PMID- 29751609
OWN - NLM
STAT- MEDLINE
DCOM- 20180926
LR  - 20190725
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 23
IP  - 5
DP  - 2018 May 11
TI  - Pterostilbene and 4'-Methoxyresveratrol Inhibited Lipopolysaccharide-Induced 
      Inflammatory Response in RAW264.7 Macrophages.
LID - 10.3390/molecules23051148 [doi]
LID - 1148
AB  - Pterostilbene (Pte) and 4'-Methoxyresveratrol (4MR) are methylated derivatives of 
      resveratrol. We investigated the anti-inflammatory effect of Pte and 4MR in 
      lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophages. Both Pte and 4MR 
      significantly reduced LPS-induced nitric oxide release by inhibiting the 
      inducible nitric oxide synthase mRNA expression. Moreover, both of them inhibited 
      LPS-induced mRNA expression of inflammatory cytokines including monocyte 
      chemoattractant protein (MCP)-1, interleukin (IL)-6 and IL-1beta, and tumor necrosis 
      factor alpha (TNF-alpha), and attenuated LPS-induced nuclear factor-kappaB (NF-kappaB) activation 
      by decreasing p65 phosphorylation. In addition, 4MR but not Pte inhibited 
      LPS-induced the activator protein (AP)-1 pathway in RAW 264.7 macrophages. 
      Further study suggested that Pte had an inhibitory effect on extracellular 
      regulated protein kinases (ERK) and p38 activation, but not on c-Jun N-terminal 
      kinase (JNK), while 4MR had an inhibitory effect on JNK and p38 activation, but 
      not on ERK. Taken together, our data suggested that Pte induced anti-inflammatory 
      activity by blocking mitogen-activated protein kinase (MAPK) and NF-kappaB signaling 
      pathways, while 4MR showed anti-inflammatory activity through suppression of 
      MAPK, AP-1, and NF-kappaB signaling pathways in LPS-treated RAW 264.7 macrophages.
FAU - Yao, Yun
AU  - Yao Y
AD  - College of Food Science and Technology, Shanghai Ocean University, No.999 
      Hu-Cheng-Huan Road, Shanghai 201306, China. yaoyun0111@163.com.
FAU - Liu, Kehai
AU  - Liu K
AD  - College of Food Science and Technology, Shanghai Ocean University, No.999 
      Hu-Cheng-Huan Road, Shanghai 201306, China. khliu@shou.edu.cn.
AD  - Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage 
      and Preservation (Shanghai), Ministry of Agriculture, Shanghai 201306, China. 
      khliu@shou.edu.cn.
FAU - Zhao, Yueliang
AU  - Zhao Y
AD  - College of Food Science and Technology, Shanghai Ocean University, No.999 
      Hu-Cheng-Huan Road, Shanghai 201306, China. ylzhao@shou.edu.cn.
FAU - Hu, Xiaoqian
AU  - Hu X
AD  - College of Food Science and Technology, Shanghai Ocean University, No.999 
      Hu-Cheng-Huan Road, Shanghai 201306, China. xqhu@shou.edu.cn.
AD  - Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage 
      and Preservation (Shanghai), Ministry of Agriculture, Shanghai 201306, China. 
      xqhu@shou.edu.cn.
FAU - Wang, Mingfu
AU  - Wang M
AD  - College of Food Science and Technology, Shanghai Ocean University, No.999 
      Hu-Cheng-Huan Road, Shanghai 201306, China. mfwang@hku.hk.
LA  - eng
PT  - Journal Article
DEP - 20180511
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (NF-kappa B)
RN  - 0 (Stilbenes)
RN  - 0 (Transcription Factor AP-1)
RN  - 26R60S6A5I (pterostilbene)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/chemistry/*pharmacology
MH  - Cell Survival/drug effects
MH  - Cytokines/genetics/metabolism
MH  - Inflammation/etiology/metabolism
MH  - Macrophages/*drug effects/metabolism
MH  - Mice
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - NF-kappa B/metabolism
MH  - Nitric Oxide/metabolism
MH  - Nitric Oxide Synthase Type II/metabolism
MH  - RAW 264.7 Cells
MH  - Resveratrol
MH  - Signal Transduction/drug effects
MH  - Stilbenes/chemistry/*pharmacology
MH  - Transcription Factor AP-1/metabolism
PMC - PMC6100408
OTO - NOTNLM
OT  - 4'-methoxyresveratrol
OT  - AP-1
OT  - MAPK
OT  - NF-kappaB
OT  - inflammation
OT  - pterostilbene
COIS- There is no conflict of interest.
EDAT- 2018/05/13 06:00
MHDA- 2018/09/27 06:00
PMCR- 2018/05/11
CRDT- 2018/05/13 06:00
PHST- 2018/04/11 00:00 [received]
PHST- 2018/05/02 00:00 [revised]
PHST- 2018/05/08 00:00 [accepted]
PHST- 2018/05/13 06:00 [entrez]
PHST- 2018/05/13 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PHST- 2018/05/11 00:00 [pmc-release]
AID - molecules23051148 [pii]
AID - molecules-23-01148 [pii]
AID - 10.3390/molecules23051148 [doi]
PST - epublish
SO  - Molecules. 2018 May 11;23(5):1148. doi: 10.3390/molecules23051148.