/ELM) was 
      determined. RESULTS: The relative EZ intensity in severe glaucoma eyes was 
      significantly lower than in mild-to-moderate glaucoma eyes (2.46 +/- 0.38 vs 3.15 +/- 
      0.43, P < .001); also, it was lower in mild-to-moderate than in preperimetric 
      glaucoma eyes (3.15 +/- 0.43 vs 3.86 +/- 0.44, P < .001). However, the comparison 
      between preperimetric glaucoma and normal eyes showed no significant difference 
      (3.86 +/- 0.44 vs 4.06 +/- 0.40, P = .751). In 75 glaucomatous eyes with VF defect, 
      there was a significant correlation between relative EZ intensity and VF MD (r = 
      0.83 and P < .001). CONCLUSIONS: According to SD-OCT, relative EZ intensity 
      reduction occurs in the mild-to-moderate and severe glaucoma stages. These 
      findings suggest, at least provisionally, that in the course of glaucoma 
      progression, mitochondrial changes in the inner segments of photoreceptors occur. 
      Further investigation is warranted to evaluate the potential clinical 
      significance of EZ intensity reduction in glaucoma.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Ha, Ahnul
AU  - Ha A
AD  - Department of Medicine, Seoul National University College of Medicine, Seoul, 
      South Korea; and Department of Ophthalmology, Seoul National University Hospital, 
      Seoul, South Korea.
FAU - Kim, Young Kook
AU  - Kim YK
AD  - Department of Medicine, Seoul National University College of Medicine, Seoul, 
      South Korea; and Department of Ophthalmology, Seoul National University Hospital, 
      Seoul, South Korea.
FAU - Jeoung, Jin Wook
AU  - Jeoung JW
AD  - Department of Medicine, Seoul National University College of Medicine, Seoul, 
      South Korea; and Department of Ophthalmology, Seoul National University Hospital, 
      Seoul, South Korea.
FAU - Park, Ki Ho
AU  - Park KH
AD  - Department of Medicine, Seoul National University College of Medicine, Seoul, 
      South Korea; and Department of Ophthalmology, Seoul National University Hospital, 
      Seoul, South Korea. Electronic address: kihopark@snu.ac.kr.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20180508
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
CIN - Am J Ophthalmol. 2019 Jan;197:183. PMID: 30297219
CIN - Am J Ophthalmol. 2019 Jan;197:183-184. PMID: 30309610
MH  - Cross-Sectional Studies
MH  - Disease Progression
MH  - Female
MH  - Glaucoma, Open-Angle/classification/*diagnosis
MH  - Gonioscopy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Retinal Diseases/*diagnosis
MH  - Retinal Ganglion Cells/pathology
MH  - Retinal Photoreceptor Cell Inner Segment/*pathology
MH  - Retrospective Studies
MH  - Slit Lamp Microscopy
MH  - Tomography, Optical Coherence
MH  - Tonometry, Ocular
MH  - Vision Disorders/diagnosis/physiopathology
MH  - Visual Field Tests
MH  - Visual Fields/physiology
EDAT- 2018/05/12 06:00
MHDA- 2019/08/10 06:00
CRDT- 2018/05/12 06:00
PHST- 2018/01/31 00:00 [received]
PHST- 2018/04/24 00:00 [revised]
PHST- 2018/04/28 00:00 [accepted]
PHST- 2018/05/12 06:00 [pubmed]
PHST- 2019/08/10 06:00 [medline]
PHST- 2018/05/12 06:00 [entrez]
AID - S0002-9394(18)30206-X [pii]
AID - 10.1016/j.ajo.2018.04.025 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2018 Aug;192:1-9. doi: 10.1016/j.ajo.2018.04.025. Epub 2018 May 
      8.