PMID- 29753576
OWN - NLM
STAT- MEDLINE
DCOM- 20190221
LR  - 20210525
IS  - 2255-534X (Electronic)
IS  - 2255-534X (Linking)
VI  - 83
IP  - 4
DP  - 2018 Oct-Dec
TI  - Is celiac disease better identified through HLA-DQ8 than through HLA-DQ2 in 
      Mexican subjects?
PG  - 410-413
LID - S0375-0906(18)30068-5 [pii]
LID - 10.1016/j.rgmx.2018.01.005 [doi]
AB  - INTRODUCTION AND AIMS: A strong genetic association between celiac disease (CD) 
      and the human leukocyte antigen (HLA) has been widely demonstrated. In Europe, 
      the HLA-DQ2 allele is predominant. However, studies in Latin America indicate 
      that HLA-DQ8 could be more frequent. In Mexico, the frequency of those alleles 
      has not been reported in subjects with CD. Therefore, the aim of the present 
      study was to evaluate the distribution of HLA-DQ2 and HLA-DQ8 in Mexican 
      individuals with CD. MATERIAL AND METHODS: An exploratory study was conducted on 
      a cohort of 49 subjects with chronic diarrhea. Autoantibodies for CD, duodenal 
      atrophy, and HLA haplotypes were determined. RESULTS: Thirty individuals had CD 
      (23 women, mean age 54.2 +/- 15.5 years), 24 (80%) of whom expressed HLA-DQ8, 15 
      (50%) expressed HLA-DQ2, and 11 (37%) presented with both alleles. However, 
      neither the HLA-DQ2 nor the HLA-DQ8 allele was found in 5 (10%) individuals. In 
      subjects with chronic diarrhea that did not have CD, 12 (63%) presented with 
      HLA-DQ2, and 7 (37%) with HLA-DQ8. Individuals with CD expressed the combinations 
      of the HLA-DQ8/DQ2 alleles (37 vs. 5%) and the HLA-DR4/DQ8 alleles (60 vs. 26%) 
      more frequently than the subjects without CD. CONCLUSIONS: In Mexican subjects 
      with CD, HLA-DQ8 distribution was more frequent than that of HLA-DQ2, indicating 
      a possible similarity to the frequency reported in other Latin American 
      countries. However, given the nature of the present study and its sample size, 
      further conclusions could not be reached.
CI  - Copyright (c) 2018 Asociacion Mexicana de Gastroenterologia. Publicado por Masson 
      Doyma Mexico S.A. All rights reserved.
FAU - Cerda-Contreras, E
AU  - Cerda-Contreras E
AD  - Departamento de Gastroenterologia, Instituto Nacional de Ciencias Medicas y 
      Nutricion <<Salvador Zubiran>>, Ciudad de Mexico, Mexico.
FAU - Ramirez-Cervantes, K L
AU  - Ramirez-Cervantes KL
AD  - Departamento de Gastroenterologia, Instituto Nacional de Ciencias Medicas y 
      Nutricion <<Salvador Zubiran>>, Ciudad de Mexico, Mexico.
FAU - Granados, J
AU  - Granados J
AD  - Departamento de Trasplantes, Instituto Nacional de Ciencias Medicas y Nutricion 
      <<Salvador Zubiran>>, Ciudad de Mexico, Mexico.
FAU - Mena, L
AU  - Mena L
AD  - Departamento de Trasplantes, Instituto Nacional de Ciencias Medicas y Nutricion 
      <<Salvador Zubiran>>, Ciudad de Mexico, Mexico.
FAU - Nunez-Alvarez, C
AU  - Nunez-Alvarez C
AD  - Departamento de Inmunologia, Instituto Nacional de Ciencias Medicas y Nutricion 
      <<Salvador Zubiran>>, Ciudad de Mexico, Mexico.
FAU - Uscanga, L
AU  - Uscanga L
AD  - Departamento de Gastroenterologia, Instituto Nacional de Ciencias Medicas y 
      Nutricion <<Salvador Zubiran>>, Ciudad de Mexico, Mexico; Departamento de 
      Trasplantes, Instituto Nacional de Ciencias Medicas y Nutricion <<Salvador 
      Zubiran>>, Ciudad de Mexico, Mexico; Departamento de Inmunologia, Instituto 
      Nacional de Ciencias Medicas y Nutricion <<Salvador Zubiran>>, Ciudad de Mexico, 
      Mexico. Electronic address: luis.uscangad@gmail.com.
LA  - eng
LA  - spa
PT  - Journal Article
TT  -  inverted question markEs posible una mejor identificacion de la enfermedad celiaca en sujetos 
      mexicanos por medio de HLA-DQ8 que de HLA-DQ2?
DEP - 20180509
PL  - Mexico
TA  - Rev Gastroenterol Mex (Engl Ed)
JT  - Revista de gastroenterologia de Mexico (English)
JID - 101778603
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DQ8 antigen)
SB  - IM
CIN - Rev Gastroenterol Mex. 2019 Jan - Mar;84(1):123-124. PMID: 30119968
MH  - Adult
MH  - Aged
MH  - Celiac Disease/*diagnosis
MH  - Cohort Studies
MH  - Diarrhea/etiology
MH  - Female
MH  - Genotype
MH  - HLA-DQ Antigens/*analysis
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Mexico
MH  - Middle Aged
OTO - NOTNLM
OT  - Celiac disease
OT  - Enfermedad celiaca
OT  - HLA-DQ2
OT  - HLA-DQ8
EDAT- 2018/05/14 06:00
MHDA- 2019/02/23 06:00
CRDT- 2018/05/14 06:00
PHST- 2017/05/24 00:00 [received]
PHST- 2018/01/03 00:00 [revised]
PHST- 2018/01/25 00:00 [accepted]
PHST- 2018/05/14 06:00 [pubmed]
PHST- 2019/02/23 06:00 [medline]
PHST- 2018/05/14 06:00 [entrez]
AID - S0375-0906(18)30068-5 [pii]
AID - 10.1016/j.rgmx.2018.01.005 [doi]
PST - ppublish
SO  - Rev Gastroenterol Mex (Engl Ed). 2018 Oct-Dec;83(4):410-413. doi: 
      10.1016/j.rgmx.2018.01.005. Epub 2018 May 9.