PMID- 29759576
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210402
IS  - 2405-5018 (Electronic)
IS  - 2405-500X (Linking)
VI  - 2
IP  - 5
DP  - 2016 Oct
TI  - Time Dependence of Ventricular Tachyarrhythmias After Myocardial Infarction: A 
      MADIT-CRT Substudy.
PG  - 565-573
LID - S2405-500X(16)30112-8 [pii]
LID - 10.1016/j.jacep.2016.04.010 [doi]
AB  - OBJECTIVES: The purpose of this study was to assess the relationship between the 
      time since a myocardial infarction (MI) and the risk of ventricular 
      tachyarrhythmic events (VTEs) in patients with left ventricular dysfunction and 
      mild symptoms of heart failure. BACKGROUND: Patients with left ventricular 
      dysfunction after MI are at high risk for VTEs. METHODS: Ventricular tachycardia 
      (VT), ventricular fibrillation (VF), or death as a function of time since MI was 
      assessed in 693 patients enrolled in the MADIT-CRT (Multicenter Automatic 
      Defibrillator Implantation Trial-Cardiac Resynchronization Therapy). Patients 
      were categorized as those with a period of <3 years since an MI (lowest quartile, 
      n = 172) versus those with a period of >/=3 years since an MI (n = 521). Risk of 
      VT/VF or death was compared. RESULTS: Cumulative probability of VT/VF or death 
      was significantly higher among patients in the highest quartile of time since an 
      MI compared with those in the lowest quartile (41% vs. 22%, p = 0.015). 
      Multivariate analysis showed that in patients with left bundle branch block 
      (LBBB), those with a period of >/=3 years since an MI had a significantly higher 
      risk of VT/VF or death (hazard ratio: 2.33; 95% confidence interval: 1.43 to 
      3.80; p = 0.001) and a higher risk of VT/VF (hazard ratio: 3.18; 95% confidence 
      interval: 1.71 to 5.90; p < 0.001) compared with patients with a period of <3 
      years since an MI. These findings were consistent when the time since an MI was 
      analyzed in a continuous fashion. A significant relationship between the time 
      since an MI and outcomes was not observed in patients with non-LBBB. CONCLUSIONS: 
      Among post-MI patients with left ventricular dysfunction and LBBB, the risk of 
      VTEs is directly related to the time since an MI occurred. (Multicenter Automatic 
      Defibrillator Implantation Trial-Cardiac Resynchronization Therapy [MADIT-CRT]; 
      NCT00180271).
CI  - Copyright (c) 2016 American College of Cardiology Foundation. Published by Elsevier 
      Inc. All rights reserved.
FAU - Ozlu, Mehmet F
AU  - Ozlu MF
AD  - Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey.
FAU - Barsheshet, Alon
AU  - Barsheshet A
AD  - Cardiology Department, Rabin Medical Center, Petah Tikva, and Sackler Faculty of 
      Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Moss, Arthur J
AU  - Moss AJ
AD  - University of Rochester Medical Center, Rochester, New York, USA.
FAU - Goldenberg, Ilan
AU  - Goldenberg I
AD  - University of Rochester Medical Center, Rochester, New York, USA.
FAU - Kutyifa, Valentina
AU  - Kutyifa V
AD  - University of Rochester Medical Center, Rochester, New York, USA.
FAU - Biton, Yitschak
AU  - Biton Y
AD  - University of Rochester Medical Center, Rochester, New York, USA.
FAU - McNitt, Scott
AU  - McNitt S
AD  - University of Rochester Medical Center, Rochester, New York, USA.
FAU - Zareba, Wojciech
AU  - Zareba W
AD  - University of Rochester Medical Center, Rochester, New York, USA.
FAU - Aktas, Mehmet K
AU  - Aktas MK
AD  - University of Rochester Medical Center, Rochester, New York, USA. Electronic 
      address: Mehmet_Aktas@urmc.rochester.edu.
LA  - eng
SI  - ClinicalTrials.gov/NCT00180271
PT  - Journal Article
DEP - 20160622
PL  - United States
TA  - JACC Clin Electrophysiol
JT  - JACC. Clinical electrophysiology
JID - 101656995
OTO - NOTNLM
OT  - cardiac resynchronization therapy
OT  - implantable cardioverter-defibrillators
OT  - myocardial infarction
OT  - ventricular fibrillation
OT  - ventricular tachycardia
EDAT- 2016/10/01 00:00
MHDA- 2016/10/01 00:01
CRDT- 2018/05/16 06:00
PHST- 2015/07/16 00:00 [received]
PHST- 2016/04/08 00:00 [revised]
PHST- 2016/04/14 00:00 [accepted]
PHST- 2018/05/16 06:00 [entrez]
PHST- 2016/10/01 00:00 [pubmed]
PHST- 2016/10/01 00:01 [medline]
AID - S2405-500X(16)30112-8 [pii]
AID - 10.1016/j.jacep.2016.04.010 [doi]
PST - ppublish
SO  - JACC Clin Electrophysiol. 2016 Oct;2(5):565-573. doi: 
      10.1016/j.jacep.2016.04.010. Epub 2016 Jun 22.