PMID- 29751171
OWN - NLM
STAT- MEDLINE
DCOM- 20191023
LR  - 20221207
IS  - 1873-3336 (Electronic)
IS  - 0304-3894 (Linking)
VI  - 354
DP  - 2018 Jul 15
TI  - Oxidation of cefalexin by thermally activated persulfate: Kinetics, products, and 
      antibacterial activity change.
PG  - 153-160
LID - S0304-3894(18)30343-1 [pii]
LID - 10.1016/j.jhazmat.2018.05.004 [doi]
AB  - While the widely used beta-lactam antibiotics, such as cephalosporins, are known to 
      be susceptible to oxidation by sulfate radical (SO(4)(-)), comprehensive study 
      about SO(4)(-)-induced oxidation of cephalosporins is still limited, such as the 
      impact of water matrices, and the structure and antibacterial activity of 
      transformation products. Herein, the oxidation of cefalexin (CFX), a most 
      frequently detected cephalosporin, was systematically investigated by thermally 
      activated persulfate (PS). CFX oxidation followed pseudo-first-order kinetics, 
      and SO(4)(-) dominantly contributed to the overall oxidation of CFX. The impact 
      of water matrices, such as Cl(-), HCO(3)(-) and natural organic matter, on CFX 
      degradation was predicted using a pseudo-steady-state kinetic model. The 
      secondary reactive species, such as chlorine and carbonate radicals, were found 
      to contribute to CFX degradation. Product analysis indicated oxidation of CFX to 
      six products (molecular weight of 363), with two stereoisomeric sulfoxides as the 
      primary oxidation products. It was thus suggested that the primary amine on the 
      side chain, and the thioether sulfur and double bond on the six-membered ring 
      were the reactive sites of CFX towards SO(4)(-) oxidation. Antibacterial activity 
      assessment showed that the biological activity of CFX solution was significantly 
      diminished after treatment by the thermally activated PS.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Qian, Yajie
AU  - Qian Y
AD  - College of Environmental Science and Engineering, Donghua University, Shanghai, 
      201620, PR China.
FAU - Xue, Gang
AU  - Xue G
AD  - College of Environmental Science and Engineering, Donghua University, Shanghai, 
      201620, PR China.
FAU - Chen, Jiabin
AU  - Chen J
AD  - School of Environmental Science and Engineering, Suzhou University of Science and 
      Technology, Suzhou, 215009, PR China. Electronic address: chenjiabincn@163.com.
FAU - Luo, Jinming
AU  - Luo J
AD  - School of Civil and Environmental Engineering, Georgia Institute of Technology, 
      Atlanta, Georgia, 30332, United States.
FAU - Zhou, Xuefei
AU  - Zhou X
AD  - College of Environmental Science and Engineering, Tongji University, Shanghai, 
      200092, PR China.
FAU - Gao, Pin
AU  - Gao P
AD  - College of Environmental Science and Engineering, Donghua University, Shanghai, 
      201620, PR China.
FAU - Wang, Qi
AU  - Wang Q
AD  - College of Environmental Science and Engineering, Donghua University, Shanghai, 
      201620, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180503
PL  - Netherlands
TA  - J Hazard Mater
JT  - Journal of hazardous materials
JID - 9422688
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Sulfates)
RN  - 0 (Waste Water)
RN  - 0 (Water Pollutants, Chemical)
RN  - 0 (sulfate radical)
RN  - OBN7UDS42Y (Cephalexin)
SB  - IM
MH  - Anti-Bacterial Agents/*chemistry/pharmacology
MH  - Cephalexin/*chemistry/pharmacology
MH  - Escherichia coli/drug effects/growth & development
MH  - Groundwater
MH  - Kinetics
MH  - Oxidation-Reduction
MH  - Sulfates/*chemistry
MH  - Temperature
MH  - Waste Disposal, Fluid/methods
MH  - Wastewater
MH  - Water Pollutants, Chemical/*chemistry/pharmacology
OTO - NOTNLM
OT  - Antibacterial activity
OT  - Cefalexin
OT  - Persulfate
OT  - Transformation
OT  - Water matrix
EDAT- 2018/05/12 06:00
MHDA- 2019/10/24 06:00
CRDT- 2018/05/12 06:00
PHST- 2018/01/14 00:00 [received]
PHST- 2018/04/10 00:00 [revised]
PHST- 2018/05/02 00:00 [accepted]
PHST- 2018/05/12 06:00 [pubmed]
PHST- 2019/10/24 06:00 [medline]
PHST- 2018/05/12 06:00 [entrez]
AID - S0304-3894(18)30343-1 [pii]
AID - 10.1016/j.jhazmat.2018.05.004 [doi]
PST - ppublish
SO  - J Hazard Mater. 2018 Jul 15;354:153-160. doi: 10.1016/j.jhazmat.2018.05.004. Epub 
      2018 May 3.