PMID- 29754397
OWN - NLM
STAT- MEDLINE
DCOM- 20190315
LR  - 20220409
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 25
IP  - 8
DP  - 2018 Aug
TI  - Blink reflex recovery cycle to differentiate progressive supranuclear palsy from 
      corticobasal syndrome.
PG  - 1100-e85
LID - 10.1111/ene.13673 [doi]
AB  - BACKGROUND AND PURPOSE: Progressive supranuclear palsy (PSP) and corticobasal 
      syndrome (CBS) may share similar clinical findings and tests to distinguish 
      between the two disorders could be useful. We evaluated the blink reflex and R2 
      blink reflex recovery cycle (R2BRRC), determining diagnostic sensitivity, 
      specificity and positive and negative predictive value of R2BRRC in 
      differentiating patients with PSP from those with CBS. METHODS: This was a 
      prospective data collection study investigating blink reflex and R2BRRC at 
      interstimulus intervals (ISIs) of 100, 150, 200, 300, 400, 500 and 750 ms in 12 
      patients with PSP, eight patients with CBS and 10 controls. RESULTS: Patients 
      with PSP have earlier recruitment of R2BRRC as compared with patients with CBS 
      (ISI: 100 ms, P = 0.002; 150 ms, P < 0.001; 200 ms, P < 0.001; 300 ms, P = 0.02) 
      and controls (ISI: 100 ms, P < 0.001; 150 ms, P < 0.001; 200 ms, P < 0.001; 300 
      ms, P = 0.004). The presence of an early recovery of the R2 differentiated PSP 
      from CBS with a specificity and sensitivity of 87.5% and 91.7%, respectively. 
      CONCLUSIONS: The R2BRRC curve might be considered to be a useful tool in 
      differentiating patients with PSP from those with CBS.
CI  - (c) 2018 EAN.
FAU - Sciacca, G
AU  - Sciacca G
AUID- ORCID: 0000-0002-1629-1282
AD  - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, 
      University of Catania, Catania, Italy.
FAU - Nicoletti, A
AU  - Nicoletti A
AD  - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, 
      University of Catania, Catania, Italy.
FAU - Mostile, G
AU  - Mostile G
AD  - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, 
      University of Catania, Catania, Italy.
FAU - Luca, A
AU  - Luca A
AD  - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, 
      University of Catania, Catania, Italy.
FAU - Raciti, L
AU  - Raciti L
AD  - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, 
      University of Catania, Catania, Italy.
FAU - Dibilio, V
AU  - Dibilio V
AD  - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, 
      University of Catania, Catania, Italy.
FAU - Drago, F
AU  - Drago F
AD  - Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, 
      University of Catania, Catania, Italy.
FAU - Salomone, S
AU  - Salomone S
AD  - Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, 
      University of Catania, Catania, Italy.
FAU - Zappia, M
AU  - Zappia M
AD  - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, 
      University of Catania, Catania, Italy.
LA  - eng
PT  - Journal Article
DEP - 20180612
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
SB  - IM
CIN - Eur J Neurol. 2020 Nov;27(11):e68. PMID: 32526800
CIN - Eur J Neurol. 2020 Nov;27(11):e74. PMID: 32618054
MH  - Aged
MH  - Aged, 80 and over
MH  - *Blinking
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Male
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Sensitivity and Specificity
MH  - Supranuclear Palsy, Progressive/*diagnosis
MH  - Syndrome
OTO - NOTNLM
OT  - blink reflex recovery cycle
OT  - corticobasal syndrome
OT  - progressive supranuclear palsy
EDAT- 2018/05/14 06:00
MHDA- 2019/03/16 06:00
CRDT- 2018/05/14 06:00
PHST- 2018/02/04 00:00 [received]
PHST- 2018/05/03 00:00 [accepted]
PHST- 2018/05/14 06:00 [pubmed]
PHST- 2019/03/16 06:00 [medline]
PHST- 2018/05/14 06:00 [entrez]
AID - 10.1111/ene.13673 [doi]
PST - ppublish
SO  - Eur J Neurol. 2018 Aug;25(8):1100-e85. doi: 10.1111/ene.13673. Epub 2018 Jun 12.