PMID- 29757551
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 32
IP  - 2
DP  - 2018 Jan 20
TI  - [Expression and clinical significance of long non-coding RNA LINC00520 in 
      laryngeal squamous cell carcinoma].
PG  - 91-95
LID - 10.13201/j.issn.1001-1781.2018.02.003 [doi]
AB  - Objective:To investigate the expression of LINC00520 in laryngeal squamous cell 
      carcinoma(LSCC),and analyze its relevance and roles in carcinogenesis and 
      development of LSCC.Method:The expression of LINC00520 in laryngeal squamous cell 
      carcinoma tissue and paired adjacent normal tissue was determined by real-time 
      PCR.The relationship between the expression of LINC00520 and the 
      clinicopathological characteristics including clinical stage,pathological 
      type,histological grade and lymph node metastasis of LSCC was 
      analyzed.Result:(1)The LINC00520 expression level was significantly upregulated 
      in LSCC tissues compared to that of paired adjacent normal tissues(P<0.000 
      1).(2)There were no statistical differences of the LINC00520 expression level 
      among supraglottic,glottic and subglottic LSCCs(P>0.05).The LINC00520 expression 
      level had no significant changes in poorly differentiated LSCC compared with that 
      of well and moderately differentiated counterparts(P>0.05).Moreover,the 
      expression of LINC00520 had no significant difference between T1+T2 stage and 
      T3+T4 stage LSCC tissues(P>0.05).Interestingly,the LINC00520 level in LSCC with 
      lymph node metastasis was significantly higher than that in patients without 
      lymph node metastasis(P<0.01).Conclusion:Upregulation of LINC00520 in LSCC may 
      contribute to its metastasis.
FAU - Wu, Yong Yan
AU  - Wu YY
AD  - Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of 
      Shanxi Medical University Taiyuan,030001,China.
FAU - Gao, Wei
AU  - Gao W
AD  - Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of 
      Shanxi Medical University Taiyuan,030001,China.
FAU - Zhang, Yu Liang
AU  - Zhang YL
AD  - Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of 
      Shanxi Medical University Taiyuan,030001,China.
FAU - Niu, Min
AU  - Niu M
AD  - Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of 
      Shanxi Medical University Taiyuan,030001,China.
FAU - Cui, Jia Jia
AU  - Cui JJ
AD  - Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of 
      Shanxi Medical University Taiyuan,030001,China.
FAU - Xiang, Cai Xia
AU  - Xiang CX
AD  - Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of 
      Shanxi Medical University Taiyuan,030001,China.
FAU - Sang, Jiang Wei
AU  - Sang JW
AD  - Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of 
      Shanxi Medical University Taiyuan,030001,China.
FAU - Wen, Shu Xin
AU  - Wen SX
AD  - Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of 
      Shanxi Medical University Taiyuan,030001,China.
FAU - Wang, Bin Quan
AU  - Wang BQ
AD  - Department of Otorhinolaryngology Head and Neck Surgery,the First Hospital of 
      Shanxi Medical University Taiyuan,030001,China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - *Lymphatic Metastasis
MH  - Prognosis
MH  - RNA, Long Noncoding/*metabolism
MH  - Up-Regulation
OTO - NOTNLM
OT  - LINC00520
OT  - laryngeal neoplasms
OT  - long non-coding RNA
OT  - tumor metastasis
EDAT- 2018/05/15 06:00
MHDA- 2018/05/15 06:01
CRDT- 2018/05/15 06:00
PHST- 2017/11/12 00:00 [received]
PHST- 2018/05/15 06:00 [entrez]
PHST- 2018/05/15 06:00 [pubmed]
PHST- 2018/05/15 06:01 [medline]
AID - 10.13201/j.issn.1001-1781.2018.02.003 [doi]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Jan 20;32(2):91-95. doi: 
      10.13201/j.issn.1001-1781.2018.02.003.