PMID- 29755605
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220317
IS  - 1874-3129 (Print)
IS  - 1874-3129 (Electronic)
IS  - 1874-3129 (Linking)
VI  - 12
DP  - 2018
TI  - The Prevalence of Osteopenia and Osteoporosis Among Malaysian Type 2 Diabetic 
      Patients Using Quantitative Ultrasound Densitometer.
PG  - 50-64
LID - 10.2174/1874312901812010050 [doi]
AB  - BACKGROUND: Type 2 Diabetes Mellitus (T2DM) and osteoporosis are both chronic 
      conditions and the relationship between them is complex. OBJECTIVE: The aims of 
      this study were to assess the prevalence of Low Bone Mineral density (LBMD, i.e., 
      osteopenia and osteoporosis), as well as, the difference and associations between 
      Quantitative Ultrasound Scan (QUS) parameters with socio-demographic data and 
      clinical related data among T2DM in Penang, Malaysia. METHOD: An observational, 
      cross-sectional study with a convenient sample of 450 T2DM patients were 
      recruited from the outpatient diabetes clinic at Hospital Pulau Pinang (HPP) to 
      measure Bone Mineral Density (BMD) at the heel bone using QUS. In addition, a 
      self-reported structured questionnaire about the socio-demographic data and 
      osteoporosis risk factors were collected. Moreover, the study included the 
      retrospective collection of clinical data from patients' medical records. 
      RESULTS: The mean value of T-score for normal BMD, osteopenic and osteoporotic 
      patients' were (-0.41+/-0.44), (-1.65+/-0.39) and (-2.76+/-0.27), respectively. 
      According to QUS measurements, more than three quarters of T2DM patients (82%) 
      were at high risk of abnormal BMD. The results showed that QUS scores were 
      significantly associated with age, gender, menopausal duration, educational level 
      and diabetic related data. Moreover, the QUS parameters and T-scores demonstrated 
      significant negative correlation with age, menopausal duration, diabetic duration 
      and glycaemic control, as well as, a positive correlation with body mass index 
      and waist to hip ratio. The current study revealed that none of the 
      cardiovascular disease risk factors appear to influence the prevalence of low BMD 
      among T2DM Malaysian patients. CONCLUSION: The study findings revealed that the 
      assessment of T2DM patients' bone health and related factor are essential and 
      future educational programs are crucial to improve osteoporosis management.
FAU - Abdulameer, Shaymaa Abdalwahed
AU  - Abdulameer SA
AD  - Faculty of Pharmacy, Al-Rafidain University College, Palestine Street, 10052, 
      Baghdad, Iraq.
FAU - Sahib, Mohanad Naji
AU  - Sahib MN
AD  - Faculty of Pharmacy, Al-Rafidain University College, Palestine Street, 10052, 
      Baghdad, Iraq.
FAU - Sulaiman, Syed Azhar Syed
AU  - Sulaiman SAS
AD  - School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, 11800, 
      Penang, Malaysia.
LA  - eng
PT  - Journal Article
DEP - 20180425
PL  - United Arab Emirates
TA  - Open Rheumatol J
JT  - The open rheumatology journal
JID - 101480507
PMC - PMC5925862
OTO - NOTNLM
OT  - Diabetes
OT  - Malaysia
OT  - Osteopenia
OT  - Osteoporosis
OT  - Prevalence
OT  - Quantitative ultrasound
EDAT- 2018/05/15 06:00
MHDA- 2018/05/15 06:01
PMCR- 2018/01/01
CRDT- 2018/05/15 06:00
PHST- 2017/12/30 00:00 [received]
PHST- 2018/03/06 00:00 [revised]
PHST- 2018/03/30 00:00 [accepted]
PHST- 2018/05/15 06:00 [entrez]
PHST- 2018/05/15 06:00 [pubmed]
PHST- 2018/05/15 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - TORJ-12-50 [pii]
AID - 10.2174/1874312901812010050 [doi]
PST - epublish
SO  - Open Rheumatol J. 2018 Apr 25;12:50-64. doi: 10.2174/1874312901812010050. 
      eCollection 2018.