PMID- 29753727
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20191210
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 350
DP  - 2018 Sep 17
TI  - Gender-dependent changes in physical development, BDNF content and GSH redox 
      system in a model of acute neonatal hypoxia in rats.
PG  - 87-98
LID - S0166-4328(17)32030-2 [pii]
LID - 10.1016/j.bbr.2018.05.008 [doi]
AB  - Perinatal hypoxia-ischaemia is one of the leading factors that negatively 
      influence the development of the central nervous system. Our aim was to 
      investigate the effects of sex on the outcomes of acute neonatal hypoxia (ANH) in 
      rat pups. Male and female Wistar rats were exposed to a hypoxic condition (8% 
      oxygen for 120 min) at postnatal day 2 (P2). Immediately after ANH an increase in 
      HIF1-alpha gene expression was observed in the rat brains, independently of sex. 
      Brain-derived neurotrophic factor (BDNF) and glutathione peroxidase-4 gene 
      expression was increased in female animals only. Hypoxic pups of both sexes 
      showed a decreased reduced/oxidised glutathione (GSH/GSSG) ratio in the blood and 
      only males had an increased GSH content in the whole brain immediately after 
      hypoxia. Furthermore, an increased BDNF content in the brain was found in both 
      male and female rat pups at 0 h and in serum 4 h after hypoxia, but at 4 h after 
      hypoxia only males had an increased BDNF level in the brain. Only hypoxic males 
      displayed retarded performance in the righting reflex, but in a negative geotaxis 
      test hypoxic pups of both sexes had an increased turnaround time. Moreover, 
      hypoxic female but not male pups demonstrated less weight gain than control 
      littermates for the entire observation period (until P18). These results 
      demonstrate that ANH at P2 leads to both molecular and physiological impairments 
      in a sex-specific manner and the described model could be used to represent mild 
      hypoxic brain damage in very preterm infants.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Sukhanova, Iu A
AU  - Sukhanova IA
AD  - Lomonosov Moscow State University, Biology Faculty, Moscow, Russia; Federal State 
      Budget Institution 'Research Centre for Obstetrics Gynaecology and Perinatology' 
      Ministry of Healthcare and Social Development of the Russian Federation, Moscow, 
      Russia. Electronic address: sukhanova.iuliia.2014@post.bio.msu.ru.
FAU - Sebentsova, E A
AU  - Sebentsova EA
AD  - Institute of Molecular Genetics, Russian Academy of Science, Moscow, Russia.
FAU - Khukhareva, D D
AU  - Khukhareva DD
AD  - Lomonosov Moscow State University, Biology Faculty, Moscow, Russia.
FAU - Manchenko, D M
AU  - Manchenko DM
AD  - Lomonosov Moscow State University, Biology Faculty, Moscow, Russia.
FAU - Glazova, N Yu
AU  - Glazova NY
AD  - Institute of Molecular Genetics, Russian Academy of Science, Moscow, Russia.
FAU - Vishnyakova, P A
AU  - Vishnyakova PA
AD  - Federal State Budget Institution 'Research Centre for Obstetrics Gynaecology and 
      Perinatology' Ministry of Healthcare and Social Development of the Russian 
      Federation, Moscow, Russia.
FAU - Inozemtseva, L S
AU  - Inozemtseva LS
AD  - Institute of Molecular Genetics, Russian Academy of Science, Moscow, Russia.
FAU - Dolotov, O V
AU  - Dolotov OV
AD  - Institute of Molecular Genetics, Russian Academy of Science, Moscow, Russia.
FAU - Vysokikh, M Y
AU  - Vysokikh MY
AD  - Federal State Budget Institution 'Research Centre for Obstetrics Gynaecology and 
      Perinatology' Ministry of Healthcare and Social Development of the Russian 
      Federation, Moscow, Russia.
FAU - Levitskaya, N G
AU  - Levitskaya NG
AD  - Lomonosov Moscow State University, Biology Faculty, Moscow, Russia; Institute of 
      Molecular Genetics, Russian Academy of Science, Moscow, Russia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180516
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Hif1a protein, rat)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (RNA, Messenger)
RN  - EC 1.11.1.12 (Phospholipid Hydroperoxide Glutathione Peroxidase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.11.1.9 (glutathione peroxidase 4, rat)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/growth & development/metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Female
MH  - Glutathione/*metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
MH  - Hypoxia-Ischemia, Brain/pathology/*physiopathology
MH  - Male
MH  - Phospholipid Hydroperoxide Glutathione Peroxidase
MH  - RNA, Messenger/metabolism
MH  - Random Allocation
MH  - Rats, Wistar
MH  - *Sex Characteristics
OTO - NOTNLM
OT  - Animal model
OT  - Brain-derived neurotrophic factor
OT  - Glutathione
OT  - Motor development
OT  - Neonatal hypoxia
OT  - Sexual dimorphism
EDAT- 2018/05/14 06:00
MHDA- 2018/11/27 06:00
CRDT- 2018/05/14 06:00
PHST- 2017/12/28 00:00 [received]
PHST- 2018/04/17 00:00 [revised]
PHST- 2018/05/08 00:00 [accepted]
PHST- 2018/05/14 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2018/05/14 06:00 [entrez]
AID - S0166-4328(17)32030-2 [pii]
AID - 10.1016/j.bbr.2018.05.008 [doi]
PST - ppublish
SO  - Behav Brain Res. 2018 Sep 17;350:87-98. doi: 10.1016/j.bbr.2018.05.008. Epub 2018 
      May 16.