PMID- 29754693
OWN - NLM
STAT- MEDLINE
DCOM- 20190820
LR  - 20190820
IS  - 1552-6259 (Electronic)
IS  - 0003-4975 (Linking)
VI  - 106
IP  - 2
DP  - 2018 Aug
TI  - Preoperative 6-Minute Walk Distance Is Associated With Postoperative Cognitive 
      Dysfunction.
PG  - 505-512
LID - S0003-4975(18)30438-7 [pii]
LID - 10.1016/j.athoracsur.2018.03.010 [doi]
AB  - BACKGROUND: Postoperative cognitive dysfunction (POCD) is a neurologic 
      dysfunction that occurs after surgery. POCD persists for a long period, ranging 
      from weeks to months, and affects a patient's quality of life. A 6-minute walk 
      distance (6MWD) has been used to predict postoperative complications after 
      several operations. The present study investigated whether there was an 
      independent association of a low preoperative 6MWD with POCD in patients who 
      underwent cardiac operations. METHODS: The study included 181 patients who 
      underwent a cardiac operation. The 6MWD was performed prospectively on admission 
      for the operation. POCD was defined as a decrease of 2 points or more in a 
      patient's Mini-Mental State Examination score. POCD developed in 51 (28%) of 
      these patients. Patients were categorized into a POCD or a non-POCD group, and 
      the perioperative variables were compared between the groups. Multivariable 
      logistic regression analysis was performed to identify risk factors for the 
      development of POCD. RESULTS: The patients were a mean age of 71.4 years. The 
      POCD group showed a significantly lower 6MWD (median, 400 m) than the non-POCD 
      group (median, 450 m). The 6MWD, intensive care unit length of stay, age, and 
      Mini-Mental State Examination score were identified as independent risk factors 
      for POCD by multivariable analysis. The odds ratio for each increase of 50 m in 
      the 6MWD was 0.807 for POCD. CONCLUSIONS: The 6MWD is useful in identifying 
      patients with a higher chance of developing POCD after a cardiac operation.
CI  - Copyright (c) 2018 The Society of Thoracic Surgeons. Published by Elsevier Inc. All 
      rights reserved.
FAU - Hayashi, Kazuhiro
AU  - Hayashi K
AD  - Department of Rehabilitation, Nagoya University Hospital, Nagoya, Japan; 
      Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan; 
      Department of Rehabilitation, Aichi Medical University, Nagakute, Japan. 
      Electronic address: hayashi.kzhr@gmail.com.
FAU - Oshima, Hideki
AU  - Oshima H
AD  - Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Shimizu, Miho
AU  - Shimizu M
AD  - Department of Rehabilitation, Nagoya University Hospital, Nagoya, Japan.
FAU - Kobayashi, Kiyonori
AU  - Kobayashi K
AD  - Department of Rehabilitation, Nagoya University Hospital, Nagoya, Japan.
FAU - Matsui, Shigeyuki
AU  - Matsui S
AD  - Department of Biostatics, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Nishida, Yoshihiro
AU  - Nishida Y
AD  - Department of Rehabilitation, Nagoya University Hospital, Nagoya, Japan; 
      Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Usui, Akihiko
AU  - Usui A
AD  - Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180510
PL  - Netherlands
TA  - Ann Thorac Surg
JT  - The Annals of thoracic surgery
JID - 15030100R
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Cardiac Surgical Procedures/*adverse effects/*methods
MH  - Cognitive Dysfunction/epidemiology/etiology/*physiopathology
MH  - Cohort Studies
MH  - Exercise Test/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Postoperative Complications/epidemiology/physiopathology
MH  - Preoperative Care/methods
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Sex Factors
MH  - *Walking
EDAT- 2018/05/15 06:00
MHDA- 2019/08/21 06:00
CRDT- 2018/05/15 06:00
PHST- 2017/08/05 00:00 [received]
PHST- 2018/02/18 00:00 [revised]
PHST- 2018/03/05 00:00 [accepted]
PHST- 2018/05/15 06:00 [pubmed]
PHST- 2019/08/21 06:00 [medline]
PHST- 2018/05/15 06:00 [entrez]
AID - S0003-4975(18)30438-7 [pii]
AID - 10.1016/j.athoracsur.2018.03.010 [doi]
PST - ppublish
SO  - Ann Thorac Surg. 2018 Aug;106(2):505-512. doi: 10.1016/j.athoracsur.2018.03.010. 
      Epub 2018 May 10.