PMID- 29756703
OWN - NLM
STAT- MEDLINE
DCOM- 20190828
LR  - 20190828
IS  - 1668-3501 (Electronic)
IS  - 0325-0075 (Linking)
VI  - 116
IP  - 3
DP  - 2018 Jun 1
TI  - Most commonly isolated viruses in asthma exacerbation and their correlation with 
      eosinophil and total serum immunoglobulin E levels.
PG  - 192-197
LID - 10.5546/aap.2018.eng.192 [doi]
AB  - BACKGROUND: Asthma exacerbations are still a cause of hospitalization at the 
      Emergency Department. The triggers of asthma exacerbations include allergens and 
      infections -mostly viral-. The objective of this study was to establish the 
      relationship between viruses detected during an asthma exacerbation and 
      eosinophil and serum immunoglobulin E (IgE) levels in pediatric patients. 
      POPULATION AND METHODS: Cross-sectional. analytical study. Children aged 5-15 
      years seen at the Pediatric Emergency Department with an asthma exacerbation in 
      the period between March 2013 and February 2016 were included. Viral ribonucleic 
      acid was extracted from nasopharyngeal aspirates using the CLART Pneumo Vir kit. 
      Eosinophil levels were measured in peripheral blood and total IgE levels, in 
      serum. Eosinophilia was defined as a count >/= 0.4 x 103/ mm3 and high IgE. as a 
      level >/= 350 IU/L. The Pearson's correlation was carried out. A value of p </= 0.05 
      was considered significant. RESULTS: Out of 211 children with asthma 
      exacerbation, a virus was isolated in 20%. The most commonly isolated viruses 
      were rhinovirus. enterovirus, and respiratory syncytial virus. A correlation of 
      0.89 was established between eosinophil and total serum IgE levels in children 
      with asthma exacerbation and rhinovirus, with a p value of 0.0001. CONCLUSIONS: 
      Rhinovirus, enterovirus, and respiratory syncytial virus were the most common 
      viruses in asthma exacerbations in children younger than 15 years. A correlation 
      was established between eosinophil and IgE levels in the presence of rhinovirus.
CI  - Sociedad Argentina de Pediatria.
FAU - Robledo Aceves, Mireya
AU  - Robledo Aceves M
AD  - Departamento de Urgencias de Pediatria, Hospital Civil de Guadalajara Dr. Juan I. 
      Menchaca, Jalisco, Mexico. myreace@yahoo.es.
FAU - Barron Balderas, Alejandro
AU  - Barron Balderas A
AD  - Departamento de Urgencias de Pediatria, Hospital Civil de Guadalajara Dr. Juan I. 
      Menchaca, Jalisco, Mexico.
FAU - Jaime Ornelas, Maria de L
AU  - Jaime Ornelas ML
AD  - Departamento de Pediatria, Hospital Civil de Guadalajara Dr. Juan I. Menchaca, 
      Jalisco, Mexico.
LA  - eng
LA  - spa
PT  - Journal Article
TT  - Virus mas frecuentemente aislados en la exacerbacion de asma y su correlacion con 
      niveles de eosinofilos e inmunoglobulina E serica total.
PL  - Argentina
TA  - Arch Argent Pediatr
JT  - Archivos argentinos de pediatria
JID - 0372460
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Asthma/blood/physiopathology/*virology
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Emergency Service, Hospital
MH  - Enterovirus/isolation & purification
MH  - Enterovirus Infections/diagnosis/epidemiology
MH  - Eosinophils/*metabolism
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Picornaviridae Infections/diagnosis/epidemiology
MH  - Respiratory Syncytial Virus Infections/diagnosis/epidemiology
MH  - Respiratory Syncytial Virus, Human/isolation & purification
MH  - Rhinovirus/isolation & purification
OTO - NOTNLM
OT  - asthma
OT  - eosinophils
OT  - immunoglobulin E
OT  - rhinovirus
EDAT- 2018/05/15 06:00
MHDA- 2019/08/29 06:00
CRDT- 2018/05/15 06:00
PHST- 2017/04/26 00:00 [received]
PHST- 2017/10/12 00:00 [accepted]
PHST- 2018/05/15 06:00 [entrez]
PHST- 2018/05/15 06:00 [pubmed]
PHST- 2019/08/29 06:00 [medline]
AID - 10.5546/aap.2018.eng.192 [doi]
PST - ppublish
SO  - Arch Argent Pediatr. 2018 Jun 1;116(3):192-197. doi: 10.5546/aap.2018.eng.192.