PMID- 29750970 OWN - NLM STAT- MEDLINE DCOM- 20190425 LR - 20190425 IS - 1095-6867 (Electronic) IS - 0018-506X (Linking) VI - 102 DP - 2018 Jun TI - BDNF infusion into the MPN mag is sufficient to restore copulatory behavior in the castrated Syrian hamster. PG - 69-75 LID - S0018-506X(18)30016-3 [pii] LID - 10.1016/j.yhbeh.2018.05.006 [doi] AB - Testosterone plays a key role in the expression of male sex behavior by influencing cellular activity and synapses within the magnocellular medial preoptic nucleus (MPN mag), a sub-nucleus of the medial preoptic area (MPOA) in the Syrian hamster. Although the mechanisms underlying hormonally-induced synaptic plasticity in this region remain elusive, the data suggests that an increase in synaptic density may mediate testosterone's effects on copulation. As brain derived neurotrophic factor (BDNF) plays an integral role in regulating synaptic plasticity and gonadal steroids regulate the levels of BDNF, we hypothesize that BDNF may mediate the effects of gonadal hormones on copulatory behavior. To test this hypothesis, we infused BDNF or controls into the MPN mag of long-term castrates. Our results indicate that BDNF, but not the controls, restored copulatory behavior in castrated male Syrian hamsters. Furthermore, the rise of BDNF expression in the MPOA preceded the rise of synaptophysin following testosterone replacement in castrated males. These data are consistent with our hypothesis, implicating a role for BDNF in mediating testosterone's action on copulation and suggest that the delay in testosterone's restoration of copulation is, in part, due to the delay in the increase of BDNF and synaptophysin. CI - Copyright (c) 2018 Elsevier Inc. All rights reserved. FAU - Brague, Joe C AU - Brague JC AD - Lsehigh University, Department of Biological Sciences, Iacocca Hall, 111 Research Dr., Bethlehem, PA 18015, United States. Electronic address: joebrague@gmail.com. FAU - Lenchur, Christine N AU - Lenchur CN AD - Lsehigh University, Department of Biological Sciences, Iacocca Hall, 111 Research Dr., Bethlehem, PA 18015, United States. Electronic address: cnl218@lehigh.edu. FAU - Hayden, Julia M AU - Hayden JM AD - Lsehigh University, Department of Biological Sciences, Iacocca Hall, 111 Research Dr., Bethlehem, PA 18015, United States. Electronic address: jmh218@lehigh.edu. FAU - Davidson, Rachel H AU - Davidson RH AD - Lsehigh University, Department of Biological Sciences, Iacocca Hall, 111 Research Dr., Bethlehem, PA 18015, United States. Electronic address: rhd417@lehigh.edu. FAU - Corrigan, Kelly AU - Corrigan K AD - Lsehigh University, Department of Biological Sciences, Iacocca Hall, 111 Research Dr., Bethlehem, PA 18015, United States. Electronic address: kac217@lehigh.edu. FAU - Santini, Garrett T AU - Santini GT AD - Lsehigh University, Department of Biological Sciences, Iacocca Hall, 111 Research Dr., Bethlehem, PA 18015, United States. Electronic address: gts218@lehigh.edu. FAU - Swann, Jennifer M AU - Swann JM AD - Lsehigh University, Department of Biological Sciences, Iacocca Hall, 111 Research Dr., Bethlehem, PA 18015, United States. Electronic address: jms5@lehigh.edu. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180512 PL - United States TA - Horm Behav JT - Hormones and behavior JID - 0217764 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Gonadal Steroid Hormones) RN - 3XMK78S47O (Testosterone) SB - IM MH - Animals MH - Brain-Derived Neurotrophic Factor/*administration & dosage MH - Copulation/*drug effects MH - Cricetinae MH - Gonadal Steroid Hormones/metabolism MH - Infusions, Intraventricular MH - Male MH - Mesocricetus MH - *Orchiectomy/veterinary MH - Preoptic Area/*drug effects MH - Sexual Behavior, Animal/*drug effects MH - Testosterone/metabolism OTO - NOTNLM OT - BDNF OT - Male sex behavior OT - Synaptophysin OT - Testosterone EDAT- 2018/05/12 06:00 MHDA- 2019/04/26 06:00 CRDT- 2018/05/12 06:00 PHST- 2018/01/16 00:00 [received] PHST- 2018/05/03 00:00 [revised] PHST- 2018/05/06 00:00 [accepted] PHST- 2018/05/12 06:00 [pubmed] PHST- 2019/04/26 06:00 [medline] PHST- 2018/05/12 06:00 [entrez] AID - S0018-506X(18)30016-3 [pii] AID - 10.1016/j.yhbeh.2018.05.006 [doi] PST - ppublish SO - Horm Behav. 2018 Jun;102:69-75. doi: 10.1016/j.yhbeh.2018.05.006. Epub 2018 May 12.