PMID- 29760713
OWN - NLM
STAT- MEDLINE
DCOM- 20190703
LR  - 20190703
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 9
DP  - 2018
TI  - Human Leukocyte Antigen-Class I Alleles and the Autoreactive T Cell Response in 
      Psoriasis Pathogenesis.
PG  - 954
LID - 10.3389/fimmu.2018.00954 [doi]
LID - 954
AB  - Psoriasis is a complex immune-mediated inflammatory skin disease characterized by 
      T-cell-driven epidermal hyperplasia. It occurs on a strong genetic 
      predisposition. The human leukocyte antigen (HLA)-class I allele HLA-C*06:02 on 
      psoriasis susceptibility locus 1 (PSORS1 on 6p21.3) is the main psoriasis risk 
      gene. Other HLA-class I alleles encoding HLA molecules presenting overlapping 
      peptide repertoires show associations with psoriasis as well. Outside the major 
      histocompatibility complex region, genome-wide association studies identified 
      more than 60 psoriasis-associated common gene variants exerting only modest 
      individual effects. They mainly refer to innate immune activation and the 
      interleukin-23/T(h/c)17 pathway. Given their strong risk association, explaining 
      the role of the HLA-risk alleles is essential for elucidating psoriasis 
      pathogenesis. Psoriasis lesions develop upon epidermal infiltration, activation, 
      and expansion of CD8(+) T cells. The unbiased analysis of a paradigmatic 
      Valpha3S1/Vbeta13S1-T-cell receptor from a pathogenic epidermal CD8(+) T-cell clone of 
      an HLA-C*06:02(+) psoriasis patient had revealed that HLA-C*06:02 directs an 
      autoimmune response against melanocytes through autoantigen presentation, and it 
      identified a peptide form ADAMTS-like protein 5 as an HLA-C*06:02-presented 
      melanocyte autoantigen. These data demonstrate that psoriasis is an autoimmune 
      disease, where the predisposing HLA-class I alleles promote organ-specific 
      inflammation through facilitating a T-cell response against a particular 
      skin-specific cell population. This review discusses the role of HLA-class I 
      alleles in the pathogenic psoriatic T-cell immune response. It concludes that as 
      a principle of T-cell driven HLA-associated inflammatory diseases proinflammatory 
      traits promote autoimmunity in the context of certain HLA molecules that present 
      particular autoantigens.
FAU - Prinz, Jorg Christoph
AU  - Prinz JC
AD  - Department of Dermatology, University Clinics, Ludwig-Maximilian-University of 
      Munich, Munich, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180430
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Autoantigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Alleles
MH  - Autoantigens/immunology
MH  - *Autoimmunity
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Epidermis/immunology
MH  - Genetic Predisposition to Disease
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Melanocytes/immunology
MH  - Psoriasis/*genetics/*pathology
MH  - Skin/immunology/pathology
PMC - PMC5936982
OTO - NOTNLM
OT  - HLA-C*06:02
OT  - T-cell receptor
OT  - autoantigens
OT  - autoimmunity
OT  - autoreactive T cells
OT  - human leukocyte antigen association
OT  - pathogenesis
OT  - psoriasis
EDAT- 2018/05/16 06:00
MHDA- 2018/05/16 06:01
PMCR- 2018/01/01
CRDT- 2018/05/16 06:00
PHST- 2018/02/26 00:00 [received]
PHST- 2018/04/17 00:00 [accepted]
PHST- 2018/05/16 06:00 [entrez]
PHST- 2018/05/16 06:00 [pubmed]
PHST- 2018/05/16 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2018.00954 [doi]
PST - epublish
SO  - Front Immunol. 2018 Apr 30;9:954. doi: 10.3389/fimmu.2018.00954. eCollection 
      2018.