PMID- 29756237
OWN - NLM
STAT- MEDLINE
DCOM- 20180925
LR  - 20200930
IS  - 1521-4095 (Electronic)
IS  - 0935-9648 (Linking)
VI  - 30
IP  - 31
DP  - 2018 Aug
TI  - Biopolymers for Antitumor Implantable Drug Delivery Systems: Recent Advances and 
      Future Outlook.
PG  - e1706665
LID - 10.1002/adma.201706665 [doi]
AB  - In spite of remarkable improvements in cancer treatments and survivorship, cancer 
      still remains as one of the major causes of death worldwide. Although current 
      standards of care provide encouraging results, they still cause severe systemic 
      toxicity and also fail in preventing recurrence of the disease. In order to 
      address these issues, biomaterial-based implantable drug delivery systems (DDSs) 
      have emerged as promising therapeutic platforms, which allow local administration 
      of drugs directly to the tumor site. Owing to the unique properties of 
      biopolymers, they have been used in a variety of ways to institute biodegradable 
      implantable DDSs that exert precise spatiotemporal control over the release of 
      therapeutic drug. Here, the most recent advances in biopolymer-based DDSs for 
      suppressing tumor growth and preventing tumor recurrence are reviewed. Novel 
      emerging biopolymers as well as cutting-edge polymeric microdevices deployed as 
      implantable antitumor DDSs are discussed. Finally, a review of a new therapeutic 
      modality within the field, which is based on implantable biopolymeric DDSs, is 
      given.
CI  - (c) 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Talebian, Sepehr
AU  - Talebian S
AD  - Intelligent Polymer Research Institute, ARC Centre of Excellence for 
      Electromaterials Science, AIIM Facility, University of Wollongong, NSW 2522, 
      Australia.
AD  - Illawarra Health and Medical Research Institute, University of Wollongong, 
      Wollongong, NSW, 2522, Australia.
FAU - Foroughi, Javad
AU  - Foroughi J
AD  - Intelligent Polymer Research Institute, ARC Centre of Excellence for 
      Electromaterials Science, AIIM Facility, University of Wollongong, NSW 2522, 
      Australia.
AD  - Illawarra Health and Medical Research Institute, University of Wollongong, 
      Wollongong, NSW, 2522, Australia.
FAU - Wade, Samantha J
AU  - Wade SJ
AD  - Illawarra Health and Medical Research Institute, University of Wollongong, 
      Wollongong, NSW, 2522, Australia.
AD  - School of Biological Sciences, University of Wollongong, NSW 2522, Australia.
FAU - Vine, Kara L
AU  - Vine KL
AD  - Illawarra Health and Medical Research Institute, University of Wollongong, 
      Wollongong, NSW, 2522, Australia.
AD  - School of Biological Sciences, Centre for Medical and Molecular Bioscience, 
      University of Wollongong, NSW 2522, Australia.
FAU - Dolatshahi-Pirouz, Alireza
AU  - Dolatshahi-Pirouz A
AD  - Technical University of Denmark, DTU Nanotech, Center for Nanomedicine and 
      Theranostics, 2800 Kongens Lyngby, Denmark.
FAU - Mehrali, Mehdi
AU  - Mehrali M
AD  - Technical University of Denmark, DTU Nanotech, Center for Nanomedicine and 
      Theranostics, 2800 Kongens Lyngby, Denmark.
FAU - Conde, Joao
AU  - Conde J
AD  - Massachusetts Institute of Technology, Institute for Medical Engineering and 
      Science, Harvard-MIT Division for Health Sciences and Technology, Cambridge, MA, 
      02139, USA.
FAU - Wallace, Gordon G
AU  - Wallace GG
AUID- ORCID: 0000-0002-0381-7273
AD  - Intelligent Polymer Research Institute, ARC Centre of Excellence for 
      Electromaterials Science, AIIM Facility, University of Wollongong, NSW 2522, 
      Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180513
PL  - Germany
TA  - Adv Mater
JT  - Advanced materials (Deerfield Beach, Fla.)
JID - 9885358
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Biopolymers)
RN  - 0 (Drug Carriers)
RN  - 0 (RNA, Small Interfering)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*chemistry/therapeutic use
MH  - Biocompatible Materials/chemistry
MH  - Biopolymers/*chemistry
MH  - Drug Carriers/*chemistry
MH  - Humans
MH  - Neoplasms/drug therapy
MH  - Printing, Three-Dimensional
MH  - Prostheses and Implants
MH  - RNA, Small Interfering/chemistry/therapeutic use
OTO - NOTNLM
OT  - 3D printing
OT  - biopolymers
OT  - cancer
OT  - drug delivery
OT  - electrospinning
OT  - implants
OT  - injectable gels
EDAT- 2018/05/15 06:00
MHDA- 2018/09/27 06:00
CRDT- 2018/05/15 06:00
PHST- 2017/11/14 00:00 [received]
PHST- 2018/02/15 00:00 [revised]
PHST- 2018/05/15 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PHST- 2018/05/15 06:00 [entrez]
AID - 10.1002/adma.201706665 [doi]
PST - ppublish
SO  - Adv Mater. 2018 Aug;30(31):e1706665. doi: 10.1002/adma.201706665. Epub 2018 May 
      13.