PMID- 29755818
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 2149-8695 (Print)
IS  - 2149-8709 (Electronic)
IS  - 2149-8709 (Linking)
VI  - 48
IP  - 2
DP  - 2018 Apr
TI  - Retinal Angiomatous Proliferation: Multimodal Imaging Characteristics and 
      Follow-up with Eye-Tracked Spectral Domain Optical Coherence Tomography of 
      Precursor Lesions.
PG  - 66-69
LID - 10.4274/tjo.03780 [doi]
AB  - OBJECTIVES: To present the multimodal imaging characteristics of precursor 
      retinal angiomatous proliferation (RAP) lesions and follow-up results with 
      eye-tracked spectral-domain optical coherence tomography (SD-OCT). MATERIALS AND 
      METHODS: Six eyes of 6 patients aged 77.5+/-5.9 years diagnosed with precursor RAP 
      lesion were included in this prospective observational case series. Best 
      corrected visual acuity (BCVA) measurement and complete ophthalmologic 
      examination were performed for all subjects, as well as fundus photography (FP), 
      fundus autofluorescence (FAF), SD-OCT, fluorescein angiography (FA), indocyanine 
      green angiography (ICGA), optical coherence tomography angiography (OCTA), and 
      their long-term follow-up results are presented. RESULTS: The mean BCVA was 
      0.8+/-0.16 (0.6-1) Snellen and the mean follow-up was 26.3+/-14.8 months. Images of 
      the precursor RAP lesions demonstrated no specific findings on FP and FAF, showed 
      focal hypofluorescent foci with no leakage on FA and IGA, and appeared as 
      extrafoveal small, round, well-defined, hyperreflective foci typically located in 
      the outer retinal layers on SD-OCT B-scans with high sampling density. OCTA 
      demonstrated the precursor lesions as the deep capillary plexus abnormalities in 
      3 eyes. Two eyes progressed to stage 1 RAP during the follow-up period. 
      CONCLUSION: This study defined the diagnostic characteristics and clinical course 
      of precursor RAP lesions. Our findings highlight the importance of B-scans with 
      high sampling density for the diagnosis of precursor lesions and using 
      eye-tracking mode SD-OCT during follow-up.
FAU - Oztas, Zafer
AU  - Oztas Z
AUID- ORCID: 0000-0001-8367-7399
AD  - Ege University Faculty of Medicine, Department of Ophthalmology, Izmir, Turkey.
FAU - Mentes, Jale
AU  - Mentes J
AUID- ORCID: 0000-0003-3275-1127
AD  - Ege University Faculty of Medicine, Department of Ophthalmology, Izmir, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20180425
PL  - Turkey
TA  - Turk J Ophthalmol
JT  - Turkish journal of ophthalmology
JID - 101686048
PMC - PMC5938478
OTO - NOTNLM
OT  - Retinal angiomatous proliferation
OT  - spectral-domain optical coherence tomography
OT  - type 3 neovascularization
COIS- Conflict of Interest: No conflict of interest was declared by the authors.
EDAT- 2018/05/15 06:00
MHDA- 2018/05/15 06:01
PMCR- 2018/04/01
CRDT- 2018/05/15 06:00
PHST- 2017/03/27 00:00 [received]
PHST- 2017/09/11 00:00 [accepted]
PHST- 2018/05/15 06:00 [entrez]
PHST- 2018/05/15 06:00 [pubmed]
PHST- 2018/05/15 06:01 [medline]
PHST- 2018/04/01 00:00 [pmc-release]
AID - 17057 [pii]
AID - 10.4274/tjo.03780 [doi]
PST - ppublish
SO  - Turk J Ophthalmol. 2018 Apr;48(2):66-69. doi: 10.4274/tjo.03780. Epub 2018 Apr 
      25.