PMID- 29751492
OWN - NLM
STAT- MEDLINE
DCOM- 20181221
LR  - 20240326
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 15
IP  - 5
DP  - 2018 May 3
TI  - Aluminum Adjuvant-Containing Vaccines in the Context of the Hygiene Hypothesis: A 
      Risk Factor for Eosinophilia and Allergy in a Genetically Susceptible 
      Subpopulation?
LID - 10.3390/ijerph15050901 [doi]
LID - 901
AB  - There are similarities between the immune response following immunization with 
      aluminum adjuvants and the immune response elicited by some helminthic parasites, 
      including stimulation of immunoglobulin E (IgE) and eosinophilia. Immunization 
      with aluminum adjuvants, as with helminth infection, induces a Th2 type cell 
      mediated immune response, including eosinophilia, but does not induce an 
      environment conducive to the induction of regulatory mechanisms. Helminths play a 
      role in what is known as the hygiene hypothesis, which proposes that decreased 
      exposure to microbes during a critical time in early life has resulted in the 
      increased prevalence and morbidity of asthma and atopic disorders over the past 
      few decades, especially in Western countries. In addition, gut and lung 
      microbiome composition and their interaction with the immune system plays an 
      important role in a properly regulated immune system. Disturbances in microbiome 
      composition are a risk factor for asthma and allergies. We propose that 
      immunization with aluminum adjuvants in general is not favorable for induction of 
      regulatory mechanisms and, in the context of the hygiene hypothesis and 
      microbiome theory, can be viewed as an amplifying factor and significant 
      contributing risk factor for allergic diseases, especially in a genetically 
      susceptible subpopulation.
FAU - Terhune, Todd D
AU  - Terhune TD
AD  - College of Pharmacy, Department of Pharmaceutical Sciences, Nova Southeastern 
      University, 1382 Terry Bldg, 3200 South University Drive, Fort Lauderdale, FL 
      33328, USA. toddterhune@comcast.net.
FAU - Deth, Richard C
AU  - Deth RC
AD  - College of Pharmacy, Department of Pharmaceutical Sciences, Nova Southeastern 
      University, 1382 Terry Bldg, 3200 South University Drive, Fort Lauderdale, FL 
      33328, USA. rdeth@nova.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180503
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Vaccines)
RN  - CPD4NFA903 (Aluminum)
SB  - IM
MH  - Adjuvants, Immunologic/*administration & dosage
MH  - Aluminum/*administration & dosage
MH  - Animals
MH  - *Eosinophilia/genetics/immunology
MH  - Genetic Predisposition to Disease
MH  - Helminthiasis/immunology
MH  - Humans
MH  - Hygiene Hypothesis
MH  - *Hypersensitivity/genetics/immunology
MH  - Immunization
MH  - Microbiota
MH  - Risk Factors
MH  - Vaccines/*administration & dosage
PMC - PMC5981940
OTO - NOTNLM
OT  - IgE
OT  - allergy
OT  - aluminum
OT  - asthma
OT  - eosinophil
OT  - hygiene hypothesis
OT  - vaccination
COIS- The authors declare no conflict of interest.
EDAT- 2018/05/13 06:00
MHDA- 2018/12/24 06:00
PMCR- 2018/05/01
CRDT- 2018/05/13 06:00
PHST- 2018/03/28 00:00 [received]
PHST- 2018/04/19 00:00 [revised]
PHST- 2018/04/29 00:00 [accepted]
PHST- 2018/05/13 06:00 [entrez]
PHST- 2018/05/13 06:00 [pubmed]
PHST- 2018/12/24 06:00 [medline]
PHST- 2018/05/01 00:00 [pmc-release]
AID - ijerph15050901 [pii]
AID - ijerph-15-00901 [pii]
AID - 10.3390/ijerph15050901 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2018 May 3;15(5):901. doi: 
      10.3390/ijerph15050901.