PMID- 29753427
OWN - NLM
STAT- MEDLINE
DCOM- 20190312
LR  - 20240229
IS  - 1399-0020 (Electronic)
IS  - 0901-5027 (Linking)
VI  - 47
IP  - 11
DP  - 2018 Nov
TI  - Gelfoam haemostatic agent with or without autologous bone marrow-derived stem 
      cells for the regeneration of critical-size mandibular defects in the rabbit.
PG  - 1488-1494
LID - S0901-5027(18)30152-8 [pii]
LID - 10.1016/j.ijom.2018.04.021 [doi]
AB  - This study evaluated the effect of Gelfoam sponge with and without autologous 
      bone marrow-derived stem cells (BMSCs) on bone regeneration in critical-size 
      mandibular defects. The study involved 56 New Zealand rabbits assigned to four 
      groups (14 in each). The osseous defects in group I were irrigated with normal 
      saline, those in group II were grafted with autogenous tibial bone, and those in 
      group III were filled with Gelfoam sponge. Group IV defects were treated as for 
      group III, but the interface between the Gelfoam sponge and bone surface was 
      injected with BMSCs. At the end of 4weeks, seven rabbits in each group were 
      euthanized; the remaining animals were euthanized at the end of the experiment, 
      at 8 weeks postoperative. The percentage area of newly formed bone was 
      significantly higher in group IV at week 4 (0.030+/-0.01%) and week 8 (0.060+/-0.03%) 
      than in group I (0.01+/-0.00% and 0.02+/-0.00%, respectively) and group III 
      (0.08+/-0.01% and 0.015+/-0.02%, respectively), but was lower than that in group II 
      (0.038+/-0.02% and 0.082+/-0.01%, respectively). Thus, the combination of Gelfoam and 
      autologous BMSCs promoted the regeneration of mandibular critical-size defects 
      better than the use of Gelfoam alone. However, the amount of newly generated bone 
      was lower than in defects grafted with autogenous bone.
CI  - Copyright (c) 2018 International Association of Oral and Maxillofacial Surgeons. 
      Published by Elsevier Ltd. All rights reserved.
FAU - Ashour, A A
AU  - Ashour AA
AD  - Ministry of Health, Faculty of Dentistry, Gharian University, Gharian, Libya.
FAU - Zaghloul, M
AU  - Zaghloul M
AD  - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mansoura 
      University, Mansoura, Egypt.
FAU - Mahmoud, W
AU  - Mahmoud W
AD  - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mansoura 
      University, Mansoura, Egypt.
FAU - Helal, M E
AU  - Helal ME
AD  - Department of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, 
      Egypt.
FAU - Grawish, M E
AU  - Grawish ME
AD  - Department of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, 
      Egypt; Department of Oral Biology, Faculty of Oral and Dental Medicine, Delta 
      University for Science and Technology, Gamasa, Mansoura, Egypt. Electronic 
      address: Grawish2005@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20180509
PL  - Denmark
TA  - Int J Oral Maxillofac Surg
JT  - International journal of oral and maxillofacial surgery
JID - 8605826
RN  - 0 (Hemostatics)
SB  - IM
MH  - Animals
MH  - Male
MH  - Rabbits
MH  - *Bone Marrow Cells/cytology
MH  - *Bone Regeneration/physiology
MH  - Cell Proliferation
MH  - Disease Models, Animal
MH  - *Gelatin Sponge, Absorbable/pharmacology
MH  - *Hemostatics/pharmacology
MH  - *Mandible/surgery
MH  - *Osteogenesis/physiology
MH  - Random Allocation
OTO - NOTNLM
OT  - Gelfoam sponge
OT  - autogenous bone
OT  - autologous bone marrow-derived stem cells
OT  - critical-size defect
OT  - rabbit mandible
EDAT- 2018/05/14 06:00
MHDA- 2019/03/12 06:00
CRDT- 2018/05/14 06:00
PHST- 2017/11/27 00:00 [received]
PHST- 2018/02/24 00:00 [revised]
PHST- 2018/04/20 00:00 [accepted]
PHST- 2018/05/14 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2018/05/14 06:00 [entrez]
AID - S0901-5027(18)30152-8 [pii]
AID - 10.1016/j.ijom.2018.04.021 [doi]
PST - ppublish
SO  - Int J Oral Maxillofac Surg. 2018 Nov;47(11):1488-1494. doi: 
      10.1016/j.ijom.2018.04.021. Epub 2018 May 9.